Zobrazeno 1 - 10
of 558
pro vyhledávání: '"Robert C, Murphy"'
Autor:
Valerie B. O’Donnell, Nils H. Schebb, Ginger L. Milne, Michael P. Murphy, Christopher P. Thomas, Dieter Steinhilber, Stacy L. Gelhaus, Hartmut Kühn, Michael H. Gelb, Per-Johan Jakobsson, Ian A. Blair, Robert C. Murphy, Bruce A. Freeman, Alan R. Brash, Garret A. FitzGerald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/be32bdf8db4a483a9d4567d68f0e996c
Autor:
Mariya Misheva, Konstantinos Kotzamanis, Luke C. Davies, Victoria J. Tyrrell, Patricia R. S. Rodrigues, Gloria A. Benavides, Christine Hinz, Robert C. Murphy, Paul Kennedy, Philip R. Taylor, Marcela Rosas, Simon A. Jones, James E. McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A. Czubala, Mark Gurney, Maceler Aldrovandi, Sven W. Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A. White, Valerie B. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a m
Externí odkaz:
https://doaj.org/article/a3d11671abcf4409a6bdffc0da87c0f3
Akademický článek
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Autor:
Zack Saud, Victoria J. Tyrrell, Andreas Zaragkoulias, Majd B. Protty, Evelina Statkute, Anzelika Rubina, Kirsten Bentley, Daniel A. White, Patricia Dos Santos Rodrigues, Robert C. Murphy, Harald Köfeler, William J. Griffiths, Jorge Alvarez-Jarreta, Richard William Brown, Robert G. Newcombe, James Heyman, Manon Pritchard, Robert WJ. Mcleod, Arvind Arya, Ceri-Ann Lynch, David Owens, P Vince Jenkins, Niklaas J. Buurma, Valerie B. O’Donnell, David W. Thomas, Richard J. Stanton
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100208- (2022)
The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its molecular composition is undetermined. Addressing this knowledge gap could support the design of antiviral agents
Externí odkaz:
https://doaj.org/article/6b2447ff65c14140a877f16e61623047
Autor:
Gerhard Liebisch, Eoin Fahy, Junken Aoki, Edward A. Dennis, Thierry Durand, Christer S. Ejsing, Maria Fedorova, Ivo Feussner, William J. Griffiths, Harald Köfeler, Alfred H. Merrill, Jr., Robert C. Murphy, Valerie B. O'Donnell, Olga Oskolkova, Shankar Subramaniam, Michael J.O. Wakelam, Friedrich Spener
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1539-1555 (2020)
A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid struct
Externí odkaz:
https://doaj.org/article/2bd36b12c88941a5aed54ffa6bbb5b4e
Autor:
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Dieter Steinhilber
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 1
Externí odkaz:
https://doaj.org/article/4d550b6401b044cfacb01d9180ee3c13
Autor:
Robert C. Murphy, Giancarlo Folco
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 219-226 (2019)
Leukotrienes (LTs) are autacoids derived from the precursor arachidonic acid (AA) via the action of five-lipoxygenase (5-LO). When inflammatory cells are activated, 5-LO translocates to the nuclear membrane to initiate oxygenation of AA released by c
Externí odkaz:
https://doaj.org/article/106c69d856534f84a896adedaca5b4a8
Autor:
Victoria J. Tyrrell, Faraz Ali, William E. Boeglin, Robert Andrews, James Burston, James C. Birchall, John R. Ingram, Robert C. Murphy, Vincent Piguet, Alan R. Brash, Valerie B. O'Donnell, Christopher P. Thomas
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100094- (2021)
A complex assembly of lipids including fatty acids, cholesterol, and ceramides is vital to the integrity of the mammalian epidermal barrier. The formation of this barrier requires oxidation of the substrate fatty acid, linoleic acid (LA), which is in
Externí odkaz:
https://doaj.org/article/da95d04e315a448bb3ecd72b7c0d5f1e
Autor:
Toshiaki Okuno, Miguel A. Gijón, Simona Zarini, Sarah A. Martin, Robert M. Barkley, Christopher A. Johnson, Mai Ohba, Takehiko Yokomizo, Robert C. Murphy
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 542-549 (2018)
The remodeling of PUFAs by the Lands cycle is responsible for the diversity of phospholipid molecular species found in cells. There have not been detailed studies of the alteration of phospholipid molecular species as a result of serum starvation or
Externí odkaz:
https://doaj.org/article/f75350d1634a4f01a6b888f4437716dc
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 926-933 (2017)
Lipids play a central role in lung physiology and pathology; however, a comprehensive lipidomic characterization of human pulmonary cells relevant to disease has not been performed. The cells involved in lung host defense, including alveolar macropha
Externí odkaz:
https://doaj.org/article/79b95e45980045c58dd8d6b7455e5e9b