Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Robert C Tuckey"'
Autor:
Shelley Gorman, Naomi M Scott, Daryl H W Tan, Clare E Weeden, Robert C Tuckey, Jacqueline L Bisley, Michele A Grimbaldeston, Prue H Hart
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46006 (2012)
Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance b
Externí odkaz:
https://doaj.org/article/eb8f32f9884f4dccb314bc6c7866870b
Autor:
Andrzej T Slominski, Zorica Janjetovic, Brian E Fuller, Michal A Zmijewski, Robert C Tuckey, Minh N Nguyen, Trevor Sweatman, Wei Li, Jordan Zjawiony, Duane Miller, Tai C Chen, Gerard Lozanski, Michael F Holick
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9907 (2010)
Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)(2)D3, as well as 1-hydroxyvitamin D3 to 1alpha,20-dihydroxyvitamin D3 (1,20(OH)(2)D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehyd
Externí odkaz:
https://doaj.org/article/e25ec502e54c4c9e8fe2d41f1ea5b55a
Autor:
Zorica Janjetovic, Michal A Zmijewski, Robert C Tuckey, Damon A DeLeon, Minh N Nguyen, Lawrence M Pfeffer, Andrzej T Slominski
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5988 (2009)
The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes. Since
Externí odkaz:
https://doaj.org/article/0c9c17732bd242c79824e083def92134
Autor:
Andrzej T Slominski, Michal A Zmijewski, Igor Semak, Trevor Sweatman, Zorica Janjetovic, Wei Li, Jordan K Zjawiony, Robert C Tuckey
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4309 (2009)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats,
Externí odkaz:
https://doaj.org/article/ac2c35ed227a4faeb4b047a77b77d0ac
Autor:
Zorica Janjetovic, Shariq Qayyum, Sivani B. Reddy, Ewa Podgorska, S. Gates Scott, Justyna Szpotan, Alisa A. Mobley, Wei Li, Vijay K. Boda, Senthilkumar Ravichandran, Robert C. Tuckey, Anton M. Jetten, Andrzej T. Slominski
Publikováno v:
Cells, Vol 13, Iss 3, p 239 (2024)
We investigated multiple signaling pathways activated by CYP11A1-derived vitamin D3 hydroxymetabolites in human skin fibroblasts by assessing the actions of these molecules on their cognate receptors and by investigating the role of CYP27B1 in their
Externí odkaz:
https://doaj.org/article/49e273a96d6b44959945a696dfc09806
Autor:
Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Stuart G. Jarrett, John A. D'Orazio, Michael F. Holick, Edith K.Y. Tang, Robert C. Tuckey, Uraiwan Panich, Wei Li, Andrzej T. Slominski
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
We tested whether novel CYP11A1-derived vitamin D3- and lumisterol-hydroxyderivatives, including 1,25(OH)2D3, 20(OH)D3, 1,20(OH)2D3, 20,23(OH)2D3, 1,20,23(OH)3D3, lumisterol, 20(OH)L3, 22(OH)L3, 20,22(OH)2L3, and 24(OH)L3, can protect against UVB-ind
Externí odkaz:
https://doaj.org/article/f0a5b634dfe44aa4bdf6e2e7a315bd20
Autor:
Imtaiyaz Hassan, Radomir M. Slominski, Andrzej Slominski, Shariq Qayyum, Taj Mohammad, Robert C. Tuckey, Chander Raman
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
Vitamin D deficiency significantly correlates with the severity of SARS-CoV-2 infection. Molecular docking-based virtual screening studies predict that novel vitamin D and related lumisterol hydroxymetabolites are able to bind to the active sites of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98403008c3acb1995416d06f515340e0
http://europepmc.org/articles/PMC8328521
http://europepmc.org/articles/PMC8328521
Autor:
Andrzej T, Slominski, Tae-Kang, Kim, Radomir M, Slominski, Yuwei, Song, Zorica, Janjetovic, Ewa, Podgorska, Sivani B, Reddy, Yuhua, Song, Chander, Raman, Edith K Y, Tang, Adrian, Fabisiak, Pawel, Brzeminski, Rafal R, Sicinski, Venkatram, Atigadda, Anton M, Jetten, Michael F, Holick, Robert C, Tuckey
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(8)
CYP11A1 and CYP27A1 hydroxylate tachysterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d645d548b56f400741231c844ecf0dfe
https://pubmed.ncbi.nlm.nih.gov/35838947
https://pubmed.ncbi.nlm.nih.gov/35838947
Autor:
Tae Kang Kim, Venkatram R. Atigadda, Russel J. Reiter, Edith K.Y. Tang, Robert C. Tuckey, Pawel Brzeminski, Andrzej Slominski, Adrian Fabisiak
Publikováno v:
ACS Food Sci Technol
Melatonin and serotonin, products of tryptophan metabolism, are endogenous neurotransmitters and hormones. We have identified and quantified these metabolites in natural honey from Australia, USA, and Poland using a Xevo G2 XS qTof LC–MS. To help e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00c44823641becffe2772a3e7982de0
https://pubmed.ncbi.nlm.nih.gov/35449872
https://pubmed.ncbi.nlm.nih.gov/35449872
Autor:
Zorica Janjetovic, Anyamanee Chaiprasongsuk, Chander Raman, Tae Kang Kim, Andrzej Slominski, Uraiwan Panich, Wei Li, Robert C. Tuckey
Publikováno v:
Free Radical Biology and Medicine. 155:87-98
UVB radiation mediates inflammatory responses causing skin damage and defects in epidermal differentiation. 1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3) interacts with the vitamin D3 receptor (VDR) to regulate inflammatory responses. Additionally, 1,25(O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb1e9f8123561fdbfca9dc3fe17a7a4
https://doi.org/10.1016/j.freeradbiomed.2020.05.016
https://doi.org/10.1016/j.freeradbiomed.2020.05.016