Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Robert B Peery"'
Autor:
Jonathan A Lee, Paul Shinn, Susan Jaken, Sarah Oliver, Francis S Willard, Steven Heidler, Robert B Peery, Jennifer Oler, Shaoyou Chu, Noel Southall, Thomas S Dexheimer, Jeffrey Smallwood, Ruili Huang, Rajarshi Guha, Ajit Jadhav, Karen Cox, Christopher P Austin, Anton Simeonov, G Sitta Sittampalam, Saba Husain, Natalie Franklin, David J Wild, Jeremy J Yang, Jeffrey J Sutherland, Craig J Thomas
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130796 (2015)
Phenotypic assays have a proven track record for generating leads that become first-in-class therapies. Whole cell assays that inform on a phenotype or mechanism also possess great potential in drug repositioning studies by illuminating new activitie
Externí odkaz:
https://doaj.org/article/1946423edacf41cd981806581d41073c
Publikováno v:
Biotechnology Progress. 32:1301-1307
Chinese hamster ovary (CHO) cells remain the default production host for many biopharmaceutical drugs, particularly monoclonal antibodies (mAb). Production of gram and kilogram quantities of protein typically requires the generation of stable CHO clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7562b99c55dc026b1959092d2b405b55
https://doi.org/10.1002/btpr.2307
https://doi.org/10.1002/btpr.2307
Autor:
Dawn L. Norris, Yashas Rajendra, Sowmya Balasubramanian, Gavin C. Barnard, James R. Swartling, Neil A. McCracken, Robert B. Peery, Christopher C. Frye
Publikováno v:
Biotechnology progress. 33(2)
Chinese hamster ovary (CHO) cells remain the most popular host for the production of biopharmaceutical drugs, particularly monoclonal antibodies (mAbs), bispecific antibodies, and Fc-fusion proteins. Creating and characterizing the stable CHO clonall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb07772879d3fce2baacf38d0e470dba
https://pubmed.ncbi.nlm.nih.gov/28188692
https://pubmed.ncbi.nlm.nih.gov/28188692
Autor:
Michael Bacica, Stephen Demarest, Gavin C. Barnard, Yashas Rajendra, Robert B. Peery, Xiufeng Wu, J.R. Fitchett, Maria D. Hougland
Publikováno v:
Biotechnology progress. 33(2)
IgG bispecific antibodies (BsAbs) represent one of the preferred formats for bispecific antibody therapeutics due to their native-like IgG properties and their monovalent binding to each target. Most reported studies utilized transient expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4662f4873c22045ca6cdfd9f111f2
https://pubmed.ncbi.nlm.nih.gov/27977915
https://pubmed.ncbi.nlm.nih.gov/27977915
Publikováno v:
Biotechnology progress. 32(5)
Chinese hamster ovary (CHO) cells remain the default production host for many biopharmaceutical drugs, particularly monoclonal antibodies (mAb). Production of gram and kilogram quantities of protein typically requires the generation of stable CHO clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4aa75c234a7ccc56b786ee2b27d0fb6
https://pubmed.ncbi.nlm.nih.gov/27254818
https://pubmed.ncbi.nlm.nih.gov/27254818
Autor:
Francis S. Willard, Jonathan A. Lee, Christopher M. Moxham, Tamika D. Meredith, Robert B. Peery, Karen Leigh Cox, Sarah E. Oliver, Jennifer Oler, Steven A. Heidler, Rachelle J. Sells Galvin, Wendy H. Gough, Alan David Palkowitz, Shaoyou Chu, Saba Husain
Publikováno v:
SLAS Discovery. 16:588-602
Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265c06651bbb3fcdfa65d1c83fae79d
https://doi.org/10.1177/1087057111405379
https://doi.org/10.1177/1087057111405379
Autor:
Bruce W. Konicek, Jennifer R. Stephens, Nathaniel Robichaud, Ann M. McNulty, Karen E. Ellis, Denis J. McCann, Philip W. Iversen, Michele Dowless, Louis Stancato, Chad A. Dumstorf, Robert B. Peery, Nahum Sonenberg, Jeremy R. Graff, Stephen Parsons, Jerry Pelletier, Luc Furic, Jonathan M. Yingling
Publikováno v:
Cancer Research. 71:1849-1857
Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation and metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by phosphorylating the inhibitory 4E binding proteins (4E-BP). This liberates eIF4E an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fee644c1bcee194c081d2f095e7e340
https://doi.org/10.1158/0008-5472.can-10-3298
https://doi.org/10.1158/0008-5472.can-10-3298
Autor:
Sowmya Balasubramanian, Maggie Lee, Regina N. White, Ronan M. Kelly, Gavin C. Barnard, Robert B. Peery, Jeremy Minshull
Publikováno v:
Biotechnology Journal. 13:1700748
Clonally derived cell lines (CDCL) from Chinese Hamster Ovary (CHO) host cell lines, remain the most popular method to manufacture therapeutic proteins. However, CHO cell pools are increasingly being used as an alternate method to produce therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84827a611b1a49a61a64afa86b319bc5
https://doi.org/10.1002/biot.201700748
https://doi.org/10.1002/biot.201700748
Autor:
Francis S. Willard, Steven A. Heidler, Jonathan A. Lee, G. Sitta Sittampalam, Robert B. Peery, Ajit Jadhav, Saba Husain, Sarah E. Oliver, Jeremy J. Yang, Noel Southall, Shaoyou Chu, Thomas S. Dexheimer, David J. Wild, Paul Shinn, Christopher P. Austin, Craig J. Thomas, Natalie Franklin, Jennifer Oler, Anton Simeonov, Jeffrey K. Smallwood, Susan Jaken, Ruili Huang, Rajarshi Guha, Karen Cox, Jeffrey J. Sutherland
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130796 (2015)
PLoS ONE
PLoS ONE
Phenotypic assays have a proven track record for generating leads that become first-in-class therapies. Whole cell assays that inform on a phenotype or mechanism also possess great potential in drug repositioning studies by illuminating new activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bef9afbfef400dbca451e7fa2adced8
http://europepmc.org/articles/PMC4503722?pdf=render
http://europepmc.org/articles/PMC4503722?pdf=render
Publikováno v:
Journal of Biological Chemistry. 275:30864-30872
Acyl carrier protein synthase (AcpS) is an essential enzyme in the biosynthesis of fatty acids in all bacteria. AcpS catalyzes the transfer of 4'-phosphopantetheine from coenzyme A (CoA) to apo-ACP, thus converting apo-ACP to holo-ACP that serves as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ed3c2d801ba132ce2ecb607be5db9a
https://doi.org/10.1074/jbc.m004475200
https://doi.org/10.1074/jbc.m004475200