Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert C. Bunn"'
Autor:
Sarah McDonald, Phil Ray, Robert C. Bunn, John L. Fowlkes, Kathryn M. Thrailkill, Iuliana Popescu
Publikováno v:
Acta histochemica. 124(7)
A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2 diabetes (T2D). New evidence suggests that in T2D, β-cells are not destroyed but experience a l
Autor:
Corey B. Hughes, George M. Mussman, Kathryn M. Thrailkill, Phil Ray, Virgilius Cornea, Robert C. Bunn, Iuliana Popescu, John L. Fowlkes
Publikováno v:
Cell and Tissue Research. 384:527-543
Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect exerted by the inhibition of glucose reabsorption in the kidney. Inhibition of SGLT2 is ass
Publikováno v:
Journal of the Endocrine Society
Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2is) are a class of anti-hyperglycemic drugs that lower blood glucose in an insulin-independent manner by inhibiting renal glucose reabsorption and promoting glucosuria. In persons w
Autor:
David L. Becton, Jaclyn VanderSchilden, Richard W. Nicholas, Kimo C. Stine, Lichu Liu, Robert C. Bunn, Charles K. Lumpkin, Larry J. Suva, Corey O. Montgomery, Robert A. Skinner, James Aronson, Elizabeth C. Wahl, Christopher J. Swearingen
Publikováno v:
Journal of Orthopaedic Research. 34:1716-1724
The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols include distraction osteogenesis (DO), which is characterized by direct new bone formation. Cisplatin (C
Autor:
David L. Becton, Lichu Liu, Larry J. Suva, James Aronson, Robert A. Skinner, Robert C. Bunn, Corey O. Montgomery, Christopher J. Swearingen, Kimo C. Stine, Elizabeth C. Wahl, Charles K. Lumpkin, Jacquelyn VanderSchilden, Richard W. Nicholas
Publikováno v:
Journal of Orthopaedic Research. 32:464-470
Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. Surgical reconstructions after tumor resection include
Autor:
Robert C. Bunn, Charles K. Lumpkin, Lichu Liu, Robert A. Skinner, James Aronson, Elizabeth C. Wahl, Gael Cockrell, Kathryn M. Thrailkill, John L. Fowlkes, Mike J. Miller, Martin J. J. Ronis
Publikováno v:
Bone. 46:410-417
Distraction osteogenesis (DO) is a process which induces direct new bone formation as a result of mechanical distraction. Tumor necrosis factor-alpha (TNF) is a cytokine that can modulate osteoblastogenesis. The direct effects of TNF on direct bone f
Autor:
Chan-Hee Jo, Kathryn M. Thrailkill, Robert C. Bunn, Cynthia S. Moreau, John L. Fowlkes, Alba E. Morales-Pozzo, Charles K. Lumpkin, Gael Cockrell
Publikováno v:
Endocrine. 37:336-343
Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal injury, can bind matrix metalloproteinase-9 (MMP-9) and inhibit its degradation, thereby sustaining MMP-9 proteolytic activity. MMP-9 is produced by renal podocytes, and podocyte
Autor:
Charles K. Lumpkin, Mallikarjuna Rettiganti, Jeffry S. Nyman, John L. Fowlkes, Elizabeth C. Wahl, Gael Cockrell, Kathryn M. Thrailkill, Sasidhar Uppuganti, Robert C. Bunn
Publikováno v:
Bone. 105:316
Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone, thought to be mediated, in part, by the consequences of chronic hyperglycemia. Therefore, to examine
Autor:
James Aronson, Thomas M. Badger, Lichu Liu, Charles K. Lumpkin, Mike J. Miller, Kathryn M. Thrailkill, Gael Cockrell, John L. Fowlkes, Robert C. Bunn, Carlos M. Isales, Robert A. Skinner, Elizabeth C. Wahl, Lindsey M. Clark, Yang Ou, Martin J. J. Ronis, John E. Sims
Publikováno v:
Journal of Bone and Mineral Research
Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised bone regeneration potential. These changes are associated with increased serum levels of sel
Autor:
Stephen F. Kemp, Hannah N. Coleman, J. Paul Frindik, John L. Fowlkes, Gael Cockrell, Pippa Simpson, Cynthia S. Moreau, Kathryn M. Thrailkill, Robert C. Bunn
Publikováno v:
Diabetes Care. 30:2321-2326
OBJECTIVE—Dysregulation of matrix metalloproteinase (MMP)-2 may contribute pathologically to the development of diabetes complications, including diabetic retinopathy and coronary and peripheral arterial disease. Our objective was to explore whethe