Enzymes from fungal and plant origin required for chemical diversification of insecticidal loline alkaloids in grass-Epichloë symbiota.

Autor: Juan Pan, Minakshi Bhardwaj, Padmaja Nagabhyru, Robert B Grossman, Christopher L Schardl

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115590 (2014)

The lolines are a class of bioprotective alkaloids that are produced by Epichloë species, fungal endophytes of grasses. These alkaloids are saturated 1-aminopyrrolizidines with a C2 to C7 ether bridge, and are structurally differentiated by the vari

Externí odkaz: https://doaj.org/article/3c19139f6e3f486e9c9178171a1321a1

1,2-Diamination of Alkenes via 1,3-Dipolar Cycloaddition with Azidium Ions or Azides

Autor: Setareh Saryazdi, Sean Parkin, Robert B. Grossman

Publikováno v: Organic Letters. 25:331-335

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33667f5d6938313f17d4346c4580e597
https://doi.org/10.1021/acs.orglett.2c03908

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Autor: Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde

Publikováno v: ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)

Externí odkaz: https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087

Structural Revision of Garcinielliptin Oxide and Garcinielliptone E

Autor: Xing-Wei Yang, Robert B. Grossman

Publikováno v: Journal of Natural Products. 83:2041-2044

Previously, Lin et al. reported the isolation and structural determination of two triterpenoids, garcinielliptin oxide (GO) and garcinielliptone E (GE). Their unusual structural features, which remained unparalleled in subsequent decades despite the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22003a562514f72019666aa369a4f268
https://doi.org/10.1021/acs.jnatprod.0c00306

An unusually short intermolecular N—H...N hydrogen bond in crystals of the hemi-hydrochloride salt of 1-exo-acetamidopyrrolizidine

Autor: Qianxiang Ai, Robert B. Grossman, Sean Parkin, Minakshi Bhardwaj

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 1, Pp 77-81 (2020)

The title compound [systematic name: (1R*, 8S)-2-acetamidooctahydropyrrolizin-4-ium chloride–N-[(1R, 8S)-hexahydro-1H-pyrrolizin-2-yl)acetamide (1/1)], 2(C9H16N2O)·HCl or C9H17N2O+·Cl−·C9H16N2O, arose as an unexpected product when 1-exo-acetam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dba9d54ba76f0004ae92debfc675abe
http://scripts.iucr.org/cgi-bin/paper?S2056989019016517