Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robert Boigegrain"'
Publikováno v:
Journal of the Chemical Society. Perkin Transactions 2. (12):2639-2646
Neurotensin has a wide range of pharmacological effects in peripheral tissues and in the central nervous system. The crystal structures of two potent and selective neurotensin receptor antagonists, SR 48692 (I) and SR 48527 (II) have been determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9271ee121905b821fc86ae97e3e366b9
https://researchportal.unamur.be/en/publications/e0d1f8e2-6755-4169-96d2-4b84e0a8e94f
https://researchportal.unamur.be/en/publications/e0d1f8e2-6755-4169-96d2-4b84e0a8e94f
Autor:
Robert Boigegrain, Jean-Paul Kan, Dominique Olliero, Roger Brodin, Philippe Soubrié, Jean-Jacques Bourguignon, Camille-Georges Wermuth
Publikováno v:
European Journal of Medicinal Chemistry. 30:175s-185s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2000e0a8b20cd451eed70faba8b007fa
https://doi.org/10.1016/s0223-5234(23)00123-x
https://doi.org/10.1016/s0223-5234(23)00123-x
Autor:
Robert Boigegrain, C Gueudet, Danielle Gully, R Leyris, M. Poncelet, F. Jeanjean, Michel Heaulme, Aline Brouard, J C Molimard, M Canton
Publikováno v:
Proceedings of the National Academy of Sciences. 90:65-69
We describe the characteristics of SR 48692, a selective, nonpeptide antagonist of the neurotensin receptor. In vitro, this compound competitively inhibits 125I-labeled neurotensin binding to the high-affinity binding site present in brain tissue fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96749d6f61ebb7d100d90c63f125b4c
https://doi.org/10.1073/pnas.90.1.65
https://doi.org/10.1073/pnas.90.1.65
Autor:
Danielle Gully, Bernard Labeeuw, Luc Quere, Geraldine Longfils, Robert Boigegrain, François Durant
Publikováno v:
ChemInform. 29
SR 142948 is an original and extremely potent neurotensin receptor antagonist developed in a promising approach to novel antipsychotic drugs. The X-ray structure was elucidated and compared to SR 48692 and levocabastine, providing new informations ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a503781ca3103bda119e83df2d0edf
https://doi.org/10.1002/chin.199827020
https://doi.org/10.1002/chin.199827020
Autor:
Robert Boigegrain, Roger Brodin, Philippe Soubrié, Camille G. Wermuth, Jean-Paul Kan, Jean-Jacques Bourguignon, Rémy Hoffmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:833-838
The development of an aminopyridazine lead structure (minaprine) yielded compound SR 46559 A 3-[N-(2-diethyl-amino-2-methylpropyl)-6-phenyl-5-propyl] pyridazinamine sesquifumarate, a novel and potent muscarinic agonist with no cholinergic syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9661b5e682e1cf56494ef26bfe1630c5
https://doi.org/10.1016/s0960-894x(00)80540-5
https://doi.org/10.1016/s0960-894x(00)80540-5
Autor:
Bernard Labeeuw, Luc Quere, Robert Boigegrain, Geraldine Longfils, François Durant, Danielle Gully
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(6)
SR 142948 is an original and extremely potent neurotensin receptor antagonist developed in a promising approach to novel antipsychotic drugs. The X-ray structure was elucidated and compared to SR 48692 and levocabastine, providing new informations ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66e7144337f138d1f4d0a03b09dc580
https://pubmed.ncbi.nlm.nih.gov/9871577
https://pubmed.ncbi.nlm.nih.gov/9871577
Autor:
Jean-Paul Kan, Régis Steinberg, Florence Oury-Donat, Jean-Claude Michaud, Oliver Thurneyssen, Jean-Paul Terranova, Christiane Gueudet, Josiane Souilhac, Roger Brodin, Robert Boigegrain, Camille-Georges Wermuth, Paul Worms, Philippe Soubrié, Gérard Le Fur
Publikováno v:
Psychopharmacology. 112(2-3)
The cholinergic activities of SR 46559A, 3-[N-(2 diethyl-amino-2-methylpropyl)-6-phenyl-5-propyl] pyridazinamine sesquifumarate, have been investigated in vitro and in vivo, in rodents. Using rat brain cortical membranes, SR 46559A was a competitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d2db4a03efa5c6ca4c0110dd17663b
https://pubmed.ncbi.nlm.nih.gov/7871023
https://pubmed.ncbi.nlm.nih.gov/7871023
Autor:
Patrick Kitabgi, G Le Fur, Danielle Gully, Robert Boigegrain, William Rostène, J P Maffrand, Michel Heaulme, Martine Poncelet, Aline Brouard, Catherine Labbé-Jullié
Publikováno v:
Neuropeptides. 24:241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3484104c9c9636d4417bbd01c548518
https://doi.org/10.1016/0143-4179(93)90262-9
https://doi.org/10.1016/0143-4179(93)90262-9
Autor:
Philippe Soubrie, Patrick Kitabgi, Danielle Gully, William Rostène, G. Le Fur, J P Maffrand, Robert Boigegrain
Publikováno v:
Drugs of the Future. 18:1137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5a377fe17943cfd6a4be500d0a521a
https://doi.org/10.1358/dof.1993.018.12.233925
https://doi.org/10.1358/dof.1993.018.12.233925
Publikováno v:
Journal of Heterocyclic Chemistry. 18:727-734
Des aryl-4 thieno[2,3-c]pyridines et des aryl-7 thieno[3,2-c]pyridines ont ete respectivement obtenues par chauffage dans l'acide polyphosphorique de [thenyl-2 amino]-2 aryl-1 ethanols ou propanols et de [thenyl-3 amino]-2 aryl-1 ethanols ou propanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13dc664846c8597d2ed53f6c3756ffaa
https://doi.org/10.1002/jhet.5570180418
https://doi.org/10.1002/jhet.5570180418