Adaptation of thermophilic enzymes from an ancestral reductive TCA cycle for carbon fixation in plants

Autor: Robert B. Rose, Greg Buhrman, Hayden Baer

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::476c5638dac8359c7a8cba1887bf9dc9
https://doi.org/10.1096/fasebj.2022.36.s1.r5043

Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from

Autor: Greg, Buhrman, Paul, Enríquez, Lucas, Dillard, Hayden, Baer, Vivian, Truong, Amy M, Grunden, Robert B, Rose

Publikováno v: Biochemistry. 60(4)

2-Oxoglutarate carboxylase (OGC), a unique member of the biotin-dependent carboxylase family from the order Aquificales, captures dissolved CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d0aa3618b4baf1c1caa2689bf2536fb
https://pubmed.ncbi.nlm.nih.gov/33464881

Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation

Autor: Sara A. Lewis, Sheetal Shetty, Sean Gamble, Jennifer Heim, Ningning Zhao, Gideon Stitt, Matthew Pankratz, Tara Mangum, Iris Marku, Robert B. Rosenberg, Angus A. Wilfong, Michael C. Fahey, Sukhan Kim, Scott J. Myers, Brian Appavu, Michael C. Kruer

Publikováno v: Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-5 (2023)

Abstract Background Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral pal

Externí odkaz: https://doaj.org/article/5f38822c243b44708b9a5294b17175e5

Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold

Autor: Jianfei Zhao, Ajeet Mandal, Ishminder Mann, Charles Vinson, Jaya Prakash Golla, Syed Khund Sayeed, Robert B. Rose

Publikováno v: Biochemical and Biophysical Research Communications. 449:248-255

Three oxidative products of 5-methylcytosine (5mC) occur in mammalian genomes. We evaluated if these cytosine modifications in a CG dinucleotide altered DNA binding of four B-HLH homodimers and three heterodimers to the E-Box motif CGCAG|GTG. We exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d18b1acfb3b83a88a8a9be6f7819b6
https://doi.org/10.1016/j.bbrc.2014.05.018

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs

Autor: Thierry Olivry, Robert Goggs, Theresa O'Toole, Lorna J. Kennedy, Robert B. Rose, Natasha J. Olby, Greg Buhrman, Lhoucine Chdid, Steven G. Friedenberg, Julien Guillaumin, Kathryn M. Meurs

Publikováno v: Friedenberg, S G, Buhrman, G, Chdid, L, Olby, N J, Olivry, T, Guillaumin, J, O'Toole, T, Goggs, R, Kennedy, L J, Rose, R B & Meurs, K M 2016, ' Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs ', Immunogenetics, vol. 68, no. 3, pp. 205-17 . https://doi.org/10.1007/s00251-015-0894-6

Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323e8e2c6cbe3fcdc5f2c94bf29c08d3
https://doi.org/10.1007/s00251-015-0894-6