Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Robert Alan Goodnow"'
Autor:
Matthias Zentgraf, Elizabeth Krutoholow, Thomas S. Rush, Chris Luebkemann, Kimito Funatsu, Gisbert Schneider, Jeff Blaney, Alleyn T. Plowright, Norman Sieroka, John Edward Hill, Petra Schneider, Jennifer Listgarten, José S. Duca, Robert Alan Goodnow, Johanna M. Jansen, Jasmin Fisher, Matthias Kohler, W. Patrick Walters
Publikováno v:
Nature Reviews Drug Discovery. 19:353-364
Artificial intelligence (AI) tools are increasingly being applied in drug discovery. While some protagonists point to vast opportunities potentially offered by such tools, others remain sceptical, waiting for a clear impact to be shown in drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53001ef1a373cf62d629543029f92869
https://doi.org/10.1038/s41573-019-0050-3
https://doi.org/10.1038/s41573-019-0050-3
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a633bbb07d24cb3c7b6963f9c8c2b89d
https://doi.org/10.1016/j.bmcl.2014.04.049
https://doi.org/10.1016/j.bmcl.2014.04.049
Autor:
Nader Fotouhi, T. Szommer, Tamas Meszaros, Dmytro Tymoshenko, Jozsef Kovacs, Paul Gillespie, Tamas Nagy, Agnieszka Kowalczyk, Gyorgy Jeges, Robert Alan Goodnow
Publikováno v:
Synlett. 2011:203-206
The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b5af11463a8fa617e030aa2494dc72
https://doi.org/10.1055/s-0030-1259283
https://doi.org/10.1055/s-0030-1259283
Publikováno v:
Synthetic Communications. 40:3691-3698
The synthesis of various aryl methyl sulfides has been achieved by treatment of nitroarenes with a combination of (methylthio)trimethylsilane and cesium carbonate in dimethylsulfoxide. This reaction gives access to aryl methyl sulfide derivatives in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f149e1b98ad773dd0d208c289183e870
https://doi.org/10.1080/00397910903531664
https://doi.org/10.1080/00397910903531664
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f954d2982302b35c7516d54421fb833
https://doi.org/10.1021/jm1001919
https://doi.org/10.1021/jm1001919
Publikováno v:
Expert Opinion on Drug Discovery. 3:733-744
Background: Lead generation is a critical element in the successful discovery of new drugs. Scientists engaged in lead generation are faced with a huge array of strategies and technologies, and new approaches are constantly emerging. In part as a rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1c5c07598a9f0b6435971b7b5dc87e
https://doi.org/10.1517/17460441.3.7.733
https://doi.org/10.1517/17460441.3.7.733
Publikováno v:
Tetrahedron Letters. 49:3682-3686
A variety of 2,4-disubstituted-5-acetoxythiazoles were prepared from the substituted methyl benzoates in good to moderate yields using a three-step sequence: (1) ester to thionoester conversion, (2) coupling with an amino acid, and (3) acetic anhydri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63db9497b131fb5600d8f548781b2f50
https://doi.org/10.1016/j.tetlet.2008.03.140
https://doi.org/10.1016/j.tetlet.2008.03.140
Autor:
Lucía Díaz, Marta Corrales, Hermann Gesine Johanna, Robert Alan Goodnow, Peter D. Edwards, Michael C. Annis
Publikováno v:
Synthesis. 2008:221-224
An efficient method for the preparation of novel 3-alkyl- and 3-aryl-4-iodophenols from 3-alkyl- and 3-arylphenols is de- scribed. As part of an ongoing project it was necessary to access a series of novel 4-arylphenols containing sterically de- mand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801c2b64cb3629b3c6823e90855ff52e
https://doi.org/10.1055/s-2007-1000860
https://doi.org/10.1055/s-2007-1000860
Publikováno v:
Expert Opinion on Investigational Drugs. 16:1909-1920
Leukotriene B(4) (LTB(4)) is a lipid inflammatory mediator derived from membrane phospholipids by the sequential actions of cytosolic phospholipase A2 (PLA2), 5-lipoxygenase (5-LO) and leukotriene A(4) (LTA(4)) hydrolase. Several inflammatory disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a25817cd57fe22c3b4796a2bb088ab
https://doi.org/10.1517/13543784.16.12.1909
https://doi.org/10.1517/13543784.16.12.1909
Autor:
Goli Naderi-Oboodi, Quentin Strebel, Ann C. Petersen, Lucja Orzechowski, Jianping Cai, Agnieszka Kowalczyk, Yi Chen, Alexander L. Satz, Felix Gruber, Robert Alan Goodnow
Publikováno v:
Bioconjugate chemistry. 26(8)
Complex mixtures of DNA encoded small molecules may be readily interrogated via high-throughput sequencing. These DNA encoded libraries (DELs) are commonly used to discover molecules that interact with pharmaceutically relevant proteins. The chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24345025a5a88a377a98385d9c5ab98a
https://pubmed.ncbi.nlm.nih.gov/27643718
https://pubmed.ncbi.nlm.nih.gov/27643718