Zobrazeno 1 - 10
of 693
pro vyhledávání: '"Robert C Bast"'
Autor:
Johannes F. Fahrmann, Seyyed Mahmood Ghasemi, Chae Y. Han, Ranran Wu, Jennifer B. Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C. Bast, Ehsan Irajizad
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-4 (2024)
Abstract Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reduction. There remains a need to esta
Externí odkaz:
https://doaj.org/article/2b8812a211ae4ae9b4d76a096e3b31c8
Autor:
Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C. Bast, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinical and clinical studie
Externí odkaz:
https://doaj.org/article/47172d00ce154c1d97952eab624ecce7
Autor:
Xiaowen Liang, Sung Yun Jung, Lon Wolf Fong, Gamze Bildik, Joshua P. Gray, Weiqun Mao, Shuxing Zhang, Steven W. Millward, Alemayehu A. Gorfe, Yong Zhou, Zhen Lu, Robert C. Bast, Jr.
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108151- (2023)
Summary: DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and the prenylated C-terminus are required for DIRAS3-mediated inhibition of RAS/MAP s
Externí odkaz:
https://doaj.org/article/70cacc6af2444e3e920cbf39c22bbaf4
Autor:
Xiu Shi, Xuejiao Yu, Juan Wang, Shimin Bian, Qiutong Li, Fengqing Fu, Xinwei Zou, Lin Zhang, Robert C. Bast Jr., Zhen Lu, Lingchuan Guo, Youguo Chen, Jinhua Zhou
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2558-2574 (2022)
Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration
Externí odkaz:
https://doaj.org/article/79adc25e6b85439bb2e5bb149f97ac33
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-12 (2021)
Abstract To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cells. An acute activation of IL-6
Externí odkaz:
https://doaj.org/article/3cbf22e5819e4e2faf0144cacf392814
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-3 (2021)
Bast et al. discuss the early detection of ovarian cancer in the context of the recent UKCTOCS screening trial. The authors suggest potential reasons why the trial failed to achieve a reduction in mortality and outline next steps in the development o
Externí odkaz:
https://doaj.org/article/6ee4dc197ad9433ca667e5eb53292f86
Autor:
Zhen Lu, Weiqun Mao, Hailing Yang, Janice M. Santiago-O’Farrill, Philip J. Rask, Jayanta Mondal, Hu Chen, Cristina Ivan, Xiuping Liu, Chang-Gong Liu, Yuanxin Xi, Kenta Masuda, Eli M. Carrami, Meng Chen, Yitao Tang, Lan Pang, David S. Lakomy, George A. Calin, Han Liang, Ahmed A. Ahmed, Hariprasad Vankayalapati, Robert C. Bast Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Poly(ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells with homologous recombination DNA repair deficiency caused by mutatio
Externí odkaz:
https://doaj.org/article/2135cd9f007a441e941965d7b77e03eb
Autor:
Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett, Nina Wietek, Matteo Morotti, Kay Chong, Mohammad KaramiNejadRanjbar, Christos E. Zois, Sunanda Dhar, Salma El-Sahhar, Leticia Campo, Sarah P. Blagden, Stephen Damato, Pubudu N. Pathiraja, Shibani Nicum, Fergus Gleeson, Alexandros Laios, Abdulkhaliq Alsaadi, Laura Santana Gonzalez, Takeshi Motohara, Ashwag Albukhari, Zhen Lu, Robert C. Bast Jr., Adrian L. Harris, Christer S. Ejsing, Robin W. Klemm, Christopher Yau, Tatjana Sauka-Spengler, Ahmed Ashour Ahmed
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. He
Externí odkaz:
https://doaj.org/article/aed4f3377d6c477db1f5a1a0d72b84ea
Autor:
Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2005bec4130b42fcbb14be00909fa2b7
Autor:
Olga Kim, Eun Young Park, David L Klinkebiel, Svetlana D Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E Emerson, Donna M Coffey, Sun Young Kwon, Chad J Creighton, Sanghoon Kwon, Edmund C Chang, Theodore Chiang, Alexander N Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P Nephew, Richard R Behringer, Facundo M Fernández, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C Bast, Kathy D Miller, Adam R Karpf, Jaeyeon Kim
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008808 (2020)
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the
Externí odkaz:
https://doaj.org/article/a0866ddae28348acb288e0a6cd580d54