Výsledky vyhledávání - "Robert C. Holley"

Methamphetamine exposure antagonizes N-methyl-d-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures

Autor: Robert C. Holley, Katherine J. Smith, John M. Littleton, Tracy Butler, Layla Ghayoumi, Mark A. Prendergast, Michael M. Mullins, Rachel L. Self

Publikováno v: Brain Research. 1157:74-80

Glutamatergic systems have been increasingly recognized as mediators of methamphetamine's (METH) pharmacological effects though little is known about the means by which METH interacts with glutamate receptors. The present studies examined effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0668924bbbb09d8ae499a7f9af3f9207
https://doi.org/10.1016/j.brainres.2007.04.056

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Potential Value of Changes in Cell Markers in Organotypic Hippocampal Cultures Associated With Chronic EtOH Exposure and Withdrawal: Comparison with NMDA-Induced Changes

Autor: John A. Blanchard, Lincoln H. Wilkins, John M. Littleton, Robert C. Holley, Elton R. Chambers, Mark A. Prendergast

Publikováno v: Alcoholism: Clinical and Experimental Research. 30:1768-1780

Background: Previous studies have shown that withdrawal from ethanol (EtOH) exposure induces neuronal damage, as indicated by propidium iodide (PI) uptake, in organotypic hippocampal slice cultures. This is prevented by MK801, suggesting that damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8691cc361b92dfcc9a913277fe7ba95
https://doi.org/10.1111/j.1530-0277.2006.00210.x

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The Neurotoxicity Induced by Ethanol Withdrawal in Mature Organotypic Hippocampal Slices Might Involve Cross-Talk Between Metabotropic Glutamate Type 5 Receptors and N-Methyl-d-Aspartate Receptors

Autor: Stewart R. Hart, Thomas C. Foster, Robert C. Holley, Rebecca L. Scotland, John A. Blanchard, Barton R. Harris, Norman W. Pedigo, John M. Littleton, D. Alex Gibson, Mark A. Prendergast

Publikováno v: Alcoholism: Clinical & Experimental Research. 27:1724-1735

Background: We recently reported that the sodium salt of acamprosate (Na-acamprosate) demonstrates the characteristics of an antagonist at metabotropic glutamate type 5 receptors (mGluR5s) rather than at N-methyl-d-aspartate receptors (NMDARs). Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafd0a70fd5b23b0a67a0a9b78292724
https://doi.org/10.1097/01.alc.0000093601.33119.e3

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Polyamines Contribute to Ethanol Withdrawal-Induced Neurotoxicity in Rat Hippocampal Slice Cultures Through Interactions With the NMDA Receptor

Autor: Barton R. Harris, Norman W. Pedigo, John M. Littleton, A I I John Blanchard, D. Alex Gibson, Mark A. Prendergast, Robert C. Holley, Stewart R. Hart

Publikováno v: Alcoholism: Clinical & Experimental Research. 27:1099-1106

BACKGROUND: Several reports demonstrate that withdrawal from long-term ethanol exposure is associated with significant central nervous system neurotoxicity, produced at least in part by increased activity of N-methyl-d-aspartate receptors (NMDARs). R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72881ce8b90e0a5accf68110b5530b98
https://doi.org/10.1097/01.alc.0000075824.10502.dd

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Acamprosate Has No Effect on NMDA-Induced Toxicity But Reduces Toxicity Induced by Spermidine or by Changing the Medium in Organotypic Hippocampal Slice Cultures From Rat

Autor: Sveta Mayer, Robert C. Holley, John A. Blanchard, D. Alex Gibson, Mark A. Prendergast, John M. Littleton, Barton R. Harris

Publikováno v: Alcoholism: Clinical and Experimental Research. 26:655-662

BACKGROUND: It has been suggested that the antirelapse drug acamprosate can inhibit or potentiate glutamate/NMDA receptor-mediated responses via a polyamine site. Additionally, subchronic exposure to acamprosate increases expression of some NMDA rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45312183ce3f1dcd9870f02df5141464
https://doi.org/10.1111/j.1530-0277.2002.tb02587.x

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Chronic nicotine exposure reduces N-methyl-d-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression

Autor: Barton R. Harris, Sveta Mayer, Robert C. Holley, Kurt F. Hauser, John M. Littleton, Mark A. Prendergast

Publikováno v: Neuroscience. 102:75-85

Neuronal accumulation of excess Ca2+ has been implicated in cellular death following several forms of physical and chemotoxic insult. Recent studies have suggested that exposure to agonists at brain nicotinic acetylcholine receptors reduces cytotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b4493203aac0eb2d1ce279fc5da03
https://doi.org/10.1016/s0306-4522(00)00450-4

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Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence

Autor: Kristen Wellmann, Dennis T. Rogers, Josh Ring, John M. Littleton, Peter A. Crooks, Megan Carter, Robert C. Holley, Ben Lewis, Justin M. Farook, Susan Barron

Publikováno v: Scopus-Elsevier

Relapse and neurodegeneration are two of the major therapeutic targets in alcoholism. Fortuitously, the roles of glutamate/NMDA receptors (NMDARs) in withdrawal, conditioning and neurotoxicity mean that NMDAR inhibitors are potentially valuable for b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c0fea03ecb2066b0da30e00b91dc28
https://pubmed.ncbi.nlm.nih.gov/22574674

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Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression

Autor: Patrick J. Mulholland, Rachel L. Self, Lincoln H. Wilkins, John M. Littleton, Mark A. Prendergast, Robert C. Holley, Barton R. Harris, John A. Blanchard

Publikováno v: Alcohol (Fayetteville, N.Y.). 31(1-2)

Long-term ethanol exposure produces multiple neuroadaptations that likely contribute to dysregulation of Ca2+ balance and neurotoxicity during ethanol withdrawal. Conversely, nicotine exposure may reduce the neurotoxic consequences of Ca2+ dysregulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca049d78492c8ee1dbfce1aca7cbacf
https://pubmed.ncbi.nlm.nih.gov/14615005

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Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors

Autor: Barton R, Harris, Mark A, Prendergast, D Alex, Gibson, D Trent, Rogers, John A, Blanchard, Robert C, Holley, May C, Fu, Stewart R, Hart, Norman W, Pedigo, John M, Littleton

Publikováno v: Alcoholism, clinical and experimental research. 26(12)

Several reported effects of acamprosate within the glutamatergic system could result from interactions with metabotropic glutamate receptors (mGluRs). The following experiments were performed to determine whether acamprosate could compete with trnas-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b178bfc5bba18ef69447e83fc23169c
https://pubmed.ncbi.nlm.nih.gov/12500101

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