Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Robert A. Rollins"'
1
Akademický článek
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib
Autor: Xia Ding, Zhou Zhu, John Lapek, Elizabeth A. McMillan, Alexander Zhang, Chi-Yeh Chung, Sara Dubbury, Jennifer Lapira, Sarah Firdaus, Xiaolin Kang, Jingjin Gao, Jon Oyer, John Chionis, Robert A. Rollins, Lianjie Li, Sherry Niessen, Shubha Bagrodia, Lianglin Zhang, Todd VanArsdale
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors
Externí odkaz: https://doaj.org/article/b28d91d2e3b2470492e4d111d6c1fbcd
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2
Akademický článek
Unprecedented genetic variability of PFam54 paralogs among Eurasian Lyme borreliosis‐causing spirochetes
Autor: Janna Wülbern, Laura Windorfer, Kozue Sato, Minoru Nakao, Sabrina Hepner, Gabriele Margos, Volker Fingerle, Hiroki Kawabata, Noémie S. Becker, Peter Kraiczy, Robert E. Rollins
Publikováno v: Ecology and Evolution, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Lyme borreliosis (LB) is the most common vector‐borne disease in the Northern Hemisphere caused by spirochetes belonging to the Borrelia burgdorferi sensu lato (Bbsl) complex. Borrelia spirochetes circulate in obligatory transmission cycle
Externí odkaz: https://doaj.org/article/4392d14ecc584af1b608c994641d309d
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3
Akademický článek
A high fidelity approach to assembling the complex Borrelia genome
Autor: Sabrina Hepner, Konstantin Kuleshov, Ave Tooming-Kunderud, Nikolas Alig, Alexander Gofton, Sherwood Casjens, Robert E. Rollins, Alexandra Dangel, Evangelos Mourkas, Samuel K. Sheppard, Andreas Wieser, Johannes Hübner, Andreas Sing, Volker Fingerle, Gabriele Margos
Publikováno v: BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Bacteria of the Borrelia burgdorferi sensu lato (s.l.) complex can cause Lyme borreliosis. Different B. burgdorferi s.l. genospecies vary in their host and vector associations and human pathogenicity but the genetic basis for thes
Externí odkaz: https://doaj.org/article/537dae20a7534ae0a058a30caaee0e78
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4
Akademický článek
High conservation combined with high plasticity: genomics and evolution of Borrelia bavariensis
Autor: Noémie S. Becker, Robert E. Rollins, Kateryna Nosenko, Alexander Paulus, Samantha Martin, Stefan Krebs, Ai Takano, Kozue Sato, Sergey Y. Kovalev, Hiroki Kawabata, Volker Fingerle, Gabriele Margos
Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Background Borrelia bavariensis is one of the agents of Lyme Borreliosis (or Lyme disease) in Eurasia. The genome of the Borrelia burgdorferi sensu lato species complex, that includes B. bavariensis, is known to be very complex and fragmente
Externí odkaz: https://doaj.org/article/de2310a799754a0b8ee9937ee3fb14c1
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5
Out of Asia? Expansion of Eurasian Lyme borreliosis causing genospecies display unique evolutionary trajectories
Autor: Robert E. Rollins, Kozue Sato, Minoru Nakao, Mohammed T. Tawfeeq, Fernanda Herrera‐Mesías, Ricardo J. Pereira, Sergey Kovalev, Gabriele Margos, Volker Fingerle, Hiroki Kawabata, Noémie S. Becker
Publikováno v: Molecular Ecology. 32:786-799
Vector-borne pathogens exist in obligate transmission cycles between vector and reservoir host species. Host and vector shifts can lead to geographic expansion of infectious agents and the emergence of new diseases in susceptible individuals. Three b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d315e75d95cf8ff8cad1dd0e7f9258cd
https://doi.org/10.1111/mec.16805
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6
GermanIxodes inopinatussamples may not actually represent this tick species
Autor: Robert E. Rollins, Gabriele Margos, Andreas Brachmann, Stefan Krebs, Alexia Mouchet, Niels J. Dingemanse, AbdElkarim Laatamna, Nassiba Reghaissia, Volker Fingerle, Dirk Metzler, Noémie S. Becker, Lidia Chitimia-Dobler
Ticks are important vectors of human and animal pathogens, but many questions remain unanswered regarding their taxonomy. Molecular sequencing methods have allowed research to start understanding the evolutionary history of even closely related tick
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d59f642a7a8265c1e598dfb9005d8e8
https://doi.org/10.1101/2023.02.14.528458
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7
Utilizing Two Borrelia bavariensis Isolates Naturally Lacking the PFam54 Gene Array To Elucidate the Roles of PFam54-Encoded Proteins
Autor: Robert E. Rollins, Janna Wülbern, Florian Röttgerding, Tristan A. Nowak, Sabrina Hepner, Volker Fingerle, Gabriele Margos, Yi-Pin Lin, Peter Kraiczy, Noémie S. Becker
Publikováno v: Appl Environ Microbiol
Lyme borreliosis is the most common vector-borne disease in the Northern Hemisphere, caused by spirochetes belonging to the Borrelia burgdorferi sensu lato species complex, which are transmitted by ixodid ticks. B. burgdorferi sensu lato species prod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5383c0f404aa15e3aa7e22821b4b23b
https://doi.org/10.1128/aem.01555-21
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8
The Population Structure of Borrelia lusitaniae Is Reflected by a Population Division of Its Ixodes Vector
Autor: Michal Chvostáč, Volker Fingerle, Robert E. Rollins, Ana Cláudia Norte, Isabel Lopes de Carvalho, Tom Woudenberg, Maria Sofia Núncio, Yuliya M. Didyk, Santiago Castillo-Ramírez, Gabriele Margos, Pierre H. Boyer, Markéta Derdáková, Mohand O Brahami
Publikováno v: Microorganisms
Volume 9
Issue 5
Microorganisms, Vol 9, Iss 933, p 933 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Popu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702fe847157384a108633289403e5967
https://hdl.handle.net/10400.18/7885
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9
Repeatable differences in exploratory behaviour predict tick infestation probability in wild great tits
Autor: Alexia Mouchet, Gabriele Margos, Niels Jeroen Dingemanse, Robert E. Rollins, Noémie S. Becker, Volker Fingerle, Lidia Chitimia-Dobler
Publikováno v: Behavioral Ecology and Sociobiology. 75
Abstract Ecological factors and individual-specific traits affect parasite infestation in wild animals. Ixodid ticks are important ectoparasites of various vertebrate hosts, which include passerine bird species such as the great tit (Parus major). We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35aef5dde960ed92bb3600b5b1fd47b8
https://doi.org/10.1007/s00265-021-02972-y
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10
The complex role of EZH2 in the tumor microenvironment: opportunities and challenges for immunotherapy combinations
Autor: Shikhar Sharma, Jing Qiu, Thomas A Paul, Robert A. Rollins
Publikováno v: Future medicinal chemistry. 12(15)
Immune dysfunction in the tumor microenvironment occurs through epigenetic changes in both tumor cells and immune cells that alter transcriptional programs driving cell fate and cell function. Oncogenic activation of the histone methyltransferase EZH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3829dfe526f204824ca08572bae838
https://pubmed.ncbi.nlm.nih.gov/32723083
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