Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Robert A. Switzer"'
Autor:
Kuldip D. Dave, Shehan De Silva, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer, III, Syed O. Ahmad, Susan M. Sunkin, Dan Walker, Xiaoxia Cui, Daniel A. Fisher, Aaron M. McCoy, Kevin Gamber, Xiaodong Ding, Matthew S. Goldberg, Stanley A. Benkovic, Meredith Haupt, Marco A.S. Baptista, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 190-203 (2014)
Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset Parkinson's disease (PD). As part of its strategy to provide more tools f
Externí odkaz:
https://doaj.org/article/3b4ee316f83d4fc3bf43bea037f0fae8
Autor:
Anantharaman Muthuswamy, Ingrid D. Pardo, Robert C. Switzer, Brad Bolon, Deepa B. Rao, Alok K. Sharma
Publikováno v:
Toxicologic pathology. 49(3)
Visual system toxicity may manifest anywhere in the visual system, from the eye proper to the visual brain. Therefore, effective screening for visual system toxicity must evaluate not only ocular structures (ie, eye and optic nerve) but also multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1739a4c53071950c32a89a89432ac02
https://pubmed.ncbi.nlm.nih.gov/33243077
https://pubmed.ncbi.nlm.nih.gov/33243077
Autor:
Robert L. Switzer
Publikováno v:
Allosteric Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9514226ea4304d56531af13341f2dc5
https://doi.org/10.1201/9781003068563-5
https://doi.org/10.1201/9781003068563-5
Autor:
Karen Hayes, Reina N. Fuji, Lisa L. Shafer, Saileta Prabhu, William J. Meilandt, Keith R. Hildebrand, Ryan J. Watts, Thomas Keene, Jessica Couch, Blair Wilson, Jasvinder K. Atwal, Janice A. Maloney, Ann L. Daugherty, Kapil Gadkar, Kimberly Scearce-Levie, Kristin R. Wildsmith, Yanmei Lu, Andrew Kosky, Marisa Goo, Robert C. Switzer, Kun Peng, Eric Adams, Deepak R. Thakker, Pamela Chan, Deanna S. Lane, Lisa Jungbauer Nikolas, Hilda Solanoy, Daniela Bumbaca Yadav
Publikováno v:
British Journal of Pharmacology. 174:4173-4185
Background and Purpose The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood–brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficientl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0802c2e55ddcc52775ac9687bc8dd4
https://doi.org/10.1111/bph.14021
https://doi.org/10.1111/bph.14021
Autor:
Patrick M. Kochanek, Robert C. Switzer, Geoffrey Murdoch, C. Edward Dixon, Donna B. Stolz, Guoji Wang, Jonathan Franks, Andrew Lesniak, Ming Sun, Clayton A. Wiley, Stephanie J. Bissel
Publikováno v:
Journal of Neurotrauma. 33:1866-1882
We used controlled cortical impact in mice to model human traumatic brain injury (TBI). Local injury was accompanied by distal diaschisis lesions that developed within brain regions anatomically connected to the injured cortex. At 7 days after injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1804c018cfc5ac0dc424e512fc364d7f
https://doi.org/10.1089/neu.2015.4272
https://doi.org/10.1089/neu.2015.4272
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
Autor:
Martin Willemoës, Jan Martinussen, Bjarne Hove-Jensen, Mogens Kilstrup, Kasper R. Andersen, Robert L. Switzer
Publikováno v:
Hove-Jensen, B, Andersen, K R, Kilstrup, M, Martinussen, J, Switzer, R L & Willemoës, M 2017, ' Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance ', Microbiology and Molecular Biology Reviews, vol. 81, no. 1 . https://doi.org/10.1128/MMBR.00040-16
Hove-Jensen, B, Andersen, K R, Kilstrup, M, Martinussen, J, Switzer, R L & Willemoes, M 2017, ' Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance ', Microbiology and Molecular Biology Reviews, vol. 81, no. 1, e00040-16 . https://doi.org/10.1128/MMBR.00040-16
Hove-Jensen, B, Andersen, K R, Kilstrup, M, Martinussen, J, Switzer, R L & Willemoes, M 2017, ' Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance ', Microbiology and Molecular Biology Reviews, vol. 81, no. 1, e00040-16 . https://doi.org/10.1128/MMBR.00040-16
SUMMARY Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism. PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is used in su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc112452ccb7e85aa82a4d959f6f5c81
https://europepmc.org/articles/PMC5312242/
https://europepmc.org/articles/PMC5312242/
Autor:
Edwin K. Jackson, Patrick M. Kochanek, Richard A. Bauman, David V. Ritzel, Hülya Bayır, Steven Parks, Robert S. B. Clark, Peter V. Swauger, Valerian E. Kagan, Lawrence C. Tong, Larry W. Jenkins, Robert C. Switzer, Robert H. Garman, C. Edward Dixon
Publikováno v:
Journal of Neurotrauma. 28:947-959
Blast-induced traumatic brain injury (TBI) is the signature insult in combat casualty care. Survival with neurological damage from otherwise lethal blast exposures has become possible with body armor use. We characterized the neuropathologic alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dae4779bcc60d722405e62049465c6f
https://doi.org/10.1089/neu.2010.1540
https://doi.org/10.1089/neu.2010.1540
Publikováno v:
The Journal of Neuroscience. 31:4124-4136
Many new therapeutics for Alzheimer's disease delay the accumulation of amyloid-β (Aβ) in transgenic mice, but evidence for clearance of preexisting plaques is often lacking. Here, we demonstrate that anti-Aβ immunotherapy combined with suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1452e941614b113e339e097e9ce2bedd
https://doi.org/10.1523/jneurosci.5077-10.2011
https://doi.org/10.1523/jneurosci.5077-10.2011
Autor:
Sarah L. Hale, Rogely W. Boyce, Lydia Andrews-Jones, Robert C. Switzer, Bernard S. Jortner, Georg Krinke, Robert H. Garman, Peter B. Little, Mark T. Butt, John T. Boyce, William H. Jordan, Karl F. Jensen
Publikováno v:
Toxicologic Pathology. 39:52-57
This session at the 2010 joint symposium of the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored modern neuropathology methods for assessing the neurotoxicologic potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b8b9ef771308e82cf8e3293db174a4
https://doi.org/10.1177/0192623310394213
https://doi.org/10.1177/0192623310394213
Publikováno v:
Toxicologic Pathology. 39:73-84
Adequate tissue sampling is known to reduce the likelihood that the toxicity of novel biomolecules, chemicals, and drugs might go undetected. Each organ, and often specific structurally and functionally distinct regions within it, must be assessed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b630d5eef40bbcf4091c416daa1ca1e3
https://doi.org/10.1177/0192623310397557
https://doi.org/10.1177/0192623310397557