Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

Autor: Gillian Farnie, Pamela M Willan, Robert B Clarke, Nigel J Bundred

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56840 (2013)

Pathways involved in DCIS stem and progenitor signalling are poorly understood yet are critical to understand DCIS biology and to develop new therapies. Notch and ErbB1/2 receptor signalling cross talk has been demonstrated in invasive breast cancer,

Externí odkaz: https://doaj.org/article/3c976276baef469e838d2f525a5d9bbd

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

Autor: Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández, Faye Su, Kui Lin, Robert B. Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C. Turner, Aleix Prat, Paolo Nuciforo, Rodrigo Dienstmann, Chandra S. Verma, Nuria Lopez-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

CDK4/6 inhibitor resistance is common in breast cancer. Here, the authors show that p16 overexpression may be linked to reduced efficacy of CDK4/6 inhibition, and show that the combination with PI3K inhibitors may increase anti-tumour effects.

Externí odkaz: https://doaj.org/article/c3a330e420d34dc992aab0ec2b80986a

Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

Autor: Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández, Faye Su, Kui Lin, Robert B. Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C. Turner, Aleix Prat, Paolo Nuciforo, Rodrigo Dienstmann, Chandra S. Verma, Nuria Lopez-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/c47a0b935486445aafab933f5d652620

RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells

Autor: Fuhui Chen, Sevim B. Gurler, David Novo, Cigdem Selli, Denis G. Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys, Antony Adamson, Andrew Campbell, Owen J. Sansom, Cathy Tournier, Robert B. Clarke, Keith Brennan, Charles H. Streuli, Ahmet Ucar

Publikováno v: Chen, F, Gurler, S B, Novo, D, Selli, C, Alferez, D G, Eroglu, S, Pavlou, K, Zhang, J, Sims, A H, Humphreys, N E, Adamson, A, Campbell, A, Sansom, O J, Tournier, C, Clarke, R B, Brennan, K, Streuli, C H & Ucar, A 2023, ' RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells ', Oncogene, vol. 42, pp. 679-692 . https://doi.org/10.1038/s41388-022-02574-6

Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by their heterogeneity and the lack of BCSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1327f89053608b065c8bcfc5ed3d5f
https://doi.org/10.1038/s41388-022-02574-6

Data from The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling

Autor: Robert B. Clarke, Weichun Guo, Zhengfu Fan, Rachel Eyre, Bruno M. Simões, Xiangran Sun, Zhengpei Zhang, Jingteng Chen, Tian Gao, Kezhou Xia, Ling Yu

Despite significant advancements in the diagnosis and treatment of osteosarcoma, the molecular mechanisms underpinning disease progression remain unclear. This work presents strong clinical and experimental evidence demonstrating that Notch signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12359982e88797afe326b09596add8b1
https://doi.org/10.1158/1541-7786.c.6540207.v1