Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert C. Kelly"'
Autor:
Gage James R, Kristina S. Fors, Robert C. Kelly, Richard F. Heier, Perrault William R, Wicnienski Nancy Anne
Publikováno v:
The Journal of Organic Chemistry. 63:7348-7356
PNU-140690, an inhibitor of the HIV protease enzyme undergoing clinical evalution as a chemotherapeutic agent for treatment of AIDS, was synthesized by a convergent approach amenable to large-scale preparation in a pilot plant environment. The key st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57d9e75a9a2daadc399bdc64e530078
https://doi.org/10.1021/jo9809229
https://doi.org/10.1021/jo9809229
Autor:
Robert C. Kelly, Daekyu Sun, Frederick C. Seaman, Seung Joo Lee, Heping Xiong, Laurence H. Hurley
Publikováno v:
Journal of the American Chemical Society. 119:3434-3442
In this contribution we demonstrate that Bizelesin can translocate along the minor groove of DNA from a kinetically favored monoalkylation site to a thermodynamically favored cross-linking site. This translocation is prevented in compounds that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0a8f00aad1ffc35d2994c30e28fde50
https://doi.org/10.1021/ja963873v
https://doi.org/10.1021/ja963873v
Publikováno v:
ChemInform. 28
The monoalkylation and cross-linking reactivities of a group of four structurally related DNA−DNA interstrand cross-linkers have been determined on restriction enzyme fragments and select oligomers. These highly potent cytotoxic DNA−DNA cross-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91b2e49274db6ce372c828b8ab64b577
https://doi.org/10.1002/chin.199706195
https://doi.org/10.1002/chin.199706195
Autor:
Robert C. Kelly, Wicnienski Nancy Anne, Kristina S. Fors, Gage James R, Richard F. Heier, Perrault William R
Publikováno v:
ChemInform. 30
PNU-140690, an inhibitor of the HIV protease enzyme undergoing clinical evalution as a chemotherapeutic agent for treatment of AIDS, was synthesized by a convergent approach amenable to large-scale preparation in a pilot plant environment. The key st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d034ea8f31c01c2fc941cfbd7a0e66da
https://doi.org/10.1002/chin.199913165
https://doi.org/10.1002/chin.199913165
Autor:
Wenyun Lu, Bonnie L. Bassler, Joshua D. Rabinowitz, Douglas A. Higgins, Frederick M. Hughson, Wai Leung Ng, Robert C. Kelly, Megan E. Bolitho, Philip D. Jeffrey, Martin F. Semmelhack
Publikováno v:
Nature chemical biology
Vibrio cholerae, the bacterium that causes the disease cholera, controls virulence factor production and biofilm development in response to two extracellular quorum-sensing molecules, called autoinducers. The strongest autoinducer, called CAI-1 (for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f0bbb40c7bb02c410d4d8868a5d27e
https://pubmed.ncbi.nlm.nih.gov/19915530
https://pubmed.ncbi.nlm.nih.gov/19915530
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(3)
Paclitaxel and docetaxel can induce pro-inflammatory proteins, typified by cyclooxygenase-2 (prostaglandin H synthase). In some circumstances, this phenomenon may be relevant to the immunomodulatory actions and the adverse effects associated with pac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e05915005f897977a259c34ec317b181
https://pubmed.ncbi.nlm.nih.gov/11895918
https://pubmed.ncbi.nlm.nih.gov/11895918
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 88(19)
Dynemicin A is a recently identified antitumor antibiotic. Upon activation, dynemicin is reported to cause double-stranded cleavage of DNA, putatively through the intermediacy of a diradical. Computer modeling of this activation and cleavage process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec78d0a906f50344629cb745626822f
https://pubmed.ncbi.nlm.nih.gov/1924343
https://pubmed.ncbi.nlm.nih.gov/1924343
Autor:
Arthur Toy, Roy A. Johnson, Constance G. Chidester, Stephen A. Mizsak, Paul J. Dobrowolski, Thomas A. Runge, Robert C. Kelly, Wicnienski Nancy Anne, Samuel J. Qualls, Eldon G. Nidy
Publikováno v:
The Journal of Organic Chemistry. 62:4900-4901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ff5e561260cde66a0138e0a177db59
https://doi.org/10.1021/jo970645q
https://doi.org/10.1021/jo970645q
Autor:
Robert C. Kelly, Wicnienski Nancy Anne, David R. Siemieniak, Jerry L. Slightom, Gary L. Petzold, Nicole T. Hatzenbuhler, Mark A. Mitchell, Marta G. Williams
Publikováno v:
Journal of the American Chemical Society. 113:8994-8995
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47ff8f0efa16e7f184eb327d330deba
https://doi.org/10.1021/ja00023a085
https://doi.org/10.1021/ja00023a085
Autor:
David G. Martin, Robert C. Kelly, Stephen A. Mizsak, William Watt, Wicnienski Nancy Anne, James W. Nielsen, Mark D. Prairie
Publikováno v:
The Journal of Organic Chemistry. 53:4610-4613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb95e3fe46c9b995edf57bfed3b6549
https://doi.org/10.1021/jo00254a046
https://doi.org/10.1021/jo00254a046