Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Robert Almassy"'
Autor:
Richard E. Showalter, Jim Thomson, Yudou He, Mario Meng-Chiang Kuo, Richard Hickey, Wei-Jong Shia, Li-Chang Chen, Elena Brin, Eleanor Dagostino, Katherine Wu, Robert Almassy, Mariusz Stempniak
Publikováno v:
Oncotarget
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920a1fcfc2cf7ef29450ed87d9dde742
http://europepmc.org/articles/PMC6319333
http://europepmc.org/articles/PMC6319333
Autor:
Robert Almassy, Theodore J. Boritzki, Karen A. Maegley, Bernard T. Golding, Suzanne Kyle, Huw D. Thomas, Stephen E. Webber, Tikhe Jayashree Girish, A. Hilary Calvert, Nicola J. Curtin, Xiao-Hong Yu, Jianke Li, Zdenek Hostomsky, Roger John Griffin, David Richard Newell, Anne Ekkers, Cathy Zhang, Robert Arnold Kumpf, Christopher R. Calabrese, Lan-Zhen Wang
Publikováno v:
Journal of Medicinal Chemistry. 47:5467-5481
The design, synthesis, and biological evaluation of potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) are reported. A novel series of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones were designed using a combination of protein structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82337c486d0f3a91ab902b0d1cdaeec
https://doi.org/10.1021/jm030513r
https://doi.org/10.1021/jm030513r
Autor:
Victor I. Nikulin, Sam Chu, Martina E. Tedder, Kelly Sprankle, Kraig M. Yager, Mitra Khalili, Krzysztof Appelt, Li Xiaoming, James Levin, Victoria A. Feher, Stephen Margosiak, Robert Almassy, Zhe Nie
Publikováno v:
Journal of Medicinal Chemistry. 46:5663-5673
The structure-based design, synthesis, and biological activity of a novel indazole-containing inhibitor series for S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Use of 5-aminoindazole as the core scaffold provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75136456785a1ac521969016bd6b47ca
https://doi.org/10.1021/jm0302039
https://doi.org/10.1021/jm0302039
Autor:
Marakovits Joseph T, David R. Newell, Stephen E. Webber, Zdenek Hostomsky, Roger J. Griffin, Karen A. Maegley, Anne Ekker, Skalitzky Donald James, Bernard T. Golding, Robert Almassy, A. Hilary Calvert, Xiao-Hong Yu, Jianke Li, Eastman Brian Walter, Nicola J. Curtin
Publikováno v:
Journal of Medicinal Chemistry. 46:210-213
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines. In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e30269eae330ae9f62d49beef30fe44
https://doi.org/10.1021/jm0255769
https://doi.org/10.1021/jm0255769
Autor:
Huw D. Thomas, Anne Ekker, Stephen E. Webber, Christopher R. Calabrese, Nicola J. Curtin, Robert Almassy, Karen A. Maegley, Rena N. Mansour, Lan-Zhen Wang, Robert Arnold Kumpf, A. Hilary Calvert, Cathy Zhang, Scott E. Zook, Jianke Li, Bernard T. Golding, Tikhe Jayashree Girish, Xiao-Hong Yu, Suzanne Kyle, Zdenek Hostomsky, Theodore J. Boritzki, Thoresen Lars Henrik, David Richard Newell, Kanyin E. Zhang, Stacie S. Canan Koch, Roger John Griffin
Publikováno v:
Journal of Medicinal Chemistry. 45:4961-4974
A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties have been characterized. The new structural classes, 3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec741e627bfb818de6119c89a2082ae7
https://doi.org/10.1021/jm020259n
https://doi.org/10.1021/jm020259n
Autor:
S Srinivasan, Bernard T. Golding, Alex William White, Karen A. Maegley, David R. Newell, Roger J. Griffin, A. Hilary Calvert, Robert Almassy, Nicola J. Curtin, Zdenek Hostomsky
Publikováno v:
Journal of Medicinal Chemistry. 43:4084-4097
The nuclear enzyme poly(ADP-ribose) polymerase (PARP) facilitates the repair of DNA strand breaks and is implicated in the resistance of cancer cells to certain DNA-damaging agents. Inhibitors of PARP have clinical potential as resistance-modifying a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d700fd53291c78ab1d6a029fa4be86
https://doi.org/10.1021/jm000950v
https://doi.org/10.1021/jm000950v
Autor:
R. Ferre, Varney Michael D, William H. Romines, Theodore Boritzki, Eleanor J. Howland, Cheryl Ann Janson, Stephen Margosiak, Cindy L. Palmer, Robert Almassy, Charlotte A. Bartlett
Publikováno v:
Journal of Medicinal Chemistry. 40:2502-2524
The design, synthesis, biochemical, and biological evaluation of a novel series of 5-thia-2,6-diamino-4(3H)-oxopyrimidine inhibitors of glycinamide ribonucleotide transformylase (GART) are described. The compounds were designed using the X-ray crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d7bb56b90be1756424d65b56ec129b
https://doi.org/10.1021/jm9607459
https://doi.org/10.1021/jm9607459
Autor:
Cindy L. Palmer, Robert Almassy, R. Ferre, Theodore Boritzki, Charlotte A. Bartlett, Stephen Margosiak, Varney Michael D, Eleanor J. Howland, Cheryl Ann Janson, William H. Romines
Publikováno v:
ChemInform. 28
The design, synthesis, biochemical, and biological evaluation of a novel series of 5-thia-2,6-diamino-4(3H)-oxopyrimidine inhibitors of glycinamide ribonucleotide transformylase (GART) are described. The compounds were designed using the X-ray crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64005d957167a5f2b9b0044361cf9cc5
https://doi.org/10.1002/chin.199748184
https://doi.org/10.1002/chin.199748184
Autor:
Eunice Li, Scott A. Mitchell, Kevin Farley, Thomas H. Chyba, Steven Simpson, Ryan Da Re, Jay Pendell-Jones, Darren K. Emge, Robert Almassy, Timothy Reed, Ahmed Slamani, Christin Gunning, David Baughman, Mohamed-Adel Slamani, Amber Polizzi, Steven Andrew MacDonald, Brian Fisk
Publikováno v:
SPIE Proceedings.
A procedure to evaluate and optimize the performance of a chemical identification algorithm is presented. The Joint Contaminated Surface Detector (JCSD) employs Raman spectroscopy to detect and identify surface chemical contamination. JCSD measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f6ffa2738ff44c5c758aa537886bf5
https://doi.org/10.1117/12.850529
https://doi.org/10.1117/12.850529
Autor:
Carin L. Perretta, April Averill, Shaosong Chu, Robert Almassy, Stephen Margosiak, Jia Lu, Zhe Nie, Erickson Philip Eugene
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
A series of macrocyclic derivatives has been designed and synthesized based on the X-ray co-crystal structures of pyrazolo[1,5-a] [1,3,5]triazines with corn CK2 (cCK2) protein. Bioassays demonstrated that these macrocyclic pyrazolo[1,5-a] [1,3,5]tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f808ebafe4ac8e7b8eb58ad3f443947
https://pubmed.ncbi.nlm.nih.gov/18055206
https://pubmed.ncbi.nlm.nih.gov/18055206