Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Robert Aggeler"'
Publikováno v:
Analytical and bioanalytical chemistry. 413(20)
Antibody drug conjugates (ADCs) represent a rapidly growing modality for the treatment of numerous oncology indications. The complexity of analytical characterization method development is increased due to the potential for synthetic intermediates an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8c12f4dc5ec3102b7598cc3f6820a3
https://pubmed.ncbi.nlm.nih.gov/34231000
https://pubmed.ncbi.nlm.nih.gov/34231000
Autor:
Wolfgang W. Scholz, Robert Aggeler, Jason S. Lewis, Jacob L. Houghton, Brian M. Zeglis, Ritsuko Sawada, Dalya Abdel-Atti, Brian Agnew
Publikováno v:
Proceedings of the National Academy of Sciences. 112:15850-15855
Molecular imaging agents for preoperative positron emission tomography (PET) and near-infrared fluorescent (NIRF)-guided delineation of surgical margins could greatly enhance the diagnosis, staging, and resection of pancreatic cancer. PET and NIRF op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc482be44a26ece12842e5577d6102b
https://doi.org/10.1073/pnas.1506542112
https://doi.org/10.1073/pnas.1506542112
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973552
High content screening (HCS)-based multiparametric measurements are very useful in early toxicity testing and safety assessment during drug development, and useful in evaluating the impact from new food supplements and environmental toxicants. Mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab43abf12d9a89f3e67a5ceb1f844a3
https://doi.org/10.1007/978-1-4939-7357-6_3
https://doi.org/10.1007/978-1-4939-7357-6_3
Autor:
Yi-Zhen Hu, Wu Yexin, Robert Aggeler, Aimei Chen, Xin Wang, Hee Chol Kang, Quentin Low, Kyle R. Gee
Publikováno v:
Chemical communications (Cambridge, England). 52(21)
A series of novel water-soluble PEGylated dibenzosilole-based conjugated polymers were prepared as ultra-bright fluorescent labels for biomolecules. Due to their superior solubility and brightness, antibody conjugates labeled with functionalized poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13d331257610835f7059113118c8139
https://pubmed.ncbi.nlm.nih.gov/26888307
https://pubmed.ncbi.nlm.nih.gov/26888307
Autor:
Chris Langsdorf, Robert Aggeler, Aimei Chen, Nicholas Dolman, Yi-Zhen Hu, Lynn Kamen, Bhaskar Mandavilli, Benjamin Ordonia, Marcy Wickett
Publikováno v:
The Journal of Immunology. 200:120.42-120.42
Immunoglobulin antibodies contribute to a broad range of research assays and also provide the foundation for a diverse variety of biopharmaceutical agents. Here we describe the use of bio-orthogonal click chemistry reactions to synthesize several com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cf72d4bae4272bf6f87eb777dcd183
https://doi.org/10.4049/jimmunol.200.supp.120.42
https://doi.org/10.4049/jimmunol.200.supp.120.42
Publikováno v:
Toxicology in Vitro. 21:902-911
Mitochondrial dysfunction has been shown to be a pharmacotoxicological response to a variety of currently-marketed drugs. In order to reduce attrition due to mitochondrial toxicity, high throughput-applicable screens are needed for early stage drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81012d2e06191c9faee887799d4a3adb
https://doi.org/10.1016/j.tiv.2007.01.011
https://doi.org/10.1016/j.tiv.2007.01.011
Autor:
Birgit Schilling, Roderick A. Capaldi, Robert Aggeler, James Murray, Richard H. Row, Birte Schulenberg, Bradford W. Gibson
Publikováno v:
FEBS Letters. 579:2485-2490
Mitochondrial Complex I (NADH:ubiquinone oxidoreductase) consists of at least 46 subunits. Phosphorylation of the 42-kDa subunit NDUFA10 was recently reported using a novel phosphoprotein stain [Schulenberg et al. (2003) Analysis of steady-state prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48bf2f135aa9f80a0a6c16b6de11843
https://doi.org/10.1016/j.febslet.2005.03.061
https://doi.org/10.1016/j.febslet.2005.03.061
Publikováno v:
ELECTROPHORESIS. 25:2526-2532
Protein phosphorylation plays a vital role in the regulation of most aspects of cellular activity, being key to propagating messages within signal transduction pathways and to modulating protein function. Pro-Q® Diamond phosphoprotein gel stain is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7b5aa36e9e44808ce868fcb8e4d73e
https://doi.org/10.1002/elps.200406007
https://doi.org/10.1002/elps.200406007
Autor:
Roger Y. Tsien, Mark B. Cannon, S. James Remington, Robert Aggeler, Roderick A. Capaldi, Devin Oglesbee, George T. Hanson
Publikováno v:
Journal of Biological Chemistry. 279:13044-13053
Current methods for determining ambient redox potential in cells are labor-intensive and generally require destruction of tissue. This precludes single cell or real time studies of changes in redox poise that result from metabolic processes or enviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9c677460654a0cf669148b3be2289e
https://doi.org/10.1074/jbc.m312846200
https://doi.org/10.1074/jbc.m312846200
Autor:
Rodrigue Rossignol, Robert Gilkerson, Michelle K. Knowles, Daciana Margineantu, Michael F. Marusich, George T. Hanson, James Murray, Andrew H. Marcus, Devin Oglesbee, Roderick A. Capaldi, Robert Aggeler, S. James Remington
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1555(1-3):192-195
The mitochondrion within human cells in tissue culture is pleomorphic and highly dynamic. The organelle mass can exist as thousands of small ovoids or as one continuous reticulum. In either state, the mitochondrial mass is in constant thermal motion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e7b220edbb9539247c62619cee6337