Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Robert BALLOTTI"'
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon-Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan-Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2262-2267 (2024)
Externí odkaz:
https://doaj.org/article/4674eb9ca9f241b4a3996ff03dc79709
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Autor:
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-18 (2023)
Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumor
Externí odkaz:
https://doaj.org/article/1a3e75bad0684eebb8afbad93d505cd9
Autor:
Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
Abstract Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies
Externí odkaz:
https://doaj.org/article/a109a58f73fa4ac585009c1946fc3fba
Autor:
Emilie Jaune, Elisa Cavazza, Cyril Ronco, Oleksandr Grytsai, Patricia Abbe, Nedra Tekaya, Marwa Zerhouni, Guillaume Beranger, Lisa Kaminski, Frédéric Bost, Maeva Gesson, Meri Tulic, Paul Hofman, Robert Ballotti, Thierry Passeron, Thomas Botton, Rachid Benhida, Stéphane Rocchi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and ce
Externí odkaz:
https://doaj.org/article/0dea28988f794e45baced1a544ab1909
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is limited by primary and acquired resistance. The molecular determinants of the resistance have been extensively studied, but these discoveries have no
Externí odkaz:
https://doaj.org/article/e356ec7b9fdf481db44e3867ff78144c
Autor:
Meri K. Tulic, Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maéva Gesson, Laura Sormani, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stéphane Rocchi, Thierry Passeron
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased pri
Externí odkaz:
https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb
Autor:
Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 350-360 (2019)
Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with
Externí odkaz:
https://doaj.org/article/8b808996bad94c3988c55a3d62a6bc68
Autor:
Nausicaa Malissen, Nicolas Macagno, Samuel Granjeaud, Clémence Granier, Vincent Moutardier, Caroline Gaudy-Marqueste, Nadia Habel, Marion Mandavit, Bernard Guillot, Christine Pasero, Eric Tartour, Robert Ballotti, Jean-Jacques Grob, Daniel Olive
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading antitumor immunity. Here, HVEM expression levels in melanoma metastases were analyzed by imm
Externí odkaz:
https://doaj.org/article/7f0ae0ada5804c119b6ab5340c5d044e
Autor:
Thomas Botton, Eric Talevich, Vivek Kumar Mishra, Tongwu Zhang, A. Hunter Shain, Céline Berquet, Alexander Gagnon, Robert L. Judson, Robert Ballotti, Antoni Ribas, Meenhard Herlyn, Stéphane Rocchi, Kevin M. Brown, Nicholas K. Hayward, Iwei Yeh, Boris C. Bastian
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 573-588.e7 (2019)
Summary: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected hete
Externí odkaz:
https://doaj.org/article/0cc277c61e1b4388ac070ad9ad16b2a2
Autor:
Nelly Durand, Méliné Simsir, Laurie Signetti, Fabien Labbal, Robert Ballotti, Isabelle Mus-Veteau
Publikováno v:
Molecules, Vol 26, Iss 7, p 1867 (2021)
We previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-HT receptor antagonist, inhibited the doxorubicin efflux activity of the Hedgehog receptor Ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferat
Externí odkaz:
https://doaj.org/article/a5f7532d31c74354b267061628678f92