Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Robert C, Tuckey"'
Autor:
Zorica Janjetovic, Shariq Qayyum, Sivani B. Reddy, Ewa Podgorska, S. Gates Scott, Justyna Szpotan, Alisa A. Mobley, Wei Li, Vijay K. Boda, Senthilkumar Ravichandran, Robert C. Tuckey, Anton M. Jetten, Andrzej T. Slominski
Publikováno v:
Cells, Vol 13, Iss 3, p 239 (2024)
We investigated multiple signaling pathways activated by CYP11A1-derived vitamin D3 hydroxymetabolites in human skin fibroblasts by assessing the actions of these molecules on their cognate receptors and by investigating the role of CYP27B1 in their
Externí odkaz:
https://doaj.org/article/49e273a96d6b44959945a696dfc09806
Autor:
Andrzej T. Slominski, Tae-Kang Kim, Shariq Qayyum, Yuwei Song, Zorica Janjetovic, Allen S. W. Oak, Radomir M. Slominski, Chander Raman, Joanna Stefan, Carlos A. Mier-Aguilar, Venkatram Atigadda, David K. Crossman, Andriy Golub, Yaroslav Bilokin, Edith K. Y. Tang, Jake Y. Chen, Robert C. Tuckey, Anton M. Jetten, Yuhua Song
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking sco
Externí odkaz:
https://doaj.org/article/25793fb5b8704b48b8b033ea0ef380e3
Autor:
Arnold E. Postlethwaite, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal K. Bhattacharya, Linda K. Myers, David D. Brand, Andrzej T. Slominski
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 i
Externí odkaz:
https://doaj.org/article/fa1661234a1b494fb2fa119c0157414a
Autor:
Linda K. Myers, Michael Winstead, John D. Kee, Jeoungeun J. Park, Sicheng Zhang, Wei Li, Ae-Kyung Yi, John M. Stuart, Edward F. Rosloniec, David D. Brand, Robert C. Tuckey, Andrzej T. Slominski, Arnold E. Postlethwaite, Andrew H. Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13342 (2021)
Vitamin D plays a crucial role in regulation of the immune response. However, treatment of autoimmune diseases with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] doses sufficient to be effective is prohibitive due to its calcemic and toxic effects. We use t
Externí odkaz:
https://doaj.org/article/6c8ae4b7289f4d74854e8298c05abd98
Autor:
Monica L. Brown Lobbins, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Imara-Safi O. Scott, Linda K. Myers, Arnold E. Postlethwaite
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 367 (2021)
We previously demonstrated that the non-calcemic pregnacalciferol (pD) analog 17,20S (OH)2pD suppressed TGF-β1-induced type I collagen production in cultured normal human dermal fibroblasts. In the present studies, we examined fibroblasts cultured f
Externí odkaz:
https://doaj.org/article/c7bce4db2efe4d68b05ba81c56c86282
Autor:
Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Stuart G. Jarrett, John A. D'Orazio, Michael F. Holick, Edith K.Y. Tang, Robert C. Tuckey, Uraiwan Panich, Wei Li, Andrzej T. Slominski
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
We tested whether novel CYP11A1-derived vitamin D3- and lumisterol-hydroxyderivatives, including 1,25(OH)2D3, 20(OH)D3, 1,20(OH)2D3, 20,23(OH)2D3, 1,20,23(OH)3D3, lumisterol, 20(OH)L3, 22(OH)L3, 20,22(OH)2L3, and 24(OH)L3, can protect against UVB-ind
Externí odkaz:
https://doaj.org/article/f0a5b634dfe44aa4bdf6e2e7a315bd20
Autor:
Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Cynthia J. Schwartz, Robert C. Tuckey, Edith K. Y. Tang, Chander Raman, Uraiwan Panich, Andrzej T. Slominski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9374 (2020)
Lumisterol (L3) is a stereoisomer of 7-dehydrocholesterol and is produced through the photochemical transformation of 7-dehydrocholesteol induced by high doses of UVB. L3 is enzymatically hydroxylated by CYP11A1, producing 20(OH)L3, 22(OH)L3, 20,22(O
Externí odkaz:
https://doaj.org/article/dda599985b99499ba8b8accb57b2e6ac
Autor:
Anna A. Brożyna, Tae-Kang Kim, Marzena Zabłocka, Wojciech Jóźwicki, Junming Yue, Robert C. Tuckey, Anton M. Jetten, Andrzej T. Slominski
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3541 (2020)
Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors γ and α (RORγ and RORα), show anticancer properties. Since pathological conditions are characterized by disturbances in the expressi
Externí odkaz:
https://doaj.org/article/ae16f12994194bf988ea95cc1db44f8b
Autor:
Tae-Kang Kim, Venkatram Atigadda, Pawel Brzeminski, Adrian Fabisiak, Edith K. Y. Tang, Robert C. Tuckey, Andrzej T. Slominski
Publikováno v:
Molecules, Vol 25, Iss 11, p 2583 (2020)
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP
Externí odkaz:
https://doaj.org/article/7b8cb16eafeb4353bb7f2cf2744c8af2
Autor:
Tomasz Wasiewicz, Paulina Szyszka, Miroslawa Cichorek, Zorica Janjetovic, Robert C. Tuckey, Andrzej T. Slominski, Michal A. Zmijewski
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 6645-6667 (2015)
Deregulated melanogenesis is involved in melanomagenesis and melanoma progression and resistance to therapy. Vitamin D analogs have anti-melanoma activity. While the hypercalcaemic effect of the active form of Vitamin D (1,25(OH)2D3) limits its thera
Externí odkaz:
https://doaj.org/article/a0fd3fb2aeac4138b022425b144bcb2c