Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert A. Zambias"'
Autor:
Catherine James, Richard Hajdu, Randy Thompson, Jean A. Marrinan, Bartizal Kenneth F, James M. Balkovec, George K. Abruzzo, Robert A. Zambias, Karl H. Nollstadt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2021-2026
Amine conjugates of the semi-synthetic 1,3-β-(D)-glucan synthesis inhibitors L-731,373 (3) and L-733,560 (4) were prepared and evaluated for in vitro and in vivo antifungal activity. Tricationic analogs were more potent than the dicationic which wer
Publikováno v:
Proceedings of the National Academy of Sciences. 92:10212-10216
Combinatorial chemistry is gaining wide appeal as a technique for generating molecular diversity. Among the many combinatorial protocols, the split/recombine method is quite popular and particularly efficient at generating large libraries of compound
Autor:
George K. Abruzzo, Robert A. Zambias, Bartizal Kenneth F, Jean A. Marrinan, Catherine James, Milton L. Hammond, Karl H. Nollstadt, Cameron M. Douglas, James M. Balkovec
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2357-2362
Selective methanolysis or dehydration followed by reduction of the 3-hydroxyglutamine residue of pneumocandin B0 (1) or its dideoxy analog 5 (L-692,289) gave the methyl 3-hydroxyglutamate and 3-hydroxyornithine analogs 6 and 9, respectively. Further
Publikováno v:
Tetrahedron Letters. 35:4283-4286
New methodology utilizing matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF MS) for the direct identification of a ligand covalently attached to a polymeric bead is reported. The method allows for structure deter
Autor:
Robert A. Zambias, Milton L. Hammond
Publikováno v:
ChemInform. 22
ChemInform Abstract: Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives
Autor:
James M. Balkovec, Myra B. Kurtz, D C McFadden, Robert A. Zambias, M A Powles, Bartizal Kenneth F, Jean A. Marrinan, George K. Abruzzo, Frances Aileen Bouffard, Karl H. Nollstadt, James F. Dropinski, Milton L. Hammond, Dennis M. Schmatz
Publikováno v:
ChemInform. 25
The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic
Autor:
Sumire V. Kobayashi, Dana N. Cianciarulo, Thomas E. Rollins, Robert A. Zambias, Salvatore J. Siciliano, Charles G. Caldwell, Steven S. Bondy, Joung L. Goulet, Joshua S. Boger, Martin S. Springer, Milton L. Hammond, Philippe L. Durette, Joanne F. Kinneary, William K. Hagmann, Thomas J. Lanza, Ihor E. Kopka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1033-1038
The cyclic hexadepsipeptide antibiotic L-156,602 ( 1 ) was found to be an inhibitor of anaphylatoxin C5a binding to its receptor (IC 50 =1.7 μg/mL). This compound also caused nonspecific degranulation of neutrophils, but not through interactions wit
Autor:
Dennis M. Schmatz, James V. Heck, Milton L. Hammond, Charlotte Trainor, K Nollstadt, Robert A. Zambias, George K. Abruzzo, Ken Bartizal
Publikováno v:
Journal of Medicinal Chemistry. 35:2843-2855
The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species. The mechanism of action of the echinocandins is generally thought to be the inhibition of beta-1,3-glucan synthesis, a
Autor:
Milton L. Hammond, Robert A. Zambias
Publikováno v:
Synthetic Communications. 21:959-964
The preparation of 5-hydroxy-2,3-dihydrobenzothiophene 1 from 5-nitro-benzothiophene-2-carboxylate 3a is described along with an efficient one pot synthesis of 3a.
Autor:
M A Powles, L A Pittarelli, Robert A. Zambias, Milton L. Hammond, D C McFadden, James M. Balkovec, Jennifer W. Anderson, Dennis M. Schmatz, Paul A. Liberator
Water-soluble lipopeptide L-693,989 was evaluated for its antipneumocystis activity in rats. Rats from colonies with latent Pneumocystis carinii infections were immunosuppressed with dexamethasone for 6 weeks to facilitate the development of acute P.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08595207bc1539e533e641671d880b43
https://europepmc.org/articles/PMC192216/
https://europepmc.org/articles/PMC192216/