Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert Brendza"'
Autor:
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105969- (2023)
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates. As DA
Externí odkaz:
https://doaj.org/article/f3994bb352724f55b0845dad814ba7b9
Autor:
Martin Weber, Sang-Won Min, Tom Truong, Jeffrey Hung, Stephanie Dale, Mike Reichelt, Savita Ubhayakar, Carol Cain-Hom, Miriam Baca, Zhiyu Jiang, Qingling Li, Robert Brendza, Han Lin, Chung Kung, William F. Forrest, Cristine Quiason-Huynh, Wendy Sandoval, Buyun Chen, Yuzhong Deng, Amy Easton, Oded Foreman, Abdoulaye Sene, Baris Bingol
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impa
Externí odkaz:
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Autor:
Robert Brendza, Han Lin, Kimberly Stark, Oded Foreman, Janet Tao, Andrew Pierce, Hai Ngu, Kimberle Shen, Amy E. Easton, Tushar Bhangale, Diana Chang, Baris Bingol, Brad A. Friedman
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105494- (2021)
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkins
Externí odkaz:
https://doaj.org/article/97c7b8fae8394304ad382e3b998c63c0
Autor:
Seung-Hye Lee, Claire E. Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A. Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V. Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J. Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalon
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1690-1700 (2016)
The spread of tau pathology correlates with cognitive decline in Alzheimer’s disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promote micro
Externí odkaz:
https://doaj.org/article/b163d59ffd12448093ab9975aa14a02e
Autor:
Jeffrey Hung, Buyun Chen, Robert Brendza, Zhiyu Jiang, William F. Forrest, Cristine M. Quiason-Huynh, Tom Truong, Savita Ubhayakar, Abdoulaye Sene, Carol Cain-Hom, Mike Reichelt, Oded Foreman, Martin Weber, Stephanie Dale, Amy Easton, Han Lin, Sang-Won Min, Qingling Li, Chung Kung, Baris Bingol, Miriam Baca, Yuzhong Deng, Wendy Sandoval
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Mutations in the GBA1 gene encoding glucocerebrosidase (GCase) are linked to Gaucher (GD) and Parkinson’s Disease (PD). Since some GD and PD patients develop ocular phenotypes, we determined whether ocular phenotypes might result from impaired GCas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc9a3a93b3b95a4d22a4ff91dd3c1a3
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
https://doaj.org/article/08dc67cbf02f4f9ab4c713dcac4d0867
Autor:
Jeffrey Eastham-Anderson, Oded Foreman, Kai H. Barck, Luke Xie, Andrew S. Peterson, Brent S. McKenzie, Richard A.D. Carano, Wyne P. Lee, Georgios Koukos, Robert Brendza
Publikováno v:
American Journal of Physiology-Renal Physiology. 316:F76-F89
Glomeruli number and size are important for determining the pathogenesis of glomerular disease, chronic kidney disease, and hypertension. Moreover, renal injury can occur in specific cortical layers and alter glomerular spatial distribution. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eed20af5c696c76cb2b0fe7ea366419
https://doi.org/10.1152/ajprenal.00331.2018
https://doi.org/10.1152/ajprenal.00331.2018
Autor:
Gautham K. Rao, Stephen P. Schauer, Edmond Teng, Joseph Bravo, Reina N. Fuji, Andrea Pfeifer, Yong Ying, Kimberly Scearce-Levie, Jessica Couch, Hilda Solanoy, Paul T. Manser, Andreas Muhs, Han Lin, Daniela Bumbaca Yadav, Oded Foreman, Dongping He, James A. Ernst, Flavia Brunstein, Hai Ngu, Michael C. M. Kwok, Maria Pihlgren, Oskar Adolfsson, Mira Blendstrup, William B. Smith, Priya Chandra, Akash Datwani, Michael Keeley, Danielle DiCara, Robert Brendza, Yanmei Lu, Julien Lafrance-Vanasse, Corinne Foo-Atkins, Jasvinder K. Atwal, Isidro Hötzel, Seung-Hye Lee, Kristin R. Wildsmith, Ruby Chan, Helen Booler, Rich Erickson, Barthélemy Demeule, Geoffrey A. Kerchner, Wilman Luk, Gai Ayalon
Publikováno v:
Science Translational Medicine. 13
Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate with disease course and severity better than other disease markers to da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8226f0212aa58c81fd5ec5abd2b2f7
https://doi.org/10.1126/scitranslmed.abb2639
https://doi.org/10.1126/scitranslmed.abb2639
Autor:
Janet Tao, Amy Easton, Diana Chang, Hai Ngu, Oded Foreman, Tushar Bhangale, Andrew A. Pierce, Kimberle Shen, Robert Brendza, Han Lin, Baris Bingol, Kimberly L. Stark, Brad A. Friedman
Publikováno v:
Neurobiology of Disease, Vol 159, Iss, Pp 105494-(2021)
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ecd605f3960aeb7498922e63a5cec8
https://pubmed.ncbi.nlm.nih.gov/34464706
https://pubmed.ncbi.nlm.nih.gov/34464706
Autor:
Joy S. Tea, Oded Foreman, Sara L. Dominguez, Hai Ngu, Amy Easton, Timothy K. Earr, Robert Brendza, Jose Imperio, Baris Bingol, Joshua D. Webster, Domagoj Vucic, Kim Stark, Eugene Varfolomeev
Publikováno v:
Cell Death Differ
RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6202ba1019dfe8ee4603903ffbfaa17
https://pubmed.ncbi.nlm.nih.gov/32994544
https://pubmed.ncbi.nlm.nih.gov/32994544
Autor:
Ryan J. Watts, Oded Foreman, Maria Pihlgren, Ruby Chan, Valerie Gafner, Karpagam Srinivasan, David V. Hansen, Hai Ngu, Oskar Adolfsson, Jasvinder K. Atwal, Yanmei Lu, Robert Brendza, Andreas Muhs, Han Lin, Gai Ayalon, Seung-Hye Lee, Andrea Pfeifer, Kimberly Scearce-Levie, James A. Ernst, Daniela Bumbaca, Hilda Solanoy, Danielle DiCara, Isidro Hötzel, Claire E. Le Pichon
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1690-1700 (2016)
SummaryThe spread of tau pathology correlates with cognitive decline in Alzheimer’s disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4556d04844f372b30085ce4e4ff08804
http://www.sciencedirect.com/science/article/pii/S2211124716308683
http://www.sciencedirect.com/science/article/pii/S2211124716308683