Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Robert C. Orchard"'
Autor:
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K. Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A. Mainou, Robert C. Orchard, Craig B. Wilen, Pamela H. Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S. Dermody
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3 (2022)
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficki
Externí odkaz:
https://doaj.org/article/0cec75b1fda54dfcb4fc3caf782c39b8
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryoti
Externí odkaz:
https://doaj.org/article/217bfd32a26b4c0bb9b8f8ae3db9c3fe
Autor:
Elizabeth M. Selleck, Robert C. Orchard, Kara G. Lassen, Wandy L. Beatty, Ramnik J. Xavier, Beth Levine, Herbert W. Virgin, L. David Sibley
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT A core set of autophagy proteins is required for gamma interferon (IFN-γ)-mediated clearance of Toxoplasma gondii in the mouse because of their control of several downstream effectors, including immunity-related GTPases (IRGs) and guanylate
Externí odkaz:
https://doaj.org/article/28b393fbe97e4760a7ecc6c932e146bd
Autor:
Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011351 (2023)
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including
Externí odkaz:
https://doaj.org/article/96107a75fb7e477fb76c01fbddef0ecf
Publikováno v:
Nature. 616:152-158
Autor:
Meagan E. Sullender, Linley R. Pierce, Mridula Annaswamy Srinivas, Stacey L. Crockett, Bria F. Dunlap, Rachel Rodgers, Lawrence A. Schriefer, Elizabeth A. Kennedy, Brittany M. Stewart, John G. Doench, Megan T. Baldridge, Robert C. Orchard
Publikováno v:
J Virol
Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are poorly understood. Here, we present a CRISPR activation screen that identifies mouse genes which
Autor:
Madison S. Strine, Mia Madel Alfajaro, Vincent R. Graziano, Jaewon Song, Leon L. Hsieh, Ryan Hill, Jun Guo, Kelli L. VanDussen, Robert C. Orchard, Megan T. Baldridge, Sanghyun Lee, Craig B. Wilen
Publikováno v:
Cell reports. 41(6)
Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV
Autor:
Dale R. Balce, Megan T. Baldridge, Herbert W. Virgin, Qun Lu, Chandni Desai, Konstantin Zaitsev, Lindsay Droit, Craig B. Wilen, Sunmin Park, Darren Kreamalmeyer, Shan Li, Maxim N. Artyomov, Ki-Wook Kim, Christina L. Stallings, Anthony Orvedahl, John D. Pfeifer, Ya-Ting Wang, Scott A. Handley, Robert C. Orchard, W. Timothy Schaiff
Publikováno v:
Nature microbiology
Innate and adaptive immune responses that prime myeloid cells, such as macrophages, protect against pathogens1,2. However, if left uncontrolled, these responses may lead to detrimental inflammation3. Macrophages, particularly those resident in tissue
Autor:
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K. Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A. Mainou, Robert C. Orchard, Craig B. Wilen, Pamela H. Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S. Dermody
Publikováno v:
PLoS pathogens. 18(3)
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficki
Autor:
Jin Wei, Vincent R. Graziano, Renata B. Filler, Sanghyun Lee, Craig B. Wilen, Mia Madel Alfajaro, Madison S. Strine, Timothy J. Nice, Cameron O. Schmitz, Megan T. Baldridge, Robert C. Orchard, Leon L. Hsieh
Publikováno v:
J Virol
Noroviruses are a leading cause of gastrointestinal infection in humans and mice. Understanding human norovirus (HuNoV) cell tropism has important implications for our understanding of viral pathogenesis. Murine norovirus (MNoV) is extensively used a