Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert C. Moen"'
Autor:
Leroy Muya, Mark E. Cooper, Thomas A. Ciulla, Viral Kansara, Ozge Sesenoglu-Laird, Robert C. Moen
Publikováno v:
Translational Vision Science & Technology
Purpose This study evaluated ocular tolerability and transfectability of nonviral DNA nanoparticles (DNPs) after microneedle-based suprachoroidal (SC) administration, in comparison to subretinal (SR) administration. Methods The DNPs consisted of a si
Autor:
Tomasz Kowalczyk, Linas Padegimas, Olena Tyr, Susannah L. Hyatt, Ozge Sesenoglu-Laird, Chris R Gedeon, Sam Adams, Karla Dines, Robert C. Moen, Mark J. Cooper, Sharon M. Oette
Publikováno v:
Molecular Therapy. 20(1):63-72
Efficient and prolonged human cystic fibrosis transmembrane conductance regulator (hCFTR) expression is a major goal for cystic fibrosis (CF) lung therapy. A hCFTR expression plasmid was optimized as a payload for compacted DNA nanoparticles formulat
Autor:
Robert C. Moen, Christopher R. Gedeon, Osman Muhammad, Jennifer M. Payne, Pamela B. Davis, Assem G. Ziady, Will Quan, Angela Peischl, Tamara L. Fink, Virginia Stillwell, Susannah L. Hyatt, Sharon M. Oette, Tomasz H. Kowalczyk, J. E. Seng, Mark J. Cooper
Publikováno v:
Molecular Therapy. 8:948-956
Nanoparticles containing DNA compacted with poly-l-lysine modified on an N-terminal cysteine with polyethylene glycol can effectively transfect cells of the airway epithelium when applied by the luminal route. To evaluate the toxicity of these nanopa
Autor:
Jennifer M. Payne, Pamela B. Davis, Susannah L. Hyatt, Murali K. Pasumarthy, Assem-Galal Ziady, Sharon M. Oette, Mark J. Cooper, Tomasz Kowalczyk, Tamara L. Fink, Osman Muhammad, Robert C. Moen, Christopher R. Gedeon, William Quan, Timothy J. Miller
Publikováno v:
Molecular Therapy. 8(6):936-947
DNA can be compacted using polyethylene glycol-substituted poly-L-lysine into discrete unimolecular (with respect to DNA) nanoparticles with minor diameter < 20 nm that are stable in normal saline for at least 23 months at 4 degrees C. We compared th
Autor:
Donald B. Kohn, Kenneth I. Weinberg, Jan A. Nolta, Linda N. Heiss, Carl Lenarsky, Gay M. Crooks, Mary E. Hanley, Geralyn Annett, Judith S. Brooks, Anthony El-Khoureiy, Kim Lawrence, Susie Wells, Robert C. Moen, John Bastian, Debora E. Williams-Herman, Melissa Elder, Diane Wara, Thomas Bowen, Michael S. Hershfield, Craig A. Mullen, R. Michael Blaese, Robertson Parkman
Publikováno v:
Nature Medicine. 1:1017-1023
Haematopoietic stem cells in umbilical cord blood are an attractive target for gene therapy of inborn errors of metabolism. Three neonates with severe combined immunodeficiency were treated by retroviral-mediated transduction of the CD34+ cells from
Autor:
Berenson R, F. M. Stewart, Joyce A. O'Shaughnessy, J.J. Greenblatt, Robert C. Moen, Corey A. Carter, Sandra Doren, Michele Cottler-Fox, S Brown, Cynthia E. Dunbar
Publikováno v:
Blood. 85:3048-3057
We report here on a preliminary human autologous transplantation study of retroviral gene transfer to bone marrow (BM) and peripheral blood (PB)-derived CD34-enriched cells. Eleven patients with multiple myeloma or breast cancer had cyclophosphamide
Autor:
Victor M. Santana, James N. Ihle, Malcolm K. Brenner, Robert A. Krance, W. Mark Roberts, Laura C. Bowman, Terri Nilson, Helen E. Heslop, Robert C. Moen, Donna Rill
Publikováno v:
Blood. 84:380-383
Patients with solid tumors are increasingly being treated by autologous bone marrow transplantation (BMT). Although response rates appear to be increased, disease recurrence is the commonest cause of treatment failure. Whether relapse is entirely due
Autor:
Debra Ellerson, Karen Janicek, Z. Zu, Joy Hamer, Patricia Tibbits, David F. Claxton, Martin Korbling, April G. Durett, Siqing Fu, Moshe Talpaz, Ronald J. Berenson, Hagop M. Kantarjian, Leslie Calvert, Jeane P. Hester, Shelly Heimfeld, Albert B. Deisseroth, Robert C. Moen, Michael Thomas, Christopher L. Reading, E. G. Hanania, Leah Goldberg, Richard E. Champlin, W. French Anderson
Publikováno v:
Blood. 83:3068-3076
Relapse after autologous bone marrow transplantation for chronic myelogenous leukemia (CML) can be due either to the persistence of leukemia cells in systemic tissues following preparative therapy, or due to the persistence of leukemia cells in the a
Autor:
Robert A. Krance, Malcolm K. Brenner, Helen E. Heslop, Donna Rill, Joseph Mirro, W. French Anderson, James N. Ihle, Robert C. Moen
Publikováno v:
Annals of the New York Academy of Sciences. 716:204-215
If residual cancer cells in harvested bone marrow could be marked and subsequently detected in patients at relapse, valuable information would be obtained about the source of recurrent disease after autologous marrow transplantation. If normal progen