Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Robert C. Cumming"'
Autor:
Ariel K. Frame, Jessica L. Sinka, Marc Courchesne, Rashad A. Muhammad, Sandra Grahovac-Nemeth, Mark A. Bernards, Robert Bartha, Robert C. Cumming
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110342- (2024)
Summary: The astrocyte-neuron lactate shuttle (ANLS) model posits that astrocyte-generated lactate is transported to neurons to fuel memory processes. However, neurons express high levels of lactate dehydrogenase A (LDHA), the rate-limiting enzyme of
Externí odkaz:
https://doaj.org/article/3ed75eb25af84bd4acc33d15401d1d63
Autor:
Ryley T. Yost, J. Wesley Robinson, Carling M. Baxter, Andrew M. Scott, Liam P. Brown, M. Sol Aletta, Ramtin Hakimjavadi, Asad Lone, Robert C. Cumming, Reuven Dukas, Brian Mozer, Anne F. Simon
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4601 (2020)
Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and agg
Externí odkaz:
https://doaj.org/article/277d198293054c3fa08e6f0316aec50a
Autor:
Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated lactate is transported to neurons to fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed that lactate shuttling is important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16118bebcaffe599c7b5d11c59eade28
https://doi.org/10.1101/2022.10.19.512981
https://doi.org/10.1101/2022.10.19.512981
Autor:
Ariel K. Frame, Robert C. Cumming
Publikováno v:
Cell metabolism. 34(8)
Astrocytes are brain cells that react to Alzheimer's disease pathology in ways that can have either beneficial or detrimental effects. In this issue of Cell Metabolism, Ju et al. outline a novel strategy for coercing astrocytes to a neuroprotective s
Autor:
David A. Hendrix, Robert C. Cumming, Patrick N. Reardon, Dani M Long, Ariel K. Frame, Jadwiga M. Giebultowicz, Doris Kretzschmar
Publikováno v:
Aging (Albany NY)
Paediatrics Publications
Paediatrics Publications
Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease p
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Paediatrics Publications
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Recent evidence has emerged that cancer cells can use various metabolites as fuel sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote metabolic changes leading to enhanced glycolysis or mitochondrial OXPHOS. However
Publikováno v:
Journal of Epidemiology and Community Health
Journal of Epidemiology and Community Health, 2020, pp.jech-2020-214297. ⟨10.1136/jech-2020-214297⟩
Journal of Epidemiology and Community Health, 2020, pp.jech-2020-214297. ⟨10.1136/jech-2020-214297⟩
International audience; Disadvantaged socioeconomic position (SEP) is widely associated with disease and mortality, and there is no reason to think this will not be the case for the newly emerged coronavirus disease 2019 (COVID-19) that has reached a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50932748d1974f95ca81c9bbbb1fb2c7
https://hal.science/hal-03608638/document
https://hal.science/hal-03608638/document
Autor:
Jordan T Newington, Andrea Pitts, Andrew Chien, Robert Arseneault, David Schubert, Robert C Cumming
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19191 (2011)
Amyloid beta (Aβ) peptide accumulation in the brains of patients with Alzheimer's disease (AD) is closely associated with increased nerve cell death. However, many cells survive and it is important to understand the mechanisms involved in this survi
Externí odkaz:
https://doaj.org/article/65ba085fc0ea441281202ff85aa0d6b0
Publikováno v:
Bio Protoc
The Morris water maze (MWM) is one of the most commonly used tests for assessing spatial learning and memory in mice. While the MWM is highly amenable to testing the effects of memory modifying drugs, most studies do not consider the timing or durati