Zobrazeno 1 - 10
of 705
pro vyhledávání: '"Robert C Bast"'
Autor:
Olga Kim, Eun Young Park, David L Klinkebiel, Svetlana D Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E Emerson, Donna M Coffey, Sun Young Kwon, Chad J Creighton, Sanghoon Kwon, Edmund C Chang, Theodore Chiang, Alexander N Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P Nephew, Richard R Behringer, Facundo M Fernández, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C Bast, Kathy D Miller, Adam R Karpf, Jaeyeon Kim
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008808 (2020)
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the
Externí odkaz:
https://doaj.org/article/a0866ddae28348acb288e0a6cd580d54
Autor:
Johannes F. Fahrmann, Seyyed Mahmood Ghasemi, Chae Y. Han, Ranran Wu, Jennifer B. Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C. Bast, Ehsan Irajizad
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-4 (2024)
Abstract Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reduction. There remains a need to esta
Externí odkaz:
https://doaj.org/article/2b8812a211ae4ae9b4d76a096e3b31c8
Autor:
Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C. Bast, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinical and clinical studie
Externí odkaz:
https://doaj.org/article/47172d00ce154c1d97952eab624ecce7
Autor:
Shu Zhang, Zhen Lu, Weiqun Mao, Ahmed A Ahmed, Hailing Yang, Jinhua Zhou, Nicholas Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Roberto Miranda, Wei Qiao, Veera Baladandayuthapani, Zongfang Li, Anil K Sood, Jinsong Liu, Xiao-Feng Le, Robert C Bast
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131833 (2015)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ov
Externí odkaz:
https://doaj.org/article/cbbd8a5e117f459093a006bc7bf4fb97
Autor:
Xiao-Feng Le, Maria I Almeida, Weiqun Mao, Riccardo Spizzo, Simona Rossi, Milena S Nicoloso, Shu Zhang, Yun Wu, George A Calin, Robert C Bast
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41170 (2012)
Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms. Although the effects of trastuzumab on cancer cell prolifer
Externí odkaz:
https://doaj.org/article/e65c0d4d56bd4cecb7cea70628efe22c
Autor:
Dong-Joo Cheon, Ying Wang, Jian Min Deng, Zhen Lu, Lianchun Xiao, Chun-Ming Chen, Robert C Bast, Richard R Behringer
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4675 (2009)
Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian cancer (EOC) and is encoded by MUC16, a member of the mucin gene family. The biological function of CA125/MUC16 and its pote
Externí odkaz:
https://doaj.org/article/f044880ec5754fd3a31133770f24b938
Autor:
Xiaowen Liang, Sung Yun Jung, Lon Wolf Fong, Gamze Bildik, Joshua P. Gray, Weiqun Mao, Shuxing Zhang, Steven W. Millward, Alemayehu A. Gorfe, Yong Zhou, Zhen Lu, Robert C. Bast, Jr.
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108151- (2023)
Summary: DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and the prenylated C-terminus are required for DIRAS3-mediated inhibition of RAS/MAP s
Externí odkaz:
https://doaj.org/article/70cacc6af2444e3e920cbf39c22bbaf4
Autor:
Xiu Shi, Xuejiao Yu, Juan Wang, Shimin Bian, Qiutong Li, Fengqing Fu, Xinwei Zou, Lin Zhang, Robert C. Bast Jr., Zhen Lu, Lingchuan Guo, Youguo Chen, Jinhua Zhou
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2558-2574 (2022)
Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration
Externí odkaz:
https://doaj.org/article/79adc25e6b85439bb2e5bb149f97ac33
Autor:
Hawley Brown, Mia Chung, Alina Üffing, Nefeli Batistatou, Tiffany Tsang, Samantha Doskocil, Weiqun Mao, Dieter Willbold, Robert C. Bast, Zhen Lu, Oliver H. Weiergräber, Joshua A. Kritzer
Publikováno v:
Journal of the American Chemical Society. 144(32)
The LC3/GABARAP family of proteins is involved in nearly every stage of autophagy. Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which sensitizes advanced cancers to DNA-damaging chemotherapy. Here, we report the s
Publikováno v:
Holland‐Frei Cancer Medicine. :1-14