Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Robert A. Somerville"'
Autor:
Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill, Robert P. Somerville, Nirali N. Shah, David F. Stroncek, Ping Jin
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization of protocols for CAR
Externí odkaz:
https://doaj.org/article/e76402ef6dbc4cf19d5cc3bcdffbfcd6
Autor:
Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101171- (2024)
Chimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products. The first step, T cell selection, removes contamin
Externí odkaz:
https://doaj.org/article/e203f324125d46899b74298138fef026
Autor:
Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin, David F. Stroncek
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vectors in the manufactu
Externí odkaz:
https://doaj.org/article/32a010a258d84ef0bd9faf982f28cee6
Autor:
Lipei Shao, Alejandra Pelayo, Rongye Shi, Jinxia Ma, Hui Liu, Yihua Cai, Michaela Prochazkova, Robert P. Somerville, Sandhya R. Panch, Nirali N. Shah, David F. Stroncek, Ping Jin
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Cytokine release syndrome (CRS) is a strong immune system response that can occur as a result of the reaction of a cellular immunotherapy with malignant cells. While the frequency and management of CRS in CAR T-cell therapy has be
Externí odkaz:
https://doaj.org/article/af570cabca00431987eddf5ab674ba25
Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control
Autor:
Yihua Cai, Michaela Prochazkova, Chunjie Jiang, Hannah W. Song, Jianjian Jin, Larry Moses, Nikolaos Gkitsas, Robert P. Somerville, Steven L. Highfill, Sandhya Panch, David F. Stroncek, Ping Jin
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Chimeric antigen receptor (CAR) or T-cell receptor (TCR) engineered T-cell therapy has recently emerged as a promising adoptive immunotherapy approach for the treatment of hematologic malignancies and solid tumors. Multiparametric
Externí odkaz:
https://doaj.org/article/35545cc4602546ccaa00592203df3230
Autor:
Jinxia Ma, Lipei Shao, Tatyana Fuksenko, Hui Liu, Rongye Shi, Anh Dinh, Steven L. Highfill, Nan Zhang, Sandhya R. Panch, Robert P. Somerville, David F. Stroncek, Ping Jin
Publikováno v:
Cytotherapy. 25:598-604
Autor:
Steven A. Rosenberg, Robert P.T. Somerville, John R. Wunderlich, Mojgan Ahmadzadeh, Parisa Malekzadeh, Drew C. Deniger, Gal Cafri, Winifred Lo, Stephanie L. Goff, Frank J. Lowery, Rami Yossef, Anna Pasetto, Scott Kivitz, Lien T. Ngo, Satyajit Ray, Eric Groh, Abraham Sachs, Jessica S. Crystal, Almin Lalani, Mona El-Gamil, Yong F. Li, Gabriel Ivey, Li Jia, Jared J. Gartner, Todd D. Prickett, Eric Tran, Paul F. Robbins, Maria R. Parkhurst
Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2a4ddb459878d5287a4a96915ed83c
https://doi.org/10.1158/2159-8290.c.6547957.v1
https://doi.org/10.1158/2159-8290.c.6547957.v1
Autor:
Steven A. Rosenberg, Robert P.T. Somerville, John R. Wunderlich, Mojgan Ahmadzadeh, Parisa Malekzadeh, Drew C. Deniger, Gal Cafri, Winifred Lo, Stephanie L. Goff, Frank J. Lowery, Rami Yossef, Anna Pasetto, Scott Kivitz, Lien T. Ngo, Satyajit Ray, Eric Groh, Abraham Sachs, Jessica S. Crystal, Almin Lalani, Mona El-Gamil, Yong F. Li, Gabriel Ivey, Li Jia, Jared J. Gartner, Todd D. Prickett, Eric Tran, Paul F. Robbins, Maria R. Parkhurst
Supplementary Figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e0fb582e053a61b07254758048727c
https://doi.org/10.1158/2159-8290.22535827.v1
https://doi.org/10.1158/2159-8290.22535827.v1
Autor:
Steven A. Rosenberg, Robert P.T. Somerville, John R. Wunderlich, Mojgan Ahmadzadeh, Parisa Malekzadeh, Drew C. Deniger, Gal Cafri, Winifred Lo, Stephanie L. Goff, Frank J. Lowery, Rami Yossef, Anna Pasetto, Scott Kivitz, Lien T. Ngo, Satyajit Ray, Eric Groh, Abraham Sachs, Jessica S. Crystal, Almin Lalani, Mona El-Gamil, Yong F. Li, Gabriel Ivey, Li Jia, Jared J. Gartner, Todd D. Prickett, Eric Tran, Paul F. Robbins, Maria R. Parkhurst
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ef3a4e59eeeb735a86058ec5edd253
https://doi.org/10.1158/2159-8290.22535836.v1
https://doi.org/10.1158/2159-8290.22535836.v1
Publikováno v:
Int Rev Immunol
Engineered T cell therapies such as CAR-T cells and TCR-T cells have generated impressive patient responses in previously incurable diseases. In the past few years there have been a number of technical innovations that enable robust clinical manufact