Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert B. Crochet"'
Publikováno v:
Free Radical Biology and Medicine. 102:240-247
MitoNEET, a primary target of type II diabetes drug pioglitazone, has an essential role in regulating energy metabolism, iron homeostasis, and production of reactive oxygen species in mitochondria. Structurally, mitoNEET is anchored to the mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f2340ccdb8a92ad57eafdcb3223f5b
https://doi.org/10.1016/j.freeradbiomed.2016.12.001
https://doi.org/10.1016/j.freeradbiomed.2016.12.001
Autor:
Song-Gun Kim, Yong Hwan Lee, Herie Lee, David B. Neau, Robert B. Crochet, Young Sun Yim, Jeong Do Kim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 85:117-124
The heart-specific isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) is an important regulator of glycolytic flux in cardiac cells. Here, we present the crystal structures of two PFKFB2 orthologues, human and bovine, at resolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f898c21b63933af2360d7528d17e796
https://doi.org/10.1002/prot.25204
https://doi.org/10.1002/prot.25204
Autor:
Anne Grove, Dinesh K Deochand, Robert B. Crochet, Inoka C. Perera, Nathaniel C. Gilbert, Marcia E. Newcomer
Publikováno v:
Molecular BioSystems. 12:2417-2426
Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels of urate and triggers production or release of urate oxidase. The transcription factor i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6bc900030d595377b5e686f203dcdf
https://doi.org/10.1039/c6mb00304d
https://doi.org/10.1039/c6mb00304d
Autor:
Robert B, Crochet, Jeong-Do, Kim, Herie, Lee, Young-Sun, Yim, Song-Gun, Kim, David, Neau, Yong-Hwan, Lee
Publikováno v:
Proteins. 85(1)
The heart-specific isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) is an important regulator of glycolytic flux in cardiac cells. Here, we present the crystal structures of two PFKFB2 orthologues, human and bovine, at resolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14a5a5150d5305164e4050f30ff66240
https://pubmed.ncbi.nlm.nih.gov/27802586
https://pubmed.ncbi.nlm.nih.gov/27802586
Autor:
Minsuh Seo, Yong Hwan Lee, Michael C. Cavalier, Robert B. Crochet, Seung-Jong Park, Young Sun Yim, Jeong Do Kim
Publikováno v:
Analytical Biochemistry. 418:143-148
Efforts toward improving the predictiveness in tier-based approaches to virtual screening (VS) have mainly focused on protein kinases. Despite their significance as drug targets, small molecule kinases have been rarely tested with these approaches. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74324485529e31a8126f3a2d2a634919
https://doi.org/10.1016/j.ab.2011.06.035
https://doi.org/10.1016/j.ab.2011.06.035
Autor:
Yong Hwan Lee, Jong S. Rim, Ru Gao, Robert B. Crochet, Jaroslaw Staszkiewicz, Kenneth J. Eilertsen, Jeong‐Do Kim
Publikováno v:
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a402d95044ee603e4d2ea90f51c2026
https://doi.org/10.1002/9781118695746.ch10
https://doi.org/10.1002/9781118695746.ch10
Since the first theorization of the Warburg effect as a metabolic characteristic of cancer, a great deal of progress has been made in the understanding of molecular details underlying the metabolic alterations that cancer cells evolved for survival a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483aae825017c371a4c9fe87fca4a66d
https://doi.org/10.1016/b978-0-12-396521-9.00014-0
https://doi.org/10.1016/b978-0-12-396521-9.00014-0