Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Robert B Gilchrist"'
Autor:
Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, Lynn-Jee Kim, Amelia Brown, Angelique H Riepsamen, Safaa Cabot, Emily R Frost, Sonia Bustamante, Ling Zhong, Kaisa Selesniemi, Derek Wong, Romanthi Madawala, Maria Marchante, Dale M Goss, Catherine Li, Toshiyuki Araki, David J Livingston, Nigel Turner, David A Sinclair, Kirsty A Walters, Hayden A Homer, Robert B Gilchrist, Lindsay E Wu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2583-2618 (2024)
Abstract Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the r
Externí odkaz:
https://doaj.org/article/d790c5942525403bbb14e10daad41da9
Autor:
Valentina Rodriguez Paris, Xin Yi Denise Wong, Samantha M Solon-Biet, Melissa C Edwards, Ali Aflatounian, Robert B Gilchrist, Stephen J Simpson, David J Handelsman, Nadeem O Kaakoush, Kirsty A Walters
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiome has been implicated in polycystic ovary syndrome (PCOS) pathophysiology. PCOS is a disorder with reproductive, endocrine and metabolic irregularities, and several studies report that PCOS is associated with a decrease in microbial
Externí odkaz:
https://doaj.org/article/b8726557763444eca5d070104fa8422e
Autor:
Jaqueline Sudiman, Melanie L Sutton-McDowall, Lesley J Ritter, Melissa A White, David G Mottershead, Jeremy G Thompson, Robert B Gilchrist
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103563 (2014)
Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was
Externí odkaz:
https://doaj.org/article/664e9419a0a546c7a18be342b40ee979
Autor:
Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C. Edwards, Blake J. Cochran, William L. Ledger, Robert B. Gilchrist, Michael J. Bertoldo, Lindsay E. Wu, Kirsty A. Walters
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101583- (2022)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, defined by reproductive and endocrine abnormalities, with metabolic dysregulation including obesity, insulin resistance and hepatic steatosis. Recently, it was found that skeletal muscl
Externí odkaz:
https://doaj.org/article/7efa99fc15fb4a50a22ad24541ad7e8e
Autor:
Robert B. Gilchrist, Johan Smitz
Publikováno v:
Fertility and Sterility. 119:524-539
Oocyte in vitro maturation (IVM) is an assisted reproductive technology with a long and sometimes checked history. It is a minimally invasive technique involving the deliberate collection of immature oocytes from patients that have received no or min
Autor:
Aiat Shamsa, Robert B. Gilchrist, David M. Robertson, Rachael J. Rodgers, Mark W. Donoghoe, William L. Ledger, Jason A. Abbott, Angelique H. Riepsamen
Publikováno v:
Reproductive Sciences. 30:1521-1527
Abstract Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of o
Autor:
Michael J. Bertoldo, Dave R. Listijono, Wing-Hong Jonathan Ho, Angelique H. Riepsamen, Dale M. Goss, Dulama Richani, Xing L. Jin, Saabah Mahbub, Jared M. Campbell, Abbas Habibalahi, Wei-Guo Nicholas Loh, Neil A. Youngson, Jayanthi Maniam, Ashley S.A. Wong, Kaisa Selesniemi, Sonia Bustamante, Catherine Li, Yiqing Zhao, Maria B. Marinova, Lynn-Jee Kim, Laurin Lau, Rachael M. Wu, A. Stefanie Mikolaizak, Toshiyuki Araki, David G. Le Couteur, Nigel Turner, Margaret J. Morris, Kirsty A. Walters, Ewa Goldys, Christopher O’Neill, Robert B. Gilchrist, David A. Sinclair, Hayden A. Homer, Lindsay E. Wu
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1670-1681.e7 (2020)
Summary: Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of
Externí odkaz:
https://doaj.org/article/a90efaf77b4241cf832c48855e659c9a
Autor:
Nazli Akin, Dulama Richani, Xiuhua Liao, Yiqing Zhao, Anamaria-Cristina Herta, Katy Billooye, William A. Stocker, David G. Mottershead, Craig A. Harrison, Johan Smitz, Ellen Anckaert, Robert B. Gilchrist
Publikováno v:
J Assist Reprod Genet
PURPOSE: In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for certain patient grou
Autor:
Angelique H. Riepsamen, Mark W. Donoghoe, Inthrani R. Indran, Leah Hechtman, David M. Robertson, Robert B. Gilchrist, William L. Ledger, Eu‐Leong Yong
Publikováno v:
Clinical endocrinology.
Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are critical paracrine regulators of female fertility and are predominantly expressed by oocytes. However, it is unknown if serum concentrations reflect changes in ovari
Autor:
Dulama Richani, Robert B. Gilchrist
Publikováno v:
Biology of Reproduction. 106:243-252
Oocytes are maintained in a state of meiotic arrest following the first meiotic division until ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a process facilitated by the cyclic nucleotides cGMP and cAMP.