Výsledky vyhledávání - "Robert C. Simon"

Akademický článek

Biocatalytic trifluoromethylation of unprotected phenols

Autor: Robert C. Simon, Eduardo Busto, Nina Richter, Verena Resch, Kendall N. Houk, Wolfgang Kroutil

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)

The introduction of fluorine into organic molecules often requires prefunctionalised molecules or protection of reactive functional groups. Here, the authors report a biocatalytic method for the trifluoromethylation of unprotected phenols under mild

Externí odkaz: https://doaj.org/article/9ecbf7f3240549eeaf405aee97bb10fe

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Methoxamine Synthesis in a Biocatalytic 1-Pot 2-Step Cascade Approach

Autor: Wolfgang Kroutil, Robert C. Simon, Dörte Rother, Vanessa Erdmann, Ilona Frindi-Wosch, Torsten Sehl

Publikováno v: ACS Catalysis. 9:7380-7388

Due to its function as a vasopressor, the vicinal amino alcohol methoxamine is a potential candidate for the treatment of hypotension and incontinence or has applications in ophthalmology. In this study, a biocatalytic method was developed to produce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830f9114287e7f7bb289268ca688dbc1
https://doi.org/10.1021/acscatal.9b01081

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carba Nicotinamide Adenine Dinucleotide Phosphate: Robust Cofactor for Redox Biocatalysis

Autor: Manuel Döring, Ioannis Zachos, Georg Tafertshofer, Robert C. Simon, Volker Sieber

Publikováno v: Angewandte Chemie (International Ed. in English)

Here we report a new robust nicotinamide dinucleotide phosphate cofactor analog (carba‐NADP+) and its acceptance by many enzymes in the class of oxidoreductases. Replacing one ribose oxygen with a methylene group of the natural NADP+ was found to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71020221ad336785e3027ddce46981cf
https://mediatum.ub.tum.de/doc/1616911/document.pdf

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One-Pot, Two-Module Three-Step Cascade To Transform Phenol Derivatives to Enantiomerically Pure (R)- or (S)-p-Hydroxyphenyl Lactic Acids

Autor: Robert C. Simon, Nina Richter, Wolfgang Kroutil, Eduardo Busto

Publikováno v: ACS Catalysis. 6:2393-2397

Readily available phenol derivatives were substituted in para-position via a C–C bond formation to give enantiomerically pure (R)- or (S)-3-(para-hydroxyphenyl) lactic acids. The transformation was achieved by designing a biocatalytic cascade consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::679625de2097bd046483629d309265d7
https://doi.org/10.1021/acscatal.6b00030

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Regio- and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrrolizidine Alkaloid Xenovenine Employing Transaminases

Autor: Joerg H. Schrittwieser, Stefan E. Payer, Robert C. Simon, Wolfgang Kroutil, Barbara Grischek

Publikováno v: Advanced Synthesis & Catalysis. 358:444-451

The (+)- as well as the (−)-enantiomer of the pyrrolizidine alkaloid xenovenine were prepared within five steps with 17 and 30% overall yields, respectively, in optically pure form, >99% ee as well as >99% de. In the asymmetric key step a transamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2c9b5e61618bc4a8c5adafb2a64441d
https://doi.org/10.1002/adsc.201500781

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Chiral Chlorohydrins from the Biocatalyzed Reduction of Chloroketones: Chiral Building Blocks for Antiretroviral Drugs

Autor: Leandro Marques Miranda, Rodrigo O. M. A. de Souza, Bruno A. C. Horta, Wolfgang Kroutil, Amanda S. de Miranda, Robert C. Simon, Gabriel C. de Paula, Barbara Grischek, C. Oliver Kappe

Publikováno v: ChemCatChem. 7:984-992

E. coli cells that contain overexpressed alcohol dehydrogenases (ADHs) were screened as biocatalysts for the stereoselective reduction of chloroketones 5 a–d, the corresponding halohydrins 6 a–d of which are building blocks in the synthesis of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e65867c0c8ff4b818da7ff9c0d72833
https://doi.org/10.1002/cctc.201403023

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Enzymatic and Chemoenzymatic Three-Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

Autor: Vanessa Erdmann, Jianxiong Zhao, Wolfgang Kroutil, Robert C. Simon, Dörte Rother, John M. Ward, Benjamin R. Lichman, Helen C. Hailes

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 56(41), 12503-12507 (2017). doi:10.1002/anie.201705855

Chemoenzymatic and enzymatic cascade reactions enable the synthesis of complex stereocomplementary 1,3,4‐trisubstituted tetrahydroisoquinolines (THIQs) with three chiral centers in a step‐efficient and selective manner without intermediate purifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069230ad85025859ce007e7bc266272
https://eprints.whiterose.ac.uk/139641/1/Erdmann_et_al_2017_Angewandte_Chemie_International_Edition.pdf

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