Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Robert B. Nelson"'
Autor:
Mario Merlini, Victoria A. Rafalski, Katerina Akassoglou, William W. Seeley, Maya Ellisman, T. Michael Gill, Lennart Mucke, Keshav S. Subramanian, Robert B. Nelson, Pamela E. Rios Coronado, Catriona Syme, Gayathri Muthukumar, Jae K. Ryu, Dimitrios Davalos
Publikováno v:
Neuron, vol 101, iss 6
Summary Cerebrovascular alterations are a key feature of Alzheimer’s disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccc739e5edd0e90f5544b3d17407177
https://pubmed.ncbi.nlm.nih.gov/30897363
https://pubmed.ncbi.nlm.nih.gov/30897363
Autor:
Lennart Mucke, Catherine Bedard, Samuel J. Pfaff, Suresh Poda, Michelle R. Arkin, Mark A. Petersen, Jae K. Ryu, Kim M. Baeten, Katerina Akassoglou, Anke Meyer-Franke, Stevin H. Zorn, Kristina Hanspers, Catriona Syme, K.K. Hallenbeck, Kenny K. H. Ang, Alexander R. Pico, Robert B. Nelson, Raymond A. Swanson, Ryan A. Adams, Jeffrey B. Stavenhagen, Shoana L. Sikorski, Scott S. Zamvil, Ioanna Plastira, Veena Menon, Michael R. Machado, Stephen B. Freedman, Lars Østergaard Pedersen, Hiroyuki Hakozaki, Sophia Bardehle, Victoria A. Rafalski, Mark H. Ellisman, Pamela E. Rios Coronado, Justin P. Chan, Dimitrios Davalos, Andrew S. Mendiola
Publikováno v:
Nature immunology, vol 19, iss 11
Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer's disease (AD). However, the mechanisms that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6af962de7a0dd3774e7f8fdc95dc383
https://pubmed.ncbi.nlm.nih.gov/30323342
https://pubmed.ncbi.nlm.nih.gov/30323342
Publikováno v:
Journal of Structural Engineering. 139:1352-1361
Shake-table response of a 33.6-m-long (110-ft-long), four-span, RC bridge model with a continuous posttensioned superstructure supported on three, two-column bents was studied under horizontal bidirectional coherent simulated earthquakes. The pier he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d9c1ffc90ea872e858cb26f42b0d93
https://doi.org/10.1061/(asce)st.1943-541x.0000790
https://doi.org/10.1061/(asce)st.1943-541x.0000790
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118
https://doi.org/10.1016/j.bmcl.2010.12.118
Autor:
Matthew J. Arduino, Arjun Srinivasan, Robert B. Nelson, Lillian Pontacolone, Carol Wood-Koob, Nancy Thayer, Nick Mamalis, Henry F. Edelhauser, Terri S. Forster, Thomas L. Beardsley, Preeta K. Kutty, Stanley J. Berke
Publikováno v:
Journal of Cataract and Refractive Surgery. 34:585-590
Purpose To present the findings of an outbreak of toxic anterior segment syndrome (TASS). Setting Six states, 7 ophthalmology surgical centers, United States. Methods Cases were identified through electronic communication networks and via reports to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3668692c1f01fb9a3e21a2e49ba63af5
https://doi.org/10.1016/j.jcrs.2007.11.037
https://doi.org/10.1016/j.jcrs.2007.11.037
Autor:
Robert B. Nelson
Publikováno v:
Current Pharmaceutical Design. 11:3335-3352
There is extensive evidence that changes in immune system activation accompany the pathological changes of Alzheimer's disease (AD), but a mechanistic understanding of how the immune system actually participates in disease pathogenesis is still large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f1047b7869998a501d1f647df70fc0
https://doi.org/10.2174/138161205774370843
https://doi.org/10.2174/138161205774370843
Autor:
Robert B. Nelson, Susan E. Drozda, Steve Faraci, Kim Verdries, Pat Seymour, Robert A. Volkmann, Weimin Qian, and Anabella Villalobos, Dane R. Liston, W. Frost White, Charles E. Nolan, John A. Lowe, Michael Majchrzak, Deane M. Nason, Karen M. Ward
Publikováno v:
Journal of Medicinal Chemistry. 47:1575-1586
The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8883048ff2f6eb5be3dd0789c9cf1e
https://doi.org/10.1021/jm030519g
https://doi.org/10.1021/jm030519g
Autor:
John E. Burkhardt, Michael K. Ahlijanian, Robert D. Williams, Anthony Carlo, Robert B. Nelson, Nestor X. Barrezueta, Timothy M. Coskran, Amy Jakowski, Sheryl A. McCarthy, John D. McNeish, Kim P. Kowsz, Patricia A. Seymour
Publikováno v:
Proceedings of the National Academy of Sciences. 97:2910-2915
Hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in several neurodegenerative diseases including Alzheimer's disease. One potential mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c5f5681d655fa0cb591332ccb27ba9
https://doi.org/10.1073/pnas.040577797
https://doi.org/10.1073/pnas.040577797
Autor:
Kimberly A. Verdries, Martin Sanders, Michelle Vanase, Peter John Whittle, Jolanta Nowakowski, W. Stephen Faraci, Shawn D. Doran, Mark H. Stefaniak, James Baxter, Dane R. Liston, Robert B. Nelson, Steven D. Heck, Stevin H. Zorn, Michael A. Ashton, Charles E. Nolan, Robert A. Volkmann, Weimin Qian, John A. Lowe, Karen M. Ward, Celeste Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2569-2572
The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57b946192c2fe3b394f0a5498cb73f
https://doi.org/10.1016/s0960-894x(99)00432-1
https://doi.org/10.1016/s0960-894x(99)00432-1
Publikováno v:
Journal of Leadership Studies. 1:21-36
The May 1994 American Society of Training and Development (ASTD) meeting will be the 25th anniversary of Situational Leadership. This article by one of the original developers of that model and two of his colleagues reviews work that led to the model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa2d53462688a3fc3a0b1bdd0cb0323
https://doi.org/10.1177/107179199300100104
https://doi.org/10.1177/107179199300100104