Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Robert C Malenka"'
Autor:
Javier Díaz-Alonso, Wade Morishita, Salvatore Incontro, Jeffrey Simms, Julia Holtzman, Michael Gill, Lennart Mucke, Robert C Malenka, Roger A Nicoll
Publikováno v:
eLife, Vol 9 (2020)
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results sup
Externí odkaz:
https://doaj.org/article/2a687e03a6294615a01f92954f148df5
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002267 (2015)
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the f
Externí odkaz:
https://doaj.org/article/164b3e3dfbf444d88099605b9b6e41a9
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41120 (2012)
The use of human embryonic stem cells (hESCs) to repair diseased or injured brain is promising technology with significant humanitarian, societal and economic impact. Parkinson's disease (PD) is a neurological disorder characterized by the loss of mi
Externí odkaz:
https://doaj.org/article/b2d2cedf22c045179597d2cd7033543e
Autor:
Valentina Martinez Damonte, Matthew B. Pomrenze, Claire E. Manning, Caroline Casper, Annie L. Wolfden, Robert C. Malenka, Julie A. Kauer
Publikováno v:
Biol Psychiatry
BACKGROUND: Neuropeptides are contained in nearly every neuron in the central nervous system and can be released not only from nerve terminals but also from somatodendritic sites. Cholecystokinin (CCK), among the most abundant neuropeptides in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9af38756f0f14fde5e06703cc8b7b1
https://doi.org/10.1016/j.biopsych.2022.06.011
https://doi.org/10.1016/j.biopsych.2022.06.011
Autor:
Rajat S. Shivacharan, Camarin E. Rolle, Daniel A. N. Barbosa, Tricia N. Cunningham, Austin Feng, Noriah D. Johnson, Debra L. Safer, Cara Bohon, Corey Keller, Vivek P. Buch, Jonathon J. Parker, Dan E. Azagury, Peter A. Tass, Mahendra T. Bhati, Robert C. Malenka, James D. Lock, Casey H. Halpern
Publikováno v:
Nature Medicine. 28:1791-1796
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3700253d33fe21ea2e6619f91239c66a
https://doi.org/10.1038/s41591-022-01941-w
https://doi.org/10.1038/s41591-022-01941-w
Autor:
Daniel A. N. Barbosa, Fiene Marie Kuijper, Jeffrey Duda, Allan R. Wang, Samuel C. D. Cartmell, Sabir Saluja, Tricia Cunningham, Rajat S. Shivacharan, Mahendra T. Bhati, Debra L. Safer, James D. Lock, Robert C. Malenka, Ricardo de Oliveira-Souza, Nolan R. Williams, Murray Grossman, James C. Gee, Jennifer A. McNab, Cara Bohon, Casey H. Halpern
Publikováno v:
Molecular Psychiatry. 27:3374-3384
The ventromedial prefrontal cortex (vmPFC) to nucleus accumbens (NAc) circuit has been implicated in impulsive reward-seeking. This disinhibition has been implicated in obesity and often manifests as binge eating, which is associated with worse treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95c69606df1a600df5ff685b848c4ee
https://doi.org/10.1038/s41380-022-01640-5
https://doi.org/10.1038/s41380-022-01640-5
Autor:
Daniel Ryskamp Rijsketic, Austen B. Casey, Daniel A. N. Barbosa, Xue Zhang, Tuuli M. Hietamies, Grecia Ramirez-Ovalle, Matthew B. Pomrenze, Casey H. Halpern, Leanne M. Williams, Robert C. Malenka, Boris D. Heifets
Publikováno v:
bioRxiv
The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbb028a2780211f796c748bbf4f67a4
https://europepmc.org/articles/PMC9980055/
https://europepmc.org/articles/PMC9980055/
Publikováno v:
Nature
Social memory—the ability to recognize and remember familiar conspecifics—is critical for the survival of an animal in its social group1,2. The dorsal CA2 (dCA2)3–5 and ventral CA1 (vCA1)6 subregions of the hippocampus, and their projection tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bb85e2f65356b47b0abcccd742f724
https://doi.org/10.1038/s41586-021-03956-8
https://doi.org/10.1038/s41586-021-03956-8
Autor:
Neir Eshel, Gavin C. Touponse, Allan R. Wang, Amber K. Osterman, Amei N. Shank, Alexandra M. Groome, Lara Taniguchi, Daniel F. Cardozo Pinto, Jason Tucciarone, Brandon S. Bentzley, Robert C. Malenka
Dopamine (DA) release in the ventral and dorsal striatum has been linked to reward processing and motivation, but there are longstanding controversies about whether DA release in these key target structures primarily reflects costs or benefits, and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87490d4d79dd07fc0c21cae9a44705b
https://doi.org/10.1101/2022.09.20.508777
https://doi.org/10.1101/2022.09.20.508777
Autor:
Belgin Yalçın, Matthew B. Pomrenze, Karen Malacon, Isabelle J. Chau, Kathryn R. Taylor, Lijun Ni, Daniel Contreras-Esquivel, Robert C. Malenka, Michelle Monje
All drugs of abuse induce long-lasting changes in synaptic transmission and neural circuit function that underlie substance use disorders. Here, we demonstrate that dopaminergic neuronal activity-regulated myelin plasticity is a key modulator of dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1dd3def7a0f700ee975f4d10e872d4e
https://doi.org/10.1101/2022.09.01.506263
https://doi.org/10.1101/2022.09.01.506263