Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Robert C. A. M. van Waardenburg"'
Autor:
Evan J. Brettrager, Selma M. Cuya, Zachary E. Tibbs, Jun Zhang, Charles N. Falany, Stephen G. Aller, Robert C. A. M. van Waardenburg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent reaction intermediate that is the target of the camptothecin class of chemotherapeut
Externí odkaz:
https://doaj.org/article/8d1bf68e18c94921a249cac7993ebd2a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Sulfotransferase 4A1 (SULT4A1) is an orphan member of the cytosolic SULT superfamily that contains enzymes that catalyze the sulfonation of hydrophobic drugs and hormones. SULT4A1 has been assessed through all classical SULT approaches yet n
Externí odkaz:
https://doaj.org/article/5603704e182f49299dc74dfff74d5258
Autor:
Patrick L. Garcia, Aubrey L. Miller, Ling Zeng, Robert C. A. M. van Waardenburg, Eddy S. Yang, Karina J. Yoon
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage. Based on these findings, we hypothesized that a BETi would augment DN
Externí odkaz:
https://doaj.org/article/12e8ae439ad14ecdb98cf3110f05bea0
Autor:
Aubrey L. Miller, Patrick L. Garcia, Samuel C. Fehling, Tracy L. Gamblin, Rebecca B. Vance, Leona N. Council, Dongquan Chen, Eddy S. Yang, Robert C. A. M. van Waardenburg, Karina J. Yoon
Publikováno v:
Cancers, Vol 13, Iss 3470, p 3470 (2021)
Cancers
Volume 13
Issue 14
Cancers
Volume 13
Issue 14
Gemcitabine is used to treat pancreatic cancer (PC), but is not curative. We sought to determine whether gemcitabine + a BET bromodomain inhibitor was superior to gemcitabine, and identify proteins that may contribute to the efficacy of this combinat
Publikováno v:
Encyclopedia of Signaling Molecules ISBN: 9781461464389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ed78e67f56c41391eea79b3cda4ede
https://doi.org/10.1007/978-1-4614-6438-9_101921-1
https://doi.org/10.1007/978-1-4614-6438-9_101921-1
Autor:
Robert C A M, van Waardenburg, Laurina A, de Jong, Foke, van Delft, Maria A J, van Eijndhoven, Melanie, Bohlander, Mary-Ann, Bjornsti, Jaap, Brouwer, Jan H M, Schellens
Publikováno v:
Molecular cancer therapeutics. 3(4)
Phase I and II clinical trails are currently investigating the antitumor activity of cisplatin and camptothecins (CPTs; DNA topoisomerase I poisons), based on the dramatic synergistic cytotoxicity of these agents in some preclinical models. However,