Zobrazeno 1 - 10
of 479
pro vyhledávání: '"Robert A. Shearer"'
Autor:
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.
Externí odkaz:
https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d
Autor:
Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-17 (2019)
Abstract Background The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates PI3K signalling. Antibody-mediated inhibition of this ERBB2/ERBB3/PI3K
Externí odkaz:
https://doaj.org/article/63c93a219e074dd1a11996f46df83abd
Autor:
Seher Balaban, Lisa S. Lee, Bianca Varney, Atqiya Aishah, Quanqing Gao, Robert F. Shearer, Darren N. Saunders, Thomas Grewal, Andrew J. Hoy
Publikováno v:
Molecular Oncology, Vol 12, Iss 9, Pp 1623-1638 (2018)
Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains
Externí odkaz:
https://doaj.org/article/5d724f44ca4044cc80431de3ffd48d82
Autor:
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancre
Externí odkaz:
https://doaj.org/article/1dd7417190fc4a1586f84ed7e4b76935
Autor:
Andrew J. Hoy, Lisa M. Butler, Lisa G. Horvath, Jeff Holst, Darren N. Saunders, Meghna S. Kakani, Nikki L. Raftopulos, Rae-Anne Hardie, Robert F. Shearer, Shilpa R. Nagarajan, Lisa S. Lee, Frank Liu-Fu, Bianca Varney, Atqiya Aishah, Hui-Ming Lin, Mark Schreuder, Margaret M. Centenera, Elham Hosseini-Beheshti, Alison Y. Zhang, Zeyad D. Nassar, Seher Balaban
S1: Pretreatment of PC-3 and C4-2B cells with a FA Mix alters the response to palmitate lipotoxicity and serum-starvation. S2: Dose response assessment of palmitate supplementation on cell viability. S3: Pretreatment with the DGAT1 inhibitor AZD3988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73170f582eb49a3293a5afcb6456b8e5
https://doi.org/10.1158/1541-7786.22512309.v1
https://doi.org/10.1158/1541-7786.22512309.v1
Autor:
Andrew J. Hoy, Lisa M. Butler, Lisa G. Horvath, Jeff Holst, Darren N. Saunders, Meghna S. Kakani, Nikki L. Raftopulos, Rae-Anne Hardie, Robert F. Shearer, Shilpa R. Nagarajan, Lisa S. Lee, Frank Liu-Fu, Bianca Varney, Atqiya Aishah, Hui-Ming Lin, Mark Schreuder, Margaret M. Centenera, Elham Hosseini-Beheshti, Alison Y. Zhang, Zeyad D. Nassar, Seher Balaban
Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased de novo synthesis of fatty acids (FA); however, little is known about how extracellular FAs, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::044e3d871558d96a3327f380e00756f5
https://doi.org/10.1158/1541-7786.c.6540204.v1
https://doi.org/10.1158/1541-7786.c.6540204.v1
Autor:
Alexander Swarbrick, D. Neil Watkins, Robert L. Sutherland, Daniel Christ, Elizabeth A. Musgrove, Gregory E. Hannigan, Duc Vu, Luciano G. Martelotto, Brian Rabinovich, Min Ru Qiu, Christopher J. Ormandy, Akira Nguyen, Andrea McFarland, Catriona M. McNeil, Caroline L. Cooper, Duncan McLeod, Peter Schofield, Radhika Nair, Ewan K.A. Millar, Robert F. Shearer, Dorothy A. Machalek, Sandra A. O'Toole
Supplementary Methods, Tables 1-3, Figures 1-4 from Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a865878f73e7afd97e6296fca838e86
https://doi.org/10.1158/0008-5472.22394718.v1
https://doi.org/10.1158/0008-5472.22394718.v1
Autor:
Jodi A Lee, Justin J Yerbury, Natalie Farrawell, Robert F Shearer, Patrick Constantinescu, Danny M Hatters, Wayne A Schroder, Andreas Suhrbier, Mark R Wilson, Darren N Saunders, Marie Ranson
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130136 (2015)
SerpinB2 (PAI-2), a member of the clade B family of serine protease inhibitors, is one of the most upregulated proteins following cellular stress. Originally described as an inhibitor of urokinase plasminogen activator, its predominant cytoplasmic lo
Externí odkaz:
https://doaj.org/article/8de4b07eb2c94e1780f91faa6c9be742
Autor:
Woolley, Drew
Publikováno v:
FierceRetail. 5/4/2015, p1-1. 1p.
Autor:
Zeyad D. Nassar, Meghna S. Kakani, Andrew J. Hoy, Hui-Ming Lin, Jeff Holst, Lisa S. Lee, Robert F. Shearer, Lisa G. Horvath, Darren N. Saunders, Elham Hosseini-Beheshti, Margaret M. Centenera, Lisa M. Butler, Seher Balaban, Shilpa R. Nagarajan, Mark Schreuder, Nikki L. Raftopulos, Frank Liu-Fu, Atqiya Aishah, Bianca Varney, Alison Yan Zhang, Rae-Anne Hardie
Publikováno v:
Molecular Cancer Research. 17:949-962
Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased de novo synthesis of fatty acids (FA); however, little is known about how extracellular FAs, such