Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Robert Bruce Russell"'
Increasingly available genomic sequencing data are exploited to identify genes and variants contributing to diseases, particularly cancer. Traditionally, methods to find such variants have relied heavily on allele frequency and/or familial history, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6432be67ea15a81e95f2ccf8ac3646b
Wiley Online Library
Wiley Online Library
Genetic variants are currently a major component of system-wide investigations into biological function or disease. Approaches to select variants (often out of thousands of candidates) that are responsible for a particular phenomenon have many clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762c12e410716fdd4400f101b865155f
http://essays.biochemistry.org/content/62/4/575.full-text.pdf
http://essays.biochemistry.org/content/62/4/575.full-text.pdf
Publikováno v:
FEBS Letters. 582:1271-1275
The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d103e557031fa0a66d87ae3e3d22a0
https://doi.org/10.1016/j.febslet.2008.02.027
https://doi.org/10.1016/j.febslet.2008.02.027
Autor:
Robert Bruce Russell
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Classification is central to many studies of protein structure, function, and evolution. This article presents a strategy for classifying protein three-dimensional structures. Methods for and issues related to secondary structure, domain, and class a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9fd8bd44d40818ca2fb38019b632c5
https://doi.org/10.1007/s12033-007-0032-2
https://doi.org/10.1007/s12033-007-0032-2
Autor:
Robert Bruce Russell, Patrick Aloy
Publikováno v:
FEBS Letters. 579:1854-1858
Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca4e8e769095106fb367fea7a1b0923
https://doi.org/10.1016/j.febslet.2005.02.014
https://doi.org/10.1016/j.febslet.2005.02.014
Publikováno v:
Nucleic Acids Research
The database of 3D Interacting Domains (3did) is a collection of domain-domain interactions in proteins for which high-resolution three-dimensional structures are known. 3did exploits structural information to provide critical molecular details neces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b751590fe694ebcc0a31b39a046930
http://europepmc.org/articles/PMC539991
http://europepmc.org/articles/PMC539991
Publikováno v:
Proteins: Structure, Function, and Genetics. 53:436-456
We present the assessment of CASP5 predictions in the new fold category. For coordinate predictions, we considered five targets with new folds and eight lying on the fold recognition borderline. We performed detailed visual and numerical comparisons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e866f8d1d0b9075519978949e463318d
https://doi.org/10.1002/prot.10546
https://doi.org/10.1002/prot.10546
Autor:
Patrick Aloy, Robert Bruce Russell
Publikováno v:
Comparative and Functional Genomics
Comparative and Functional Genomics, Vol 4, Iss 4, Pp 410-415 (2003)
Comparative and Functional Genomics, Vol 4, Iss 4, Pp 410-415 (2003)
Protein interactions are central to most biological processes, and are currently the subject of great interest. Yet despite the many recently developed methods for interaction discovery, little attention has been paid to one of the best sources of da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dd7ca5fa2af4c077b8db35b2f89778
http://europepmc.org/articles/PMC2447374
http://europepmc.org/articles/PMC2447374
Autor:
Patrick Aloy, Robert Bruce Russell
Publikováno v:
Trends in Biochemical Sciences. 27:633-638
Interaction discovery methods, such as the two-hybrid system and affinity purification, suggest thousands of protein–protein interactions. Structural biology provides atomic details for many interactions but, to date, there has been limited discuss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4fc4293d7feb33e326455a4f46df9e
https://doi.org/10.1016/s0968-0004(02)02204-1
https://doi.org/10.1016/s0968-0004(02)02204-1
Autor:
Patrick Aloy, Robert Bruce Russell
Publikováno v:
Proceedings of the National Academy of Sciences. 99:5896-5901
Protein–protein interactions are central to most biological processes. Although much recent effort has been put into methods to identify interacting partners, there has been a limited focus on how these interactions compare with those known from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5beb098aa678e1f48a21d2a933709fa
https://doi.org/10.1073/pnas.092147999
https://doi.org/10.1073/pnas.092147999