Evaluating the clinical impact of a genomic classifier in prostate cancer using individualized decision analysis.

Autor: Jennifer Mason Lobo, Adam P Dicker, Christine Buerki, Elai Daviconi, R Jeffrey Karnes, Robert B Jenkins, Nirav Patel, Robert B Den, Timothy N Showalter

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0116866 (2015)

BackgroundCurrently there is controversy surrounding the optimal way to treat patients with prostate cancer in the post-prostatectomy setting. Adjuvant therapies carry possible benefits of improved curative results, but there is uncertainty in which

Externí odkaz: https://doaj.org/article/fe33227739274e62a74eeef941937665

Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

Autor: Lisa A Boardman, Ruth A Johnson, Kimberly B Viker, Kari A Hafner, Robert B Jenkins, Douglas L Riegert-Johnson, Thomas C Smyrk, Kristin Litzelman, Songwon Seo, Ronald E Gangnon, Corinne D Engelman, David N Rider, Russell J Vanderboom, Stephen N Thibodeau, Gloria M Petersen, Halcyon G Skinner

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80015 (2013)

IntroductionColorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed chromosomal instability (CIN) and excessively shortened telomeres. Up to 80% of CRC is microsatellite stable (MSS) and is historically considered to be chromo

Externí odkaz: https://doaj.org/article/0cbf7004f69043d4a6e8c2961198119c

A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain.

Autor: Gobinda Sarkar, Geoffry L Curran, Eric Mahlum, Teresa Decklever, Thomas M Wengenack, Anthony Blahnik, Bridget Hoesley, Val J Lowe, Joseph F Poduslo, Robert B Jenkins

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28881 (2011)

BACKGROUND: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically

Externí odkaz: https://doaj.org/article/d838b4f4789547e29fc90563cbf78dfb

The association between genetically elevated polyunsaturated fatty acids and risk of cancerResearch in context

Autor: Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin, Nathan Tintle, Terri Rice, Iona Cheng, Mark Jenkins, Steve Gallinger, Alex J. Cornish, Amit Sud, Jayaram Vijayakrishnan, Margaret Wrensch, Mattias Johansson, Aaron D. Norman, Alison Klein, Alyssa Clay-Gilmour, Andre Franke, Andres V. Ardisson Korat, Bill Wheeler, Björn Nilsson, Caren Smith, Chew-Kiat Heng, Ci Song, David Riadi, Elizabeth B. Claus, Eva Ellinghaus, Evgenia Ostroumova, Hosnijeh, Florent de Vathaire, Giovanni Cugliari, Giuseppe Matullo, Irene Oi-Lin Ng, Jeanette E. Passow, Jia Nee Foo, Jiali Han, Jianjun Liu, Jill Barnholtz-Sloan, Joellen M. Schildkraut, John Maris, Joseph L. Wiemels, Kari Hemminki, Keming Yang, Lambertus A. Kiemeney, Lang Wu, Laufey Amundadottir, Marc-Henri Stern, Marie-Christine Boutron, Mark Martin Iles, Mark P. Purdue, Martin Stanulla, Melissa Bondy, Mia Gaudet, Lenha Mobuchon, Nicola J. Camp, Pak Chung Sham, Pascal Guénel, Paul Brennan, Philip R. Taylor, Quinn Ostrom, Rachael Stolzenberg-Solomon, Rajkumar Dorajoo, Richard Houlston, Robert B. Jenkins, Sharon Diskin, Sonja I. Berndt, Spiridon Tsavachidis, Stephen J. Channock, Tabitha Harrison, Tessel Galesloot, Ulf Gyllensten, Vijai Joseph, Y. Shi, Wenjian Yang, Yi Lin, Stephen K. Van Den Eeden

Publikováno v: EBioMedicine, Vol 91, Iss , Pp 104510- (2023)

Summary: Background: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. Methods: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cance

Externí odkaz: https://doaj.org/article/89940d7363ce43c781ea8d5c3c0a79fa

8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

Autor: Jeanette E. Eckel-Passow, Huihuang Yan, Matthew L. Kosel, Daniel Serie, Paul A. Decker, Robert B. Jenkins, Brian Costello, Bradley Leibovich, Thai H. Ho, Alexander Parker

Publikováno v: BMC Urology, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with

Externí odkaz: https://doaj.org/article/7456cd0cc0074aa8b6550e1aa73a2659