Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Robert C, Bauer"'
Autor:
Marcella E. O’Reilly, Sebastian Ho, Johana Coronel, Lucie Zhu, Wen Liu, Chenyi Xue, Eunyoung Kim, Esther Cynn, Caio V. Matias, Rajesh Kumar Soni, Chen Wang, Iuliana Ionita-Laza, Robert C. Bauer, Leila Ross, Yiying Zhang, Silvia Corvera, Susan K. Fried, Muredach P. Reilly
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114240- (2024)
Summary: Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNA
Externí odkaz:
https://doaj.org/article/577c9a29704b4b8ca143497013362bb5
Autor:
Leroy C. Joseph, Jianting Shi, Quynh N. Nguyen, Victoria Pensiero, Chris Goulbourne, Robert C. Bauer, Hanrui Zhang, John P. Morrow
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104184- (2022)
Summary: The response of vital organs to different types of nutrition or diet is a fundamental question in physiology. We examined the cardiac response to 4 weeks of high-fat diet in mice, measuring cardiac metabolites and mRNA. Metabolomics showed d
Externí odkaz:
https://doaj.org/article/46b5515b638f46839e59f57ba806af4d
Autor:
Elizabeth E. Ha, Gabriella I. Quartuccia, Ruifeng Ling, Chenyi Xue, Rhoda A. Karikari, Antonio Hernandez-Ono, Krista Y. Hu, Caio V. Matias, Rami Imam, Jian Cui, Natalia S. Pellegata, Stephan Herzig, Anastasia Georgiadi, Rajesh K. Soni, Robert C. Bauer
Publikováno v:
Molecular Metabolism, Vol 56, Iss , Pp 101412- (2022)
Objective: Multiple genome-wide association studies (GWAS) have identified SNPs in the 8q24 locus near TRIB1 that are significantly associated with plasma lipids and other markers of cardiometabolic health, and prior studies have revealed the roles o
Externí odkaz:
https://doaj.org/article/76103e6b00d44b889858a9b2c8ff57bc
Purpose: Dasatinib and nilotinib are active in imatinib-resistant chronic myelocytic leukemia (CML) and many patients undergo sequential treatment. We aimed at modeling sequential tyrosine kinase inhibitor (TKI) resistance in vitro to compare the seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5c9d8cee2b4f8fd3318cf21200100f
https://doi.org/10.1158/1078-0432.c.6522483
https://doi.org/10.1158/1078-0432.c.6522483
PDF File - 120K, BCR-ABL kinase domain mutations recovered in the sequential screen with IC50-values for imatinib, dasatinib and nilotinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5479597be65e3cd8392bc335a78e7a6
https://doi.org/10.1158/1078-0432.22452459.v1
https://doi.org/10.1158/1078-0432.22452459.v1
Autor:
Fang Li, Elise Flynn, Jianting Shi, Xun Wu, Ziyi Wang, Chenyi Xue, Haoxiang Cheng, Yujiao Meng, Jian Cui, Yizhou Zhu, Annie Rozenblyum, Jeana Chun, Antonio Hernandez-Ono, Babak Razani, Marit Westerterp, Robert C Bauer, Yousin Suh, Ke Hao, Tuuli Lappalainen, Hanrui Zhang
BackgroundGenome-wide association studies revealed a robust association between genetic variants in theLIPA(lysosomal acid lipase) gene and coronary artery diseases (CAD), but not lipid traits. QTL studies support that the risk alleles ofLIPACAD vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85225488251f9adedfa715eb4617466
https://doi.org/10.1101/2022.11.12.516293
https://doi.org/10.1101/2022.11.12.516293
Autor:
Robert C. Bauer, Krista Y. Hu
Publikováno v:
Curr Opin Lipidol
PURPOSE OF REVIEW The pseudokinase Tribbles-1 (TRIB1) remains the focus of intense research since genome-wide association studies (GWAS) associated it with multiple cardiometabolic traits in humans, including plasma lipids and atherosclerosis. This r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5974db7245ef92b85663d651497c38e9
https://doi.org/10.1097/mol.0000000000000748
https://doi.org/10.1097/mol.0000000000000748
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Single Cell RNA Sequencing (scRNA-seq) has proven to be a powerful technique to uncover heterogeneity from otherwise homogeneous tissues. Multiple studies have utilized scRNA-seq to examine the composition of atherosclerotic plaques in both humans an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ceb37d1189694cf861eb97169ab1a5c
https://doi.org/10.1161/atvb.42.suppl_1.524
https://doi.org/10.1161/atvb.42.suppl_1.524
Autor:
Caio V Matias, Kavita S Jadhav, Elizabeth H Ha, Marek Nagiec, Adam P Skepner, Rajesh K Soni, Robert C Bauer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
The gene tribbles pseudokinase 1 ( TRIB1 ) has been repeatedly linked to multiple human cardiometabolic traits through genome-wide association studies, including coronary artery disease, plasma cholesterol and triglycerides, and circulating liver tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43e3cc75201c614808032aade650a54
https://doi.org/10.1161/atvb.41.suppl_1.p158
https://doi.org/10.1161/atvb.41.suppl_1.p158
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
Genome-wide association studies in humans link ADAMTS7 with coronary artery disease. Subsequent studies in mice showed ADAMTS7 to be proatherogenic, as whole-body knockout (KO) reduced atherosclerosis independent of lipid-lowering. Further studies sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::897b1a0ac493ef78e8095e565f8a775f
https://doi.org/10.1161/atvb.41.suppl_1.103
https://doi.org/10.1161/atvb.41.suppl_1.103