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pro vyhledávání: '"Robert C. Dutcher"'
Autor:
Karina Jouravleva, Dmitrij Golovenko, Gabriel Demo, Robert C. Dutcher, Traci M. Tanaka Hall, Phillip D. Zamore, Andrei A. Korostelev
Publikováno v:
Molecular Cell. 82:4049-4063.e6
SUMMARYIn animals and plants, Dicer enzymes collaborate with double-stranded RNA-binding proteins to convert precursor-microRNAs (pre-miRNAs) into miRNA duplexes. We report six cryo-EM structures of Drosophila Dicer-1 and its partner Loqs-PB. The str
Autor:
Marvin Wickens, Yoav Arava, Chen Qiu, Robert C Dutcher, Traci M. Tanaka Hall, Douglas F. Porter
Publikováno v:
Nucleic Acids Research.
PUF proteins, named for Drosophila Pumilio (PUM) and Caenorhabditis elegans fem-3-binding factor (FBF), recognize specific sequences in the mRNAs they bind and control. RNA binding by classical PUF proteins is mediated by a characteristic PUM homolog
Autor:
Ryuya Fukunaga, Phillip D. Zamore, Traci M. Tanaka Hall, Yeming Wang, Elif Sarinay Cenik, Gang Lu, Robert C Dutcher
Publikováno v:
Molecular Cell. 42(2):172-184
Summary Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for their biological substrates? We find that p