Výsledky vyhledávání - "Robert B, Johnson"

Optimization of Laboratory Ordering Practices for Complete Blood Count With Differential

Autor: Sherry R Polhill, Jeffrey Z. Shen, Robin G. Lorenz, Robert B Johnson, Paula Evans, Vishnu Reddy, David P Galloway, Patrick L. Bosarge, Lisa A Rice-Jennings, Benjamin Hill

Publikováno v: American Journal of Clinical Pathology. 151:306-315

Objectives To investigate the utilization of CBC and CBC with differential (CBC w/diff) tests at University of Alabama at Birmingham Hospital, and to determine if a reduction in CBC w/diff tests could be achieved without negatively impacting patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c2e1ac2dd86b1bda0a29bf9867780f
https://doi.org/10.1093/ajcp/aqy146

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Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in mice

Autor: Peter Adamson, Gene Hung, Brett P. Monia, Lisa Hettrick, Robert B. Johnson, Tamar R. Grossman, Raechel Peralta, Scott P. Henry, Michael L. McCaleb, Andrew T. Watt

Publikováno v: Immunobiology. 221:701-708

Systemic lupus erythematosus is an autoimmune disease that manifests in widespread complement activation and deposition of complement fragments in the kidney. The complement pathway is believed to play a significant role in the pathogenesis and in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c887a727d476bc86f9808f9a7783e7
https://doi.org/10.1016/j.imbio.2015.08.001

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Abstract 5561: High-affinity antisense oligonucleotides targeting Foxp3 inhibit immunosuppressive function of regulatory T-cells and produce antitumor effects in syngeneic tumor models

Autor: Lisa A. Hettrick, Molly A. Taylor, Andrew Watt, Anna Staniszewska, Brett T. Monia, Paul Lyne, Alexey S. Revenko, Simon T. Barry, A. Hughes, Charles Sinclair, Alison Peter, Mark Edbrooke, Lisa Sandin, Robert B. Johnson, Stephanie Klein, A. Robert MacLeod

Publikováno v: Cancer Research. 78:5561-5561

Regulatory T-cells (Treg) contribute to cancer progression by suppressing anti-tumor immuity. Tregs specifically require expression of the lineage defining transcription factor Foxp3 for their development and function, but this protein cannot be targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15259f294a96a05b1b94aedcb409e52e
https://doi.org/10.1158/1538-7445.am2018-5561

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Outcome of Extremely Preterm Infants Randomized at Birth to Different PaCO2 Targets during the First Seven Days of Life

Autor: Robert B. Johnson, William Carroll, Daniel Young, Ulrich Thome, Tzong-Jin Wu, Claire Roane, Waldemar A. Carlo

Publikováno v: Neonatology. 90:218-225

Background: Ventilation with higher PaCO2 goals may reduce lung injury and bronchopulmonary dysplasia (BPD). The effect may be enhanced by using a higher PaCO2 goal than in previous trials. Objective: To determine the clinical benefits and safety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce03b92d7d10080edde0a0fadd7468a7
https://doi.org/10.1159/000092723

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Solid-Phase Synthesis and Screening of Macrocyclic Nucleotide-Hybrid Compounds Targeted to Hepatitis C NS5B

Autor: Eric T. Kool, Q. May Wang, Robert B. Johnson, Michael Smietana

Publikováno v: Chemistry - A European Journal. 10:173-181

A convergent strategy for the synthesis of cyclic nucleotide-hybrid molecules on controlled pore glass is reported. A major advantage of the approach is the lack of restrictions on the sequence and structural variation, allowing the incorporation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8738272da48cebb5035527afb180fb9c
https://doi.org/10.1002/chem.200305402

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P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

Autor: Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:257-261

With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f275bbea4f02e46d25f244e2fcf482cd
https://doi.org/10.1016/j.bmcl.2003.09.075

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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

Autor: Jason Eric Lamar, Ling Jin, Daryl Venable, Lifei Liu, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Q. May Wang, Yip Yvonne Yee Mai, Donna Barket, Robert B. Johnson, Joe Colacino, Mark Wakulchik, John E. Munroe, Beverly A. Heinz, John I. Glass, Congping Xie, Elcira C. Villarreal

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:251-256

We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03ae4d6ce258904c379bc3ebcafdec6
https://doi.org/10.1016/j.bmcl.2003.09.074

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