Zobrazeno 1 - 10 of 321 pro vyhledávání: '"Robert C, Newton"'
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Akademický článek
Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma
Autor: Geoffrey T. Gibney, Omid Hamid, Jose Lutzky, Anthony J. Olszanski, Tara C. Mitchell, Thomas F. Gajewski, Bartosz Chmielowski, Brent A. Hanks, Yufan Zhao, Robert C. Newton, Janet Maleski, Lance Leopold, Jeffrey S. Weber
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Epacadostat is a potent inhibitor of the immunosuppressive indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. We present phase 1 results from a phase 1/2 clinical study of epacadostat in combination with ipilimumab, an anti-cytotoxic T-
Externí odkaz: https://doaj.org/article/5099b0af01e64192a7b84fc9a960caa6
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Data from Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib
Autor: Timothy C. Burn, Davide Melisi, Camilla Zecchetto, Luis Féliz, Huiling Zhen, Robert C. Newton, Sherry Owens, Luc Friboulet, Antoine Hollebecque, Ian M. Silverman
Pemigatinib, a selective FGFR1–3 inhibitor, has demonstrated antitumor activity in FIGHT-202, a phase II study in patients with cholangiocarcinoma harboring FGFR2 fusions/rearrangements, and has gained regulatory approval in the United States. Elig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da035ad9df6005abe4dff9fbc887b35c
https://doi.org/10.1158/2159-8290.c.6548233.v1
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7
Young and Old Granulites: A Volatile Connection
Autor: Robert C. Newton
Publikováno v: The Journal of Geology. 128:395-413
Granulite facies metamorphism of the lower crust has decreased in scale since the Late Archean, but many of its definitive features have persisted: (1) Punctuated, sometimes relatively shor...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48b3a2448a6e38f8dceaf191565a1d85
https://doi.org/10.1086/711026
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Diopside, enstatite and forsterite solubilities in H2O and H2O-NaCl solutions at lower crustal and upper mantle conditions
Autor: Ruiguang Pan, Jeremy Wykes, Catherine A. Macris, Craig E. Manning, Robert C. Newton
Publikováno v: Geochimica et Cosmochimica Acta. 279:119-142
The interaction of fluids with rock-forming minerals plays an important role in the chemical evolution of mafic and ultramafic rocks in the lower crust and upper mantle. Recent work highlights the importance of salt-rich fluids in element transport i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c00df143003df0ebe76bfc22978fda8
https://doi.org/10.1016/j.gca.2020.03.035
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28 Retrospective pooled analysis of epacadostat clinical studies identifies doses required for maximal pharmacodynamic effect in anti-PD-1 combination studies
Autor: Michael Smith, Sherry Owens, Janet Maleski, Xiaohua Gong, Lance Leopold, Robert C. Newton, Chuan Tian
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background IDO1 is the initial rate-limiting enzyme in one breakdown pathway of tryptophan. It reduces tryptophan levels and generates metabolites (e.g., kynurenine [KYN]) that contribute to tumor-associated immune suppression. Epacadostat (EPA) is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb39c1ff168a28c4ba0a824085522195
https://doaj.org/article/621844b1162a4f868df3e22d0bc1d733
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