Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert A. Scism"'
Autor:
Gregory R.J. Thatcher, Judy L. Bolton, Marton I. Siklos, Rui Xiong, Bradley T. Michalsen, Robert A. Scism, Emily N. Thayer, Yijin Wang, Shuai Wang, Sujeewa C. Piyankarage, Jaewoo Choi, R. Esala P. Chandrasena, Hitisha Patel, L.P. Madhubhani P. Hemachandra
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9bdf2f7a62eabcf8004690574fdef4
https://doi.org/10.1158/1940-6207.c.6544512
https://doi.org/10.1158/1940-6207.c.6544512
Autor:
Judy L. Bolton, Gregory R.J. Thatcher, Guido F. Pauli, Birgit M. Dietz, Robert A. Scism, David C. Lankin, Matthew Main, Shao-Nong Chen, P. Esala, R. Chandrasena, P. Madhubhani, L.P. Hemachandra
Long-term exposure to estrogens including those in traditional hormone replacement therapy (HRT) increases the risk of developing hormone-dependent cancers. As a result, women are turning to over-the-counter (OTC) botanical dietary supplements, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2af6c6cf4ef98cad8053033ab957eaf
https://doi.org/10.1158/1940-6207.c.6544635
https://doi.org/10.1158/1940-6207.c.6544635
Autor:
Gregory R.J. Thatcher, Judy L. Bolton, Marton I. Siklos, Rui Xiong, Bradley T. Michalsen, Robert A. Scism, Emily N. Thayer, Yijin Wang, Shuai Wang, Sujeewa C. Piyankarage, Jaewoo Choi, R. Esala P. Chandrasena, Hitisha Patel, L.P. Madhubhani P. Hemachandra
PDF file - 391K, Supplementary Figure S1: Recombinant COMT (10 microg/mL) was incubated with S-(5'-adenosyl)-L-methionine (500 nM) and raloxifene, DMA, or bazadoxifene (1 microM ) at 37 degrees C for 5 minutes prior to the addition of 6,7-dihydroxyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdad968c2164fd8129f4d51c4467a09
https://doi.org/10.1158/1940-6207.22524975.v1
https://doi.org/10.1158/1940-6207.22524975.v1
Autor:
Judy L. Bolton, Gregory R.J. Thatcher, Guido F. Pauli, Birgit M. Dietz, Robert A. Scism, David C. Lankin, Matthew Main, Shao-Nong Chen, P. Esala, R. Chandrasena, P. Madhubhani, L.P. Hemachandra
PDf file - 294K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a1ef25ae0847792275d53d2dafcd12
https://doi.org/10.1158/1940-6207.22525224
https://doi.org/10.1158/1940-6207.22525224
Autor:
Rui Xiong, Marton I. Siklos, Jaewoo Choi, Bradley T. Michalsen, Robert A. Scism, R. Esala P. Chandrasena, Emily N. Thayer, Sujeewa C. Piyankarage, Yijin Wang, Shuai Wang, L. P. Madhubhani P. Hemachandra, Judy L. Bolton, Hitisha K. Patel, Gregory R. J. Thatcher
Publikováno v:
Cancer Prevention Research. 7:505-515
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabol
Autor:
R Chandrasena, Birgit M. Dietz, Robert A. Scism, Shao-Nong Chen, Gregory R. J. Thatcher, Matthew Main, P Esala, P Madhubhani, Guido F. Pauli, Judy L. Bolton, Lpmp Hemachandra, David C. Lankin
Publikováno v:
Cancer Prevention Research. 5:73-81
Long-term exposure to estrogens including those in traditional hormone replacement therapy (HRT) increases the risk of developing hormone-dependent cancers. As a result, women are turning to over-the-counter (OTC) botanical dietary supplements, such
Autor:
Brian O. Bachmann, Robert A. Scism
Publikováno v:
ChemBioChem. 11:67-70
Publikováno v:
Organic Letters. 9:4179-4182
An Escherichia coli strain overexpressing a mutant variant of a phosphoribosyl transferase was developed as a catalyst for the efficient preparation of a range of purine nucleotide analogues. This system offers an efficient and rapid method for nucle
Autor:
Vaishali Sinha, Isaac T. Schiefer, Gregory R. J. Thatcher, Mauro Fa, Robert A. Scism, Michael Brunsteiner, R. Esala P. Chandrasena, Vladislav A. Litosh, Subhasish Tapadar, Ehsan Tavassoli, Gihani T. Wijewickrama, Marton I. Siklos, Ottavio Arancio, Pavel A. Petukhov
Publikováno v:
Journal of medicinal chemistry. 56(15)
Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological event in a wide range of illnesses and in neurodegenerative states, including Alzheimer's disease (AD). E-64 is an epoxid
To address the synthesis of increasingly structurally diverse small-molecule drugs, methods for the generation of efficient and selective biological catalysts are becoming increasingly important. ‘Directed evolution’ is an umbrella term referring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0727e874adc631fe9ca0c79f24fa2427
https://europepmc.org/articles/PMC3155183/
https://europepmc.org/articles/PMC3155183/