Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert Blackie"'
Autor:
David J. Kerr, Jim Cassidy, Richard Poyner, Leonard W. Seymour, D. R. Ferry, Hilary Calvert, Ruth Duncan, Andreas G. Schätzlein, Stuart Hesslewood, Duncan I. Jodrell, Daniel Rea, Robert Blackie, Adele Robbins, Michael J. Lind, Maggie Whitlock, Donald Bissett, Sally Burtles, Christopher M Boivin, Chris Twelves
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled with 5-fold decreased anthracycline toxicity in chemotherapy-refractory patients. Here we report phase H studies using a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e00789a5e76ad68835ad6a6ec539a96
https://doi.org/10.3892/ijo_00000293
https://doi.org/10.3892/ijo_00000293
Autor:
J. Hughes, David J. Kerr, G Burnside, R. N. Scott, D.S. Byrne, Rona M. MacKie, A J McKay, Robert Blackie
Publikováno v:
British Journal of Cancer
We describe melphalan pharmacokinetics in 26 patients treated by isolated limb perfusion (ILP). Group A (n = 11) were treated with a bolus of melphalan (1.5 mg kg-1), and in a phase I study the dose was increased to 1.75 mg kg-1. The higher dose was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e77bbfb558e4d82880f3d01450210a8
http://europepmc.org/articles/PMC1977921
http://europepmc.org/articles/PMC1977921
Autor:
J. A. Goldberg, Lynda Pettit, David J. Kerr, Colin S. McArdle, Tetsuro Kato, Tony L. Whately, Robert Blackie
Publikováno v:
Cancer. 67:952-955
Microencapsulated mitomycin C has been used for the treatment of intrahepatic tumors in Japan, but there have been no reports of its use in western countries. In this study, the pharmacokinetic profile of intrahepatic arterial mitomycin C microcapsul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e8712611fe74c16b4a69f2001d6c71
https://doi.org/10.1002/1097-0142(19910215)67:4<952::aid-cncr2820670416>3.0.co
https://doi.org/10.1002/1097-0142(19910215)67:4<952::aid-cncr2820670416>3.0.co
Autor:
K. A. Mannix, Al Harris, David J. Kerr, Robert Blackie, H. L. Elford, B. M. J. Cantwell, S. B. Kaye, J. Carmichael, D. Veale
Publikováno v:
Scopus-Elsevier
Twelve patients were treated with didox, a new ribonucleotide reductase inhibitor, by 36 h infusion. The maximum tolerated dose was 6 g m-2, above which dose-limiting hepatic toxicity was observed. Patient tolerance was significantly better using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01d89b5ab95e7125ba28fc179137e96
https://doi.org/10.1038/bjc.1990.98
https://doi.org/10.1038/bjc.1990.98
Autor:
Elaine M. Rankin, Nora Lawson, Robert Blackie, D. R. Newell, David J. Kerr, Stan B. Kaye, B. O'Neil, J. Cox, Craig Lewis, F. Boxall
Publikováno v:
Hematological oncology. 8(1)
Previous studies have demonstrated that there are circadian rhythms in susceptibility to a range of commonly used cytotoxic drugs. In this study we have compared the pharmacokinetics and myelotoxicity of carboplatin administered at 18.00 and 06.00 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2d5dc9a949717c7bf8551819b164a
https://pubmed.ncbi.nlm.nih.gov/2404843
https://pubmed.ncbi.nlm.nih.gov/2404843
Autor:
J. Amarin, S. B. Kaye, M. Harding, David J. Kerr, S. J. Harland, J. G. Farmer, Robert Blackie
Publikováno v:
Medical Oncology and Tumor Pharmacotherapy. 5:153-158
CHIP is a quadrivalent platinum (Pt) complex, introduced clinically as a less toxic alternative to cis-platinum. The drug's major route of excretion is via the kidneys, and in this study the pharmacokinetics of unchanged CHIP, filterable Pt and total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11894bdacc9dd16b1e6ad2c7f03f2e9a
https://doi.org/10.1007/bf02986438
https://doi.org/10.1007/bf02986438
Autor:
Robert Blackie, D. Veale, Al Harris, Joseph C. Carmichael, B. M. J. Cantwell, S. B. Kaye, David J. Kerr, H. L. Elford
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the drug by slow i.v. injection. Thirty-four patients with unresponsive metastatic carcinoma received the drug. There were 13 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f65ae6c3c8af2fb60101a8068594ac
https://doi.org/10.1038/bjc.1988.164
https://doi.org/10.1038/bjc.1988.164
Autor:
Robert, Blackie
Publikováno v:
The Hospital and Health Review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8882d3472ffa953095d3a5ddb2a8f761
https://pubmed.ncbi.nlm.nih.gov/29418801
https://pubmed.ncbi.nlm.nih.gov/29418801
Publikováno v:
Biochemical Society Transactions. 5:1725-1726
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3715f09b342fa6e7645914287495a4
https://doi.org/10.1042/bst0051725
https://doi.org/10.1042/bst0051725