Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration

Autor: David C. Lyon, Georgina A. Lean, Magdalene J. Seiler, Andrzej T. Foik, Bryce T McLelland, Robert B. Aramant, Leo R. Scholl, Anuradha Mathur

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 38, iss 50
Frontiers in Neuroscience

To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed. In rodent studies, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d690ffe7abaf8623d893c60d01221037
https://doi.org/10.1523/jneurosci.1279-18.2018

Human Embryonic Retinal Cell Transplants in Athymic Immunodeficient Rat Hosts

Autor: Robert B. Aramant, Magdalene J. Seiler

Publikováno v: Cell Transplantation, Vol 3 (1994)

This study investigates the possibility to use the athymic “nude” rat as a host for the transplantation of human embryonic retinal cells without immunosuppression. The long-term development of such transplants is compared with results from our ea

Externí odkaz: https://doaj.org/article/4ac160a49eea480998b5fc2506e68a96

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

Autor: Anuradha Mathur, Bryce T McLelland, Hans S. Keirstead, Gabriel Nistor, Bin Lin, Magdalene J. Seiler, Biju B. Thomas, Robert B. Aramant

Publikováno v: Investigative ophthalmology & visual science, vol 59, iss 6
Investigative Ophthalmology & Visual Science
McLelland, BT; Lin, B; Mathur, A; Aramant, RB; Thomas, BB; Nistor, G; et al.(2018). Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(6), 2586-2603. doi: 10.1167/iovs.17-23646. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/00r7j811

Author(s): McLelland, Bryce T; Lin, Bin; Mathur, Anuradha; Aramant, Robert B; Thomas, Biju B; Nistor, Gabriel; Keirstead, Hans S; Seiler, Magdalene J | Abstract: Purpose:To investigate whether sheets of retina organoids derived from human embryonic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4637d49c1ac5e9c6bbd0d3b0cdd39e
https://escholarship.org/uc/item/00r7j811

In vitro isolation and expansion of human retinal progenitor cells

Autor: Scott R. Whittemore, Peng Yang, Magdalene J. Seiler, Robert B. Aramant

Publikováno v: Yang, P; Seiler, MJ; Aramant, RB; & Whittemore, SR. (2016). In vitro isolation and expansion of human retinal progenitor cells.. Experimental Neurology. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8vt0620m
Experimental neurology, vol 177, iss 1

Human retinal development proceeds with temporal and spatial precision. Although differentiation starts around the beginning of the third month of gestation, the majority of cells in the outer neuroblastic layer of human neural retina are still proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19889cf17bb8c455f58f5ccad7bc1695
http://www.escholarship.org/uc/item/8vt0620m

Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration

Autor: Magdalene J. Seiler, Robert B. Aramant, Mathias W. Seeliger, Kristina Narfström, Melissa J. Mahoney, Ragnheidur Bragadottir

Publikováno v: Veterinary Ophthalmology. 12:158-169

Purpose To investigate whether sheets of fetal retinal allografts can integrate into the dystrophic Abyssinian cat retina with progressive rod cone degeneration. Methods Fetal retinal sheets (cat gestational day 42), incubated with BDNF microspheres,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dd6b3aae29d308bd37056a7a19d081
https://doi.org/10.1111/j.1463-5224.2009.00693.x