Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Robert B, Dickson"'
Autor:
Peter P. Roller, Pao-Yi Huang, Eun-Gyung Cho, Sheau-Ling Lee, Dongeun Park, Robert B. Dickson
Publikováno v:
Mechanisms of Development. 127(1-2):82-95
The epithelial-derived, type II transmembrane serine protease matriptase, the mouse homologue of which is epithin, has been shown to be involved in epidermal differentiation, hair formation, and thymus function. We show in this study that epithin/mat
Autor:
Glenn Merlino, T.-H. Qiu, Jung-Im Huh, Oscar Gonzalez-Moreno, Mark D. Johnson, R. Sharp, Ignacio Gil-Bazo, Miriam R. Anver, Raul Catena, Jeffrey Green, D.E. Carbott, Alfonso Calvo, Robert B. Dickson, M. S. Noble
Publikováno v:
Oncogene. 27:5373-5384
Metastasis is the primary cause of death in patients with breast cancer. Overexpression of c-myc in humans correlates with metastases, but transgenic mice only show low rates of micrometastases. We have generated transgenic mice that overexpress both
Autor:
Jane Fridlyand, Terence P. Speed, Anna Lapuk, Frank McCormick, Wen-Lin Kuo, Marc E. Lippman, Michael D. Johnson, Nicholas J. Wang, Nora Bayani, Joe W. Gray, Jennifer Yeh, Laura Clark, Koei Chin, Robert B. Dickson, Stephen P. Ethier, Sandy DeVries, Frances Tong, Donna G. Albertson, F. M. Waldman, Frederick L. Baehner, Jackie L. Stilwell, Adi F. Gazdar, Jean-Philippe Coppe, Tea Fevr, Daniel Pinkel, Richard M. Neve, Paul T. Spellman
Publikováno v:
Cancer Cell. 10(6):515-527
Summary Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model ‘‘system’’ to appraise the functional contributions of these
Autor:
Robert J. Barndt, Chen-Yong Lin, Ming-Shyue Lee, Michael D. Johnson, Ken-ichi Kiyomiya, I-Chu Tseng, Hong Zuo, Robert B. Dickson
Publikováno v:
American Journal of Physiology-Cell Physiology. 291:C40-C49
Matriptase and its cognate inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), have been implicated in carcinoma onset and malignant progression. However, the pathological mechanisms of matriptase activation are not defined. Steroid se
Autor:
Sanjida Ahmed, Chen-Yong Lin, Kaoru Miyazaki, Yuichiro Sato, Motoki Yagi, Shouichi Higashi, Chie Yasuda, Robert B. Dickson, Xinlian Jin
Publikováno v:
FEBS Journal. 273:615-627
Insulin-like growth factor (IGF) binding protein-related protein-1 (IGFBP-rP1) modulates cellular adhesion and growth in an IGF/insulin-dependent or independent manner. It also shows tumor-suppressive activity in vivo. We recently found that a single
Autor:
Tamara Handerson, John M. Pawelek, Robert B. Dickson, Summar Siddiqui, Robert L. Camp, Chen-Yong Lin, David L. Rimm
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 14:2517-2523
β1,6-N-Acetylglucosaminyltransferase-V (GnT-V) catalyzes the addition of complex oligosaccharide side chains to glycoproteins, regulating the expression and function of several proteins involved in tumor metastasis. We analyzed the expression of fiv
Autor:
Ming-Shyue Lee, Michael D. Johnson, Li-Yuan L. Chen, Chen-Yong Lin, Michael D. Oberst, Ken-ichi Kiyomiya, Cicely A. Williams, Robert B. Dickson
Publikováno v:
American Journal of Physiology-Cell Physiology. 289:C462-C470
Hepatocyte growth factor activator inhibitor-1 (HAI-1) was initially identified as cognate inhibitor of matriptase, a membrane-bound serine protease. Paradoxically, HAI-1 is also required for matriptase activation, a process that requires sphingosine
Publikováno v:
American Journal of Physiology-Cell Physiology. 288:C932-C941
Activation of single-chain, latent matriptase, a type II transmembrane serine protease, depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor, hepatocyte growth factor activator inhibitor 1 (HAI-1). Oligomerizat
Autor:
Tomomi Hirosaki, Chen-Yong Lin, Xinlian Jin, Hitoshi Kitamura, Robert B. Dickson, Kaoru Miyazaki, Shouichi Higashi
Publikováno v:
Journal of Cellular Biochemistry. 95:632-647
The membrane-bound serine proteinase matriptase, which is often released from the plasma membrane of epithelial and carcinoma cells, has been implicated to play important roles in both physiological and pathological conditions. However, the regulator