Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Robert B. Dubridge"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101205- (2022)
CRISPR/Cas9 gene-editing technology allows researchers to study protein function by specifically introducing double-stranded breaks in the gene of interest then analyze its subsequent loss in sensitive biological assays. To help characterize one of a
Externí odkaz:
https://doaj.org/article/df1a8ebe5ff44781a555a322c6d90a16
Autor:
Anand Panchal, Pui Seto, Russell Wall, Brian J. Hillier, Ying Zhu, Jessica Krakow, Aakash Datt, Elizabeth Pongo, Andisheh Bagheri, Tseng-Hui T. Chen, Jeremiah D. Degenhardt, Patricia A. Culp, Danielle E. Dettling, Maia V. Vinogradova, Chad May, Robert B. DuBridge
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Conditionally active COBRA™ (COnditional Bispecific Redirected Activation) T cell engagers are engineered to overcome the limitations of inherently active first-generation T cell engagers, which are unable to discern between tumor and healthy tissu
Externí odkaz:
https://doaj.org/article/f2605ce7f19c42fe8f1f08cf99498254
Autor:
Lemon Bryan D, Manasi Barath, Che-Leung Law, Robert B. Dubridge, Kenneth Sexton, Richard J. Austin, Stephen Yu, Timothy Yu, Purbasa Patnaik, Patrick A. Baeuerle, A. Jones, Anand Panchal, Luke Evnin, Russell Wall, Patricia Culp, Kathryn L. Strobel, Pui Seto, Vanitha Ramakrishnan, Holger Wesche, Wade Aaron, Sony Rocha
Publikováno v:
Molecular Cancer Therapeutics. 20:109-120
T cells have a unique capability to eliminate cancer cells and fight malignancies. Cancer cells have adopted multiple immune evasion mechanisms aimed at inhibiting T cells. Dramatically improved patient outcomes have been achieved with therapies gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7405941cbbfa5d733a65e82cb28cafa8
https://doi.org/10.1158/1535-7163.mct-20-0061
https://doi.org/10.1158/1535-7163.mct-20-0061
Autor:
Danielle E Dettling, Eilene Kwok, Lucy Quach, Aakash Datt, Jeremiah D Degenhardt, Anand Panchal, Pui Seto, Jessica L Krakow, Russell Wall, Brian J Hillier, Ying Zhu, Maia Vinogradova, Robert B DuBridge, Chad May
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004336
BackgroundDespite clinical success with T cell engagers (TCEs) targeting hematological malignancies, achieving a safe and efficacious dose in patients with solid tumors remains challenging. Due to potency, low levels of target antigen expression on n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6442899ddb12569f97e7248a2000f18
https://doi.org/10.1136/jitc-2021-004336
https://doi.org/10.1136/jitc-2021-004336
Autor:
Maia Vinogradova, Danielle E. Dettling, Russell Wall, Jessica L. Krakow, Aakash Datt, Elizabeth Pongo, Tseng-Hui T Chen, Andisheh Bagheri, Brian J. Hillier, Patricia Culp, Ying Zhu, Chad May, Robert B. Dubridge, Jeremiah D. Degenhardt, Pui Seto, Anand Panchal
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Conditionally active COBRA™ (COnditional Bispecific Redirected Activation) T cell engagers are engineered to overcome the limitations of inherently active first-generation T cell engagers, which are unable to discern between tumor and healthy tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2fd557a45866fee279d7f92d7371bd
https://doi.org/10.1080/19420862.2020.1792130
https://doi.org/10.1080/19420862.2020.1792130
Autor:
Ying Zhu, Lucy Quach, Robert B. Dubridge, Maia Vinogradova, Jeremiah D. Degenhardt, Anand Panchal, Chad May, Danielle E. Dettling, Pui Seto, Aakash Datt, Russell Wall, Jessica L. Krakow, Brian J. Hillier, Eilene Kwok
Publikováno v:
Cancer Research. 79:557-557
Despite clinical success with bispecific antibodies (bsAbs) targeting hematological malignancies (e.g. blinatumomab, a CD19xCD3 bsAb), efficacy in solid tumor indications remains a significant challenge. Because T cell redirecting bsAbs are so potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1885b3fdcd6cc3f0cc50b52c7c2527cf
https://doi.org/10.1158/1538-7445.am2019-557
https://doi.org/10.1158/1538-7445.am2019-557
Autor:
Zhiyuan Ma, Jennifer Razo, Robert B. Dubridge, Dixie Polakoff, David B. Powers, Keith T. Wilson, Charles M. Forsyth, Alexander V. Ivanov, Veronica Juan, Yoshiko Akamatsu, Minhtam Doan
Publikováno v:
mAbs
We developed a method for deep mutational scanning of antibody complementarity-determining regions (CDRs) that can determine in parallel the effect of every possible single amino acid CDR substitution on antigen binding. The method uses libraries of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a966f62df2b555bb1cd9a9a01ed891
https://doi.org/10.4161/mabs.24979
https://doi.org/10.4161/mabs.24979
Autor:
David B. Powers, Robert B. Dubridge, Zhenghai Xu, Zhiyuan Ma, Keith T. Wilson, Dixie Polakoff, Veronica Juan, Yoshiko Akamatsu, Alexander V. Ivanov
Publikováno v:
The Journal of Immunology. 189:4470-4477
CTLA4-Ig is an Fc fusion protein containing the extracellular domain of CTLA-4, a receptor known to deliver a negative signal to T cells. CTLA4-Ig modulates T cell costimulatory signals by blocking the CD80 and CD86 ligands from binding to CD28, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdaa7a84077f5a1728f05d7d7c91ca3
https://doi.org/10.4049/jimmunol.1201813
https://doi.org/10.4049/jimmunol.1201813
Publikováno v:
mAbs. 2:256-265
Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for their targets, convey effector functions and enjoy robust manufacturing procedures. Humanization of murine monoclonal antibodies has vastly improved their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b480a78129202413a2cab7937013cd4f
https://doi.org/10.4161/mabs.2.3.11641
https://doi.org/10.4161/mabs.2.3.11641
Autor:
David H. Lloyd, Kevin Corcoran, George Stefan Golda, Michael F. Foy, James W. Kirchner, Rithy Roth, Sydney Brenner, Sarah N. McCurdy, Dave George, Robert B. Dubridge, Sam Eletr, Mark Ewan, Steven Williams, Maria Johnson, Eric Vermaas, John Bridgham, Michael C. Pallas, Timothy Burcham, Karen L. Fearon, Keith Moon, Davida Johnson, Glenn Albrecht, Shujun Luo, Jen-I Mao
Publikováno v:
Nature Biotechnology. 18:630-634
We describe a novel sequencing approach that combines non-gel-based signature sequencing with in vitro cloning of millions of templates on separate 5 microm diameter microbeads. After constructing a microbead library of DNA templates by in vitro clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42a800f1374a578bc3567c890336d2
https://doi.org/10.1038/76469
https://doi.org/10.1038/76469