Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Robert B. Sim"'
Autor:
Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Robert B. Sim
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. How
Externí odkaz:
https://doaj.org/article/eaef8149bb46499e8a5a01fdce376f2a
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Autor:
Nazar Beirag, Praveen M. Varghese, Martin Mayora Neto, Ahmad Al Aiyan, Haseeb A. Khan, Moneeb Qablan, Mohamed H. Shamji, Robert B. Sim, Nigel Temperton, Uday Kishore
Publikováno v:
Viruses, Vol 15, Iss 6, p 1269 (2023)
The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection. However, there is
Externí odkaz:
https://doaj.org/article/98cc6f76dc6e4bdd8e9b27ee26553a0c
Autor:
Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that le
Externí odkaz:
https://doaj.org/article/b389acf03e7945558cd931b8c8ff9fed
Autor:
Praveen M. Varghese, Valarmathy Murugaiah, Nazar Beirag, Nigel Temperton, Haseeb A. Khan, Salman H. Alrokayan, Mohammed N. Al-Ahdal, Beatrice Nal, Futwan A. Al-Mohanna, Robert B. Sim, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions
Externí odkaz:
https://doaj.org/article/6244d0b5bb80483e8c4651b6363063f7
Autor:
Valarmathy Murugaiah, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface.
Externí odkaz:
https://doaj.org/article/0a82a81391d645008c3a4433be53c3e5
Autor:
Eleni‐Pavlina Karagianni, Evanthia Kontomina, Edward D. Lowe, Konstantinos Athanasopoulos, Georgia Papanikolaou, Vasiliki Garefalaki, Varvara Kotseli, Sofia Zaliou, Tom Grimaud, Konstantina Arvaniti, Maria‐Aggeliki Tsatiri, Giannoulis Fakis, Anthony E. Glenn, Pietro Roversi, Areej Abuhammad, Ali Ryan, Robert B. Sim, Edith Sim, Sotiria Boukouvala
Publikováno v:
The FEBS Journal. 290:2412-2436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c327436a463fa5a3b5a06d338e13d869
https://doi.org/10.1111/febs.16642
https://doi.org/10.1111/febs.16642
Autor:
Arshad Mehmood, Lubna Kouser, Anuvinder Kaur, Uffe Holmskov, Mohammed N. Al-Ahdal, Robert B. Sim, Uday Kishore, Anthony G. Tsolaki
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Bovine conglutinin, the first animal collectin to be discovered, is structurally very similar to Surfactant Protein D (SP-D). SP-D is known to interact with Mycobacterium tuberculosis, and the closely-related M. bovis, the causative agent of bovine t
Externí odkaz:
https://doaj.org/article/33e9193b05084cb6bc855a1cbc4349fa
Autor:
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore
Publikováno v:
Viruses, Vol 13, Iss 5, p 824 (2021)
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators. Its principal function is to eliminate pathogens via activation of three distinct pathway
Externí odkaz:
https://doaj.org/article/5e232fd0b548449ab0810e7652ad0552
Publikováno v:
Mayilyan, K R, Krarup, A, Soghoyan, A F, Jensenius, J C & Sim, R B 2023, ' L-ficolin-MASP arm of the complement system in schizophrenia ', Immunobiology, vol. 228, no. 2, 152349 . https://doi.org/10.1016/j.imbio.2023.152349
The abnormal neurodevelopment secondary to in utero adversities, such as hypoxia, malnutrition and maternal infections, underlies schizophrenia (SZ) etiology. As the genes of MBL-associated serine proteases (MASP) of the complement lectin pathway, MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48c59185bf840986bbcfef41db03c64
https://pure.au.dk/portal/da/publications/lficolinmasp-arm-of-the-complement-system-in-schizophrenia(130a7e7a-4017-401c-9753-692097b772e2).html
https://pure.au.dk/portal/da/publications/lficolinmasp-arm-of-the-complement-system-in-schizophrenia(130a7e7a-4017-401c-9753-692097b772e2).html
Autor:
Maha Ahmed Al-Mozaini, Anthony G. Tsolaki, Munirah Abdul-Aziz, Suhair M. Abozaid, Mohammed N. Al-Ahdal, Ansar A. Pathan, Valarmathy Murugaiah, Evgeny M. Makarov, Anuvinder Kaur, Robert B. Sim, Uday Kishore, Lubna Kouser
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously
Externí odkaz:
https://doaj.org/article/36f7c38f819b4a6fbc5908bb3d060aa6