Zobrazeno 1 - 10 of 331 pro vyhledávání: '"Robert C G Martin"'
1
Akademický článek
Irreversible electroporation augments β-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinoma
Autor: Hong Li, Yan Li, Min Tan, Shu Li, Jun Yan, Robert A Mitchell, Matthew R Woeste, Rejeena Shrestha, Anne E Geller, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Aaron Puckett, Traci Hayat, Kelly M McMasters, Robert C G Martin
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Pancreatic cancer (PC) is a challenging diagnosis that is yet to benefit from the advancements in immuno-oncologic treatments. Irreversible electroporation (IRE), a non-thermal method of tumor ablation, is used in treatment of select patie
Externí odkaz: https://doaj.org/article/81f07e10f9b0454480f2773ff2d338dc
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2
Akademický článek
The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression
Autor: Anne E. Geller, Rejeena Shrestha, Matthew R. Woeste, Haixun Guo, Xiaoling Hu, Chuanlin Ding, Kalina Andreeva, Julia H. Chariker, Mingqian Zhou, David Tieri, Corey T. Watson, Robert A. Mitchell, Huang-ge Zhang, Yan Li, Robert C. G. Martin II, Eric C. Rouchka, Jun Yan
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The advent of immunotherapy has revolutionised cancer therapeutics, but its application in the context of pancreatic ductal adenocarcinoma has been limited. Here authors explore the effect of innate trained responses to fungal β-glucan and assess it
Externí odkaz: https://doaj.org/article/60896ee968874b53b16e34db9dd843ba
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3
Akademický článek
Optimal Dosing and Patient Selection for Electrochemotherapy in Solid Abdominal Organ and Bone Tumors
Autor: Cora H. Martin, Robert C. G. Martin
Publikováno v: Bioengineering, Vol 10, Iss 8, p 975 (2023)
The primary aim of this study was to analyze studies that use electrochemotherapy (ECT) in “deep-seated” tumors in solid organs (liver, kidney, bone metastasis, pancreas, and abdomen) and understand the similarities between patient selection, onc
Externí odkaz: https://doaj.org/article/376acdfac88c40b8b4b3ce3fb2a7218d
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4
Akademický článek
Multicenter randomized controlled trial and registry study to assess the safety and efficacy of the NanoKnife® system for the ablation of stage 3 pancreatic adenocarcinoma: overview of study protocols
Autor: Govindarajan Narayanan, Malcolm M. Bilimoria, Peter J. Hosein, Zhaohui Su, Kathleen M. Mortimer, Robert C. G. Martin
Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Irreversible electroporation (IRE) is a local ablation technique utilizing high voltage, low energy direct current to create nanopores in cell membrane which disrupt homeostasis and leads to cell death. Previous reports have sugge
Externí odkaz: https://doaj.org/article/517df446e4354201898909c2250a52b5
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5
Akademický článek
Optimizing Patient Selection for Irreversible Electroporation of Locally Advanced Pancreatic Cancer: Analyses of Survival
Autor: Matthew R. Woeste, Khaleel D. Wilson, Edward J. Kruse, Matthew J. Weiss, John D. Christein, Rebekah R. White, Robert C. G. Martin
Publikováno v: Frontiers in Oncology, Vol 11 (2022)
BackgroundIrreversible electroporation (IRE) has emerged as a viable consolidative therapy after induction chemotherapy, in which this combination has improved overall survival of locally advanced pancreatic cancer (LAPC). Optimal timing and patient
Externí odkaz: https://doaj.org/article/283b0dffc21a45ee9f9574d9cfdf0fcc
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7
Akademický článek
Patient Derived Xenografts Expand Human Primary Pancreatic Tumor Tissue Availability for ex vivo Irreversible Electroporation Testing
Autor: Rebecca M. Brock, Natalie Beitel-White, Sheryl Coutermarsh-Ott, Douglas J. Grider, Melvin F. Lorenzo, Veronica M. Ringel-Scaia, Navid Manuchehrabadi, Robert C. G. Martin, Rafael V. Davalos, Irving C. Allen
Publikováno v: Frontiers in Oncology, Vol 10 (2020)
New methods of tumor ablation have shown exciting efficacy in pre-clinical models but often demonstrate limited success in the clinic. Due to a lack of quality or quantity in primary malignant tissue specimens, therapeutic development and optimizatio
Externí odkaz: https://doaj.org/article/3d4a3297f6834be5b3921b6b49b420a5
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8
Akademický článek
Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma
Autor: Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li, Robert C. G. Martin
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Hepatocellular carcinoma (HCC) is among the deadliest cancers due to its heterogeneity, contributing to chemoresistance and recurrence. Cancer stem-like cells (CSCs) are suggested to play an important role in HCC tumorigenesis. Th
Externí odkaz: https://doaj.org/article/ab7d681565a64c34bede4417858ca544
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