Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Robert A. Zakharyan"'
Publikováno v:
Vacuum. 184:109964
The joint of the internal parts of various vacuum devices with adhesive allows you to simplify the assembly technology and reduce their cost. However, the use of adhesive leads to the release of volatile products into the internal volume of the devic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d4d8de13b18ee00d806c3e1cff7317
https://doi.org/10.1016/j.vacuum.2020.109964
https://doi.org/10.1016/j.vacuum.2020.109964
Autor:
H. Vasken Aposhian, Michael J. Kopplin, Mihaela D. Avram, Robert A. Zakharyan, Uttam K. Chowdhury, Alba Hernández
Publikováno v:
Toxicology and Applied Pharmacology. 216:446-457
Inorganic arsenic is a human carcinogen to which millions of people are exposed via their naturally contaminated drinking water. Its molecular mechanisms of carcinogenicity have remained an enigma, perhaps because arsenate is biochemically transforme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e4de4853b8b40ffd7e7e4e78b57b9a
https://doi.org/10.1016/j.taap.2006.06.014
https://doi.org/10.1016/j.taap.2006.06.014
Publikováno v:
Acta Biochimica Polonica. 53:547-552
Human glutathione S-transferase omega 1-1 (hGSTO1-1) is a newly identified member of the glutathione S-transferase (GST) family of genes, which also contains alpha, mu, pi, sigma, theta, and zeta members. hGSTO1-1 catalyzes the reduction of arsenate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833801b689c911998c0fbf96cb929407
https://doi.org/10.18388/abp.2006_3326
https://doi.org/10.18388/abp.2006_3326
Publikováno v:
Biomedicine & Pharmacotherapy. 60:238-244
Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are present in all living organisms. Their main function is the detoxification of electrophilic compounds. Glutathione conjugation is the major detoxification pathway avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc70f139dce245768b8bbde7781154c4
https://doi.org/10.1016/j.biopha.2006.04.005
https://doi.org/10.1016/j.biopha.2006.04.005
Autor:
Robert A. Zakharyan, Michael L. Wollenberg, Mihaela D. Avram, H. Vasken Aposhian, Adriana Sampayo-Reyes
Publikováno v:
Toxicology and Applied Pharmacology. 198:327-335
This laboratory has studied the enzymology involved in the biotransformation of inorganic arsenic to dimethylarsinous acid (DMA(III)) and in human studies established that monomethylarsonous acid (MMA(III)) and DMA(III) appear in urine of people chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758ab6d818c96ec4a28438e2ddb0fd16
https://doi.org/10.1016/j.taap.2003.10.027
https://doi.org/10.1016/j.taap.2003.10.027
Autor:
Robert A. Zakharyan, Mihaela D. Avram, Michael L. Wollenberg, H. Vasken Aposhian, Michael J. Kopplin
Publikováno v:
Toxicology and Applied Pharmacology. 193:1-8
Arsenic compounds with a +3 oxidation state are more toxic than analogous compounds with a +5 oxidation state, for example, arsenite versus arsenate, monomethylarsonous acid (MMA(III)) versus monomethylarsonic acid (MMA(V)), and dimethylarsinous acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01808e88a22be72e5e68a863fe773c1
https://doi.org/10.1016/s0041-008x(03)00324-7
https://doi.org/10.1016/s0041-008x(03)00324-7
Publikováno v:
Chemical Research in Toxicology. 13:1181-1186
The formation of monomethylarsonous acid (MMA(III)) by tissue homogenates of brain, bladder, spleen, liver, lung, heart, skin, kidney, or testis of male Golden Syrian hamsters was assessed using [(14)C]monomethylarsonic acid (MMA(V)) as the substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaea277560cdec8561ac393beaf05be
https://doi.org/10.1021/tx000154s
https://doi.org/10.1021/tx000154s
Autor:
H. Vasken Aposhian, Gerald F. O'Malley, R M Maiorino, Mingsheng Ma, Richard C. Dart, Wayne A. Van Voorhies, Robert A. Zakharyan, Luke Yip, William R. Cullen, Paul Andrewes, Baoshan Zheng, Allison Titcomb, Mariano E. Cebrián, Sheila M. Healy, Mary M. Aposhian, X. Chris Le, Zhai Cheng
Publikováno v:
Toxicology and Applied Pharmacology. 165:74-83
The administration of sodium 2,3-dimercapto-1-propane sulfonate (DMPS) to humans chronically exposed to inorganic arsenic in their drinking water resulted in the increased urinary excretion of arsenic, the appearance and identification of monomethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4e866979713aac896402c372c81e46
https://doi.org/10.1006/taap.2000.8922
https://doi.org/10.1006/taap.2000.8922
Publikováno v:
Toxicology and Applied Pharmacology. 158:9-15
Inorganic arsenite is methylated by some, but not all, animal species to dimethylarsinic acid (DMA). The monomethyl compound containing arsenic in an oxidation state of +3 has been proposed as an intermediate. Using highly purified arsenic methyltran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0734edddcb94126b442c828255902790
https://doi.org/10.1006/taap.1999.8687
https://doi.org/10.1006/taap.1999.8687
Publikováno v:
Toxicology and Applied Pharmacology. 154:287-291
Although inorganic arsenic is methylated enzymatically by arsenic methyltransferases, which have been found in many mammalian livers, the detection of such enzymes has not been successful in surgically removed human livers. Results of the present exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6bd585cbc2aed8b0d3d95748d74dab
https://doi.org/10.1006/taap.1998.8587
https://doi.org/10.1006/taap.1998.8587