Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Robert B. Hamanaka"'
Autor:
Rengul Cetin-Atalay, Angelo Y. Meliton, Kaitlyn A. Sun, Mariel E. Glass, Parker S. Woods, Ying-Jie Peng, Yun Fang, Robert B. Hamanaka, Nanduri R. Prabhakar, Gökhan M. Mutlu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease. While intermittent hypoxia (IH) and catecholamine release play an important role in this increased risk, the mechanisms are incompletely understood. We h
Externí odkaz:
https://doaj.org/article/78a6903cbc554691bb1bab10ab7d2575
Autor:
Rengul Cetin-Atalay, Angelo Y. Meliton, David Wu, Parker S. Woods, Kaitlyn A. Sun, Ying-Jie Peng, Jayasri Nanduri, Xiaoyu Su, Yun Fang, Robert B. Hamanaka, Nanduri Prabhakar, Gökhan M. Mutlu
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Obstructive sleep apnea (OSA) is a common breathing disorder affecting a significant percentage of the adult population. OSA is an independent risk factor for cardiovascular disease (CVD); however, the underlying mechanisms are not completely underst
Externí odkaz:
https://doaj.org/article/b9c692b18c724b9f9e6edc007e2175e8
Autor:
Robert B. Hamanaka, Gökhan M. Mutlu
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consist
Externí odkaz:
https://doaj.org/article/5ce31a5644ee4c99ab81d441b6baf8d6
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 451-459 (2016)
Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is nec
Externí odkaz:
https://doaj.org/article/d991e3c505c340fd92157ca6287bc356
Autor:
Parker S Woods, Lucas M Kimmig, Kaitlyn A Sun, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Rengül Cetin-Atalay, Willard W Sharp, Robert B Hamanaka, Gökhan M Mutlu
Publikováno v:
eLife, Vol 11 (2022)
Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit a unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived ma
Externí odkaz:
https://doaj.org/article/d5818448d3ea42e3ae690e6771139402
Autor:
Kaitlyn A Sun, Yan Li, Angelo Y Meliton, Parker S Woods, Lucas M Kimmig, Rengül Cetin-Atalay, Robert B Hamanaka, Gökhan M Mutlu
Publikováno v:
eLife, Vol 9 (2020)
Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood. RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of the top genes
Externí odkaz:
https://doaj.org/article/3d6a09096ba941b39c10203b4a2f095d
Autor:
David Wu, Ru-Ting Huang, Robert B Hamanaka, Matt Krause, Myung-Jin Oh, Cheng-Hsiang Kuo, Recep Nigdelioglu, Angelo Y Meliton, Leah Witt, Guohao Dai, Mete Civelek, Nanduri R Prabhakar, Yun Fang, Gökhan M Mutlu
Publikováno v:
eLife, Vol 6 (2017)
Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC meta
Externí odkaz:
https://doaj.org/article/a422b41b8bf842d3b7a599feb4f45e11
Autor:
Parker S Woods, Lucas M Kimmig, Kaitlyn A Sun, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Rengül Cetin-Atalay, Willard W Sharp, Robert B Hamanaka, Gökhan M Mutlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de4d3594c272404e130608dc204cdad
https://doi.org/10.7554/elife.77457.sa2
https://doi.org/10.7554/elife.77457.sa2
Autor:
Rengul Cetin‐Atalay, Angelo Y. Meliton, Kaitlyn A. Sun, Parker S. Woods, Ying‐Jie Peng, Yun Fang, Robert B. Hamanaka, Nanduri R. Prabhakar, Gokhan M. Mutlu
Publikováno v:
The FASEB Journal. 36
Autor:
Robert B. Hamanaka, Gökhan M. Mutlu
Publikováno v:
FEBS J
Fibrosis is a pathologic condition characterized by excessive deposition of extracellular matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated with significant morbidity and mortality, contributing to as many as