Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robert C. De Lisle"'
Autor:
Robert C. De Lisle, Andrew Ballabio, Thomas R. Kolodecik, Hong-Min Ni, Pal Pacher, Shaogui Wang, Xiaowen Ma, Wen-Xing Ding, Xiaojuan Chao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 59-81 (2020)
Background & Aims Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec45512565c8efd0aab9e794fd44a27
http://www.sciencedirect.com/science/article/pii/S2352345X2030014X
http://www.sciencedirect.com/science/article/pii/S2352345X2030014X
Autor:
Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72543 (2013)
BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods/pri
Externí odkaz:
https://doaj.org/article/83a06b4ef9494a5aab94221ac8aff609
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82149 (2013)
ZIP5 localizes to the baso-lateral membranes of intestinal enterocytes and pancreatic acinar cells and is internalized and degraded coordinately in these cell-types during periods of dietary zinc deficiency. These cell-types are thought to control zi
Externí odkaz:
https://doaj.org/article/7c89b091af7d4f3e934652a5bc218e4b
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002766 (2012)
Mutations in the human Zip4 gene cause acrodermatitis enteropathica, a rare, pseudo-dominant, lethal genetic disorder. We created a tamoxifen-inducible, enterocyte-specific knockout of this gene in mice which mimics this human disorder. We found that
Externí odkaz:
https://doaj.org/article/6114b6f5a14b40c5a81eabaeb4b40098
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4283 (2009)
BACKGROUND: Cystic fibrosis (CF) has many effects on the gastrointestinal tract and a common problem in this disease is poor nutrition. In the CF mouse there is an innate immune response with a large influx of mast cells into the muscularis externa o
Externí odkaz:
https://doaj.org/article/37b1af70df8547ef8ab72db5ce73c0e1
Autor:
Pal Pacher, Hua Wang, Anna S. Gukovskaya, Sean C. Kumer, Robert C. De Lisle, Shaogui Wang, Olga A. Mareninova, Brian Bridges, Hong-Min Ni, Andrea Ballabio, Xiaojuan Chao, Wen-Xing Ding, Timothy M. Schmitt
Publikováno v:
Autophagy. 15(11)
Impaired macroautophagy/autophagy has been implicated in experimental and human pancreatitis. However, the transcriptional control governing the autophagy-lysosomal process in pancreatitis is largely unknown. We investigated the role and mechanisms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667cf7b6e87022eb5c0e2eb54c4c6a6b
https://pubmed.ncbi.nlm.nih.gov/30894069
https://pubmed.ncbi.nlm.nih.gov/30894069
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 55:689-694
Intestinal dysmotility is one of the effects of cystic fibrosis (CF), but when and how this develops is not well understood. The goal of the present study was to use the Cftr knockout mouse to determine when in development circular smooth muscle of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f59eac23f60482f3baa64a125785ef
https://doi.org/10.1097/mpg.0b013e3182638bf4
https://doi.org/10.1097/mpg.0b013e3182638bf4
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G717-G727
The Dmbt1 gene encodes alternatively spliced glycoproteins that are either membrane-associated or secreted epithelial products. Functions proposed for Dmbt1 include it being a tumor suppressor, having roles in innate immune defense and inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38758157e614dfe0297ae9df9b33d1a
https://doi.org/10.1152/ajpgi.00525.2007
https://doi.org/10.1152/ajpgi.00525.2007
Publikováno v:
Molecular and Cellular Biochemistry. 302:157-167
The C-terminal PDZ-binding motifs are required for polarized apical/basolateral localization of many membrane proteins. Ezrin-radixin-moesin (ERM) proteins regulate the organization and function of specific cortical structures in polarized epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc79cee051531998fdede56789266a4
https://doi.org/10.1007/s11010-007-9437-2
https://doi.org/10.1007/s11010-007-9437-2
Autor:
Robert C. De Lisle
Publikováno v:
Journal of pediatric gastroenterology and nutrition. 62(4)
OBJECTIVES Cystic fibrosis (CF) has major effects on the intestinal tract with potential consequences on nutrition, but these are not fully understood. I investigated the possibility of altered enterocyte maturation in CF, as suggested by decreased e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44027b63aeeacec66ebc7618ea895e2f
https://pubmed.ncbi.nlm.nih.gov/26594833
https://pubmed.ncbi.nlm.nih.gov/26594833