Zobrazeno 1 - 10 of 237 pro vyhledávání: '"Robert B Diasio"'
1
Akademický článek
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
Autor: Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer
Publikováno v: eLife, Vol 13 (2024)
Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanis
Externí odkaz: https://doaj.org/article/f486b24826a64551bd611deb78f24793
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2
Akademický článek
Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications
Autor: Karim ReFaey, MD, Shashwat Tripathi, BSA, Sanjeet S. Grewal, MD, Adip G. Bhargav, MD, David J. Quinones, Kaisorn L. Chaichana, MD, Samuel O. Antwi, PhD, Leslie T. Cooper, MD, Fredric B. Meyer, MD, Roxana S. Dronca, MD, Robert B. Diasio, MD, Alfredo Quinones-Hinojosa, MD
Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 3, Pp 645-653 (2021)
Objective: To highlight the current global trends in mortality for cardiovascular disease and cancer. Methods: The World Health Organization and the World Bank DataBank databases were used to analyze mortality rates for cancer and cardiovascular dise
Externí odkaz: https://doaj.org/article/f519c1eea8414299849367a25ddf8ef2
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3
Akademický článek
Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance
Autor: Zhiquan Wang, Rentian Wu, Qian Nie, Kelly J. Bouchonville, Robert B. Diasio, Steven M. Offer
Publikováno v: Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Externí odkaz: https://doaj.org/article/accd85a0450f4044aac0532324b3811d
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8
Data from ADAM-17: A Target to Increase Chemotherapeutic Efficacy in Colorectal Cancer?
Autor: Robert B. Diasio, Adam M. Lee
Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3966180f72450790330aa9e0cc48690
https://doi.org/10.1158/1078-0432.c.6518311.v1
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10
Data from Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas
Autor: Frank A. Sinicrope, Robert B. Jenkins, Robert B. Diasio, Tsung-Teh Wu, Axel Grothey, Christopher A. Sattler, Maliha Khan, Anne E. Wiktor, William R. Sukov, Qian Shi, Harry H. Yoon
Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2 protein expression and gene amplification in patients with curatively resected esophageal adenocarcinoma (EAC).Experimental Design: HER2 expression was analyzed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec9967d1363fee8d0978632042d1e1
https://doi.org/10.1158/1078-0432.c.6519704.v1
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