Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Robert A. Thorne"'
Autor:
Abdallah W. Abdelhady, David W. Mittan-Moreau, Patrick L. Crane, Matthew J. McLeod, Soon Hon Cheong, Robert E. Thorne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Damage from ice and potential toxicity of ice-inhibiting cryoprotective agents (CPAs) are key issues in assisted reproduction of humans, domestic and research animals, and endangered species using cryopreserved oocytes and embryos. The natur
Externí odkaz:
https://doaj.org/article/900603d92ae8416db0b4013dd4348682
Blood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Many neuroscientists use the term Blood–Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothelial cells, rather than pointi
Externí odkaz:
https://doaj.org/article/7fba3f35a2594aaeadd273c81175ae8d
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Autor:
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Marcus Y Chin, Audrey Cheuk-Nga Ho, Rajarshi Ghosh, Dara E Leto, David Joy, Meredith EK Calvert, Joseph W Lewcock, Gilbert Di Paolo, Robert G Thorne, Zachary K Sweeney, Anastasia G Henry
Publikováno v:
eLife, Vol 12 (2023)
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis includ
Externí odkaz:
https://doaj.org/article/1459c4b9a28a4c35be189566695ad7a3
Autor:
Eunjeong Lee, Matthew J. McLeod, Jasmina S. Redzic, Barbara Marcolin, Robert E. Thorne, Pratul Agarwal, Elan Zohar Eisenmesser
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Biliverdin Reductase B (BLVRB) is an NADPH-dependent reductase that catalyzes the reduction of multiple substrates and is therefore considered a critical cellular redox regulator. In this study, we sought to address whether both structural and dynami
Externí odkaz:
https://doaj.org/article/d7b85ee18a9f4b2a81e64a103cab008c
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transge
Externí odkaz:
https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f
Autor:
Tyler Engstrom, Jonathan A. Clinger, Katherine A. Spoth, Oliver B. Clarke, David S. Closs, Richard Jayne, Benjamin A. Apker, Robert E. Thorne
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 867-877 (2021)
Based on work by Dubochet and others in the 1980s and 1990s, samples for single-particle cryo-electron microscopy (cryo-EM) have been vitrified using ethane, propane or ethane/propane mixtures. These liquid cryogens have a large difference between th
Externí odkaz:
https://doaj.org/article/4e852e51021f454c9428a4e2909601b8
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Publikováno v:
IUCrJ, Vol 8, Iss 5, Pp 784-792 (2021)
Time-resolved crystallography of biomolecules in action has advanced rapidly as methods for serial crystallography have improved, but the large number of crystals and the complex experimental infrastructure that are required remain serious obstacles
Externí odkaz:
https://doaj.org/article/08d4207bde694ed3ab91e4b1839b6b15
Autor:
Geetika Nehra, Shannon Andrews, Joan Rettig, Michael N. Gould, Jill D. Haag, Steven P. Howard, Robert G. Thorne
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising o
Externí odkaz:
https://doaj.org/article/10ae0b670c5e46fc889e1453f7c66a14